Gels, Год журнала: 2024, Номер 10(12), С. 762 - 762

Опубликована: Ноя. 23, 2024

Exosome-integrated hydrogels represent a promising frontier in bone tissue engineering, leveraging the unique biological properties of exosomes to enhance regenerative capabilities hydrogels. Exosomes, as naturally occurring extracellular vesicles, carry diverse array bioactive molecules that play critical roles intercellular communication and regeneration. When combined with hydrogels, these can be spatiotemporally delivered target sites, offering controlled sustained release therapeutic agents. This review aims provide comprehensive overview recent advancements development, application exosome-integrated for highlighting their potential overcome current challenges Furthermore, explores mechanistic pathways by which embedded within facilitate repair, encompassing regulation inflammatory pathways, enhancement angiogenic processes, induction osteogenic differentiation. Finally, addresses existing challenges, such scalability, reproducibility, regulatory considerations, while also suggesting future directions research this rapidly evolving field. Thus, we hope contributes advancing development next-generation biomaterials synergistically integrate exosome hydrogel technologies, thereby enhancing efficacy

Язык: Английский