ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Uniform,
mesoporous
copper(II)
oxide
nanospindles
(CuO
NSs)
were
synthesized
via
a
method
based
on
templated
hydrothermal
oxidation
of
copper
in
the
presence
monodisperse
poly(glycerol
dimethacrylate-co-methacrylic
acid)
nanoparticles
(poly(GDMA-co-MAA)
NPs).
Subsequent
decoration
CuO
NSs
with
CaO2
nanoshell
(CuO@CaO2
yielded
nanozyme
capable
Cu(I)/Cu(II)
redox
cycling.
Activation
cycle
by
exogenously
generated
H2O2
from
significantly
enhanced
glutathione
(GSH)
depletion.
CuO@CaO2
exhibited
2-fold
higher
GSH
depletion
rate
compared
to
pristine
NSs.
The
generation
oxygen
due
catalase
(CAT)-like
decomposition
resulted
self-propelled
diffusion
behavior,
characteristic
fueled
nanomotor.
These
nanostructures
both
peroxidase
(POD)-like
and
CAT-like
activities
self-production
aqueous
media
chemical
reaction
between
water.
Usage
self-supplied
POD-like
activity
amplified
toxic
hydroxyl
(•OH)
radicals,
enhancing
chemodynamic
effect
within
tumor
microenvironment
(TME).
provided
source
O2
alleviate
hypoxic
conditions
TME.
Under
near-infrared
laser
irradiation,
photothermal
conversion
properties,
temperature
elevation
25
°C.
combined
led
more
effective
production
•OH
radicals
cell
culture
medium.
function
was
further
an
elevated
temperature.
To
assess
therapeutic
potential,
loaded
photosensitizer,
chlorine
e6
(Ce6),
evaluated
against
T98G
glioblastoma
cells.
synergistic
combination
photodynamic,
photohermal,
modalities
using
CuO@CaO2@Ce6
death
than
90%
under
vitro
conditions.
Biosensors,
Год журнала:
2024,
Номер
14(12), С. 563 - 563
Опубликована: Ноя. 21, 2024
Choline
is
an
important
molecule
in
monitoring
food
safety
and
infant
nutrition.
Here,
we
report
Ce
nanogels
synthesized
by
atom
transfer
radical
polymerization
(ATRP)
employing
Ce-coordinated
acryloyl-lysine
polymer
brushes
(Ce@SiO2
NGs)
as
highly
efficient
cascade
nanozymes
for
colorimetric
detection
of
choline.
The
Ce@SiO2
NGs
demonstrated
remarkable
peroxidase-like
activity
with
a
porous
exterior,
which
are
essential
to
entrap
choline
oxidase
(COx)
yield
COx@Ce@SiO2
construct
reaction
system
detect
Immobilized
COx
catalyzed
the
oxidation
samples
produce
H2O2,
subsequently
induced
chromogenic
substrate
3,3′,5,5′-tetramethylbenzidine
(TMB)
blue
color
signals.
This
method
enabled
selective
sensitive
target
satisfactory
linear
range
4–400
μM,
sufficient
analyze
foodborne
practical
utility
NG-based
assay
was
successfully
validated
determine
spiked
commercially
available
milk
formula
high
accuracy
precision
values.
approach
provides
simple
affordable
has
potential
lead
more
developments
ATRP-based
diverse
biosensing
applications.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Uniform,
mesoporous
copper(II)
oxide
nanospindles
(CuO
NSs)
were
synthesized
via
a
method
based
on
templated
hydrothermal
oxidation
of
copper
in
the
presence
monodisperse
poly(glycerol
dimethacrylate-co-methacrylic
acid)
nanoparticles
(poly(GDMA-co-MAA)
NPs).
Subsequent
decoration
CuO
NSs
with
CaO2
nanoshell
(CuO@CaO2
yielded
nanozyme
capable
Cu(I)/Cu(II)
redox
cycling.
Activation
cycle
by
exogenously
generated
H2O2
from
significantly
enhanced
glutathione
(GSH)
depletion.
CuO@CaO2
exhibited
2-fold
higher
GSH
depletion
rate
compared
to
pristine
NSs.
The
generation
oxygen
due
catalase
(CAT)-like
decomposition
resulted
self-propelled
diffusion
behavior,
characteristic
fueled
nanomotor.
These
nanostructures
both
peroxidase
(POD)-like
and
CAT-like
activities
self-production
aqueous
media
chemical
reaction
between
water.
Usage
self-supplied
POD-like
activity
amplified
toxic
hydroxyl
(•OH)
radicals,
enhancing
chemodynamic
effect
within
tumor
microenvironment
(TME).
provided
source
O2
alleviate
hypoxic
conditions
TME.
Under
near-infrared
laser
irradiation,
photothermal
conversion
properties,
temperature
elevation
25
°C.
combined
led
more
effective
production
•OH
radicals
cell
culture
medium.
function
was
further
an
elevated
temperature.
To
assess
therapeutic
potential,
loaded
photosensitizer,
chlorine
e6
(Ce6),
evaluated
against
T98G
glioblastoma
cells.
synergistic
combination
photodynamic,
photohermal,
modalities
using
CuO@CaO2@Ce6
death
than
90%
under
vitro
conditions.
