Ultrasound-enhanced dual-responsive bismuth nanocatalysts for alleviating tumor hypoxia and promoting breast cancer sonodynamic-immunotherapy
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160292 - 160292
Опубликована: Фев. 1, 2025
Язык: Английский
Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Hydrogen
therapy
has
shown
new
potential
in
cancer
treatment,
particularly
high-pressure
and
hypoxic
areas,
where
it
demonstrates
the
ability
to
alter
tumor
microenvironment
regulate
metabolism.
disrupts
mitochondrial
function
of
cells,
interferes
with
their
energy
metabolism,
ultimately
leads
depletion
apoptosis.
In
this
study,
a
sonocatalyst
(BPM),
is
designed
generate
hydrogen
oxygen
situ
within
tumors,
further
enhancing
therapeutic
efficacy.
The
mesocrystalline
structure
BPM,
composed
bismuth
fluoride,
polyoxometalates,
molybdenum
carbide,
significantly
improves
charge
separation
electron
transfer
efficiency
under
ultrasound
irradiation,
resulting
an
efficient
water-splitting
reaction.
By
simultaneously
generating
depleting
glutathione,
BPM
effectively
triggers
oxidative
stress
alleviates
hypoxia,
thereby
disrupting
inhibiting
metabolism
cells.
Additionally,
enhances
antitumor
immune
responses
by
promoting
dendritic
cell
maturation,
activating
T
lymphocytes,
polarizing
macrophages
toward
M1
phenotype,
reversing
immunosuppressive
state
microenvironment.
results
indicate
that
holds
for
gas-immunotherapy
combination
treatments,
offering
multifunctional
strategy
improve
outcomes.
Язык: Английский
Non-central symmetric 2D bismuth‐based perovskites for piezoelectric-enhanced sonodynamic immunotherapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
687, С. 386 - 401
Опубликована: Фев. 13, 2025
Язык: Английский
Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
687, С. 801 - 816
Опубликована: Фев. 17, 2025
Язык: Английский
Current advances in nanozyme-based nanodynamic therapies for cancer
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy
Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Nanozymes,
which
are
nanomaterials
that
replicate
the
catalytic
activities
of
natural
enzymes
in
biological
systems,
have
recently
demonstrated
considerable
potential
improving
cancer
immunotherapy
by
altering
tumor
microenvironment.
Nanozyme-driven
immune
responses
represent
an
innovative
therapeutic
modality
with
high
effectiveness
and
minimal
side
effects.
These
nanozymes
activate
system
to
specifically
recognize
destroy
cells.
Combined
immunotherapeutic
agents,
can
amplify
anti-cancer
integrating
remodeling
immunogenic
cell
death
(ICD).
This
review
offers
a
thorough
discussion
about
various
involved
immunity,
including
those
mimicking
catalase
(CAT),
superoxide
dismutase
(SOD),
peroxidase
(POD),
oxidase
(OXD).
It
also
discusses
challenges
future
directions
for
translating
nanozyme
platforms
into
clinical
applications,
enhancing
susceptibility
cells
immunotherapy.
Nanozyme-based
strategies
substantial
oncology,
offering
new
effective
options
management.
Язык: Английский
A “CPApoptosis” nano-actuator switches immune-off solid tumors to immune-on for fueling T-cell- based immunotherapy
Theranostics,
Год журнала:
2025,
Номер
15(9), С. 3797 - 3820
Опубликована: Март 3, 2025
Background:
Most
anticancer
agents
induce
tumor
apoptosis,
but
they
often
lack
immunogenicity
and
display
limited
success
when
combined
with
mainstream
immunotherapies,
thus
killing
cancer
cells
through
multiple
cell
death
modalities
as
well
switching
immune-off
tumors
to
immune-on
is
a
strategy
great
promise.
To
this
end,
we
developed
CPApoptosis
(cuproptosis,
pyroptosis,
apoptosis)
nano-actuator
for
immunologically
cold
solid
tumors.
Methods:
In
study,
elesclomol
(ES),
mitochondrial
targeting
copper
transporter,
was
encapsulated
within
bacterial
outer
membrane
vesicles
(OMVs).
These
OMVs
were
then
surface-modified
via
metal-phenolic
self-assembly
using
Cu2+
tannic
acid
(TA).
Results:
The
ES
released
from
the
in
pH-dependent
manner.
OMV
activated
non-canonical
pyroptotic
pathway,
leading
rupture.
on
one
hand
transported
mitochondria
cuproptosis
facilitated
by
ES,
other
hand,
reduced
into
Cu+
TA,
which
catalyzed
ROS
production
oxidative
apoptosis.
Simultaneously,
TA
degraded
glutathione
(GSH),
sensitizing
cuproptosis.
multifactorial
mechanisms
led
release
of
immunogenic
factors
lysed
cells,
stimulating
dendritic
maturation
recruiting
cytotoxic
T
cells.
This
immune
response
further
amplified
αPD-L1
antibody
treatment.
Conclusion:
represents
promising
approach
enhance
current
therapies,
inducing
both
robust
response,
potential
long-lasting
protective
effects.
Язык: Английский
The molecular mechanisms, roles, and potential applications of PANoptosis in cancer treatment
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 29, 2025
PANoptosis,
a
newly
identified
form
of
programmed
cell
death
regulated
by
the
panoptosome
complex,
exhibits
key
characteristics
apoptosis,
pyroptosis
and
necroptosis.
It
exerts
substantial
influence
on
initiation
progression
spectrum
diseases,
particularly
in
cancer,
where
its
impact
is
increasingly
being
recognized.
PANoptosis
closely
related
to
tumorigenesis,
carcinogenesis,
metastasis,
chemotherapy
resistance,
as
well
prediction
therapeutic
responses
prognosis
cancer
patients.
In
this
review,
we
first
review
discovery
systematically
analyze
composition
panoptosome.
Subsequently,
examine
role
various
types
encompassing
function
within
tumor
microenvironment,
drug
predictive
prognosis.
Ultimately,
delve
into
strategies
for
targeting
therapy,
including
molecules
pathway,
such
ZBP1,
RIPK1,
RIPK3,
Caspases
other
novel
like
nanoinducers
viral
vectors.
This
aims
provide
references
assistance
research
application
treatment.
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский