Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Июнь 3, 2025

Cancer treatment has been revolutionized by immunotherapy and nanomedicine, offering innovative strategies to overcome the tumor microenvironment (TME) complexities. However, challenges such as therapeutic resistance, off-target effects, immune suppression necessitate advanced delivery systems combination approaches. Recent advancements in nanoparticle-based therapies, biomimetic platforms, personalized provide promising solutions enhance efficacy while minimizing systemic toxicity. This review explores recent nanoparticle-mediated developments, highlighting optimize drug delivery, remodel TME, improve patient-specific outcomes. A comprehensive of literature focused on stimuli-responsive systems, nanoplatforms, The effectiveness therapies integrating physical immunological was also analyzed. Nanoparticle-mediated enables precise targeting controlled release, significantly improving Biomimetic nanoplatforms modulation bioavailability, immunotherapy, guided predictive biomarkers, tailors individual patients. Advanced nanomedicine strategies, including TME remodeling, targeted genome editing, immunotherapies, offer avenues for overcoming limitations conventional cancer treatments. Future research should nanoformulations, integrate multi-modal refine biomarker-driven personalization clinical

Язык: Английский