Bioactive Materials, Год журнала: 2025, Номер 51, С. 211 - 230
Опубликована: Май 13, 2025
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140797 - 140797
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142134 - 142134
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Biomaterials, Год журнала: 2024, Номер 315, С. 122964 - 122964
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1084 - 1084
Опубликована: Янв. 27, 2025
In this work, the spectroscopy of epigallocatechin-3-gallate (EGCG) and EGCG bonded to 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DPPG) lipid is studied both experimentally by combining high-resolution vacuum ultraviolet (VUV) photo-absorption measurements in 4.0–9.0 eV energy range theoretical calculations using density functional theory (DFT) methodology. There a good agreement between experimental data, inclusion solvent implicitly explicitly further improves agreement. For all measured absorption bands observed VUV spectra water, assignments calculated electronic transitions are provided. The reveal that spectrum DPPG-EGCG has an intense peak around 150 nm, which accordance with it assigned electron transfer transition from resorcinol–pyrogallol groups different smaller molecule. Finally, increase absorbance can be associated interaction molecules.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization reactive oxygen species (ROS), suppression inflammation, and induction angiogenesis. This study describes development a multifunctional hyaluronic acid (HA)-based microgel system capable serving as either an injectable wet or dry microspheres (MSs). After initially engineering Fe2+/tea polyphenol (TP) metal-polyphenol network (MPN)-functionalized HAMA MS, these particles were found to suppress inflammation facilitate ROS scavenging. A deferoxamine (DFO)-loaded zinc-based metal-organic framework (ZIF-8@DFO) was then coated using phenylboronic (PBA)-functionalized ε-polylysine (PPL) produce PPZD nanoparticles with antibacterial pro-angiogenic properties. The dynamic loading into MPN-functionalized MS (MMS) via boron ester bonds yielded pH/ROS-responsive (MMS@PPZD). PPL coating endowed prepared materials antimicrobial properties while mitigating cytotoxic effects resulting from rapid release Zn2+ DFO in acidic micro-environments. showed superior biocompatibility phased intervention activities aligned various stages wound healing process vitro vivo. Specifically, under conditions, sequentially released TP, PL, Zn2+, DFO, enabling effective scavenging, suppressing exhibiting activity, inducing Overall, this environmentally-responsive, multifunctional, versatile offers significant promise for management.
Язык: Английский
Процитировано
0
Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)
Опубликована: Март 1, 2025
Abstract Nowadays, diseases have a high rate of incidence and mortality worldwide. On the other side, drawbacks conventional modalities in suppression encountered serious problematic issues for health human beings. For instance, although various approaches been applied treatment cancer, it has an ever‐increasing throughout globe. Thus, there is fundamental requirement development breakthrough technologies inhibition diseases. Hyaluronic acid (HA) one most practical biopolymers HA lots potential physicochemical (like rheological, structural, molecular weight, ionization, etc.) biomedical properties (bioavailability, biocompatibility, CD44 targeting signaling pathways, components biological organs, mucoadhesion, immunomodulation, etc.), which made candidate tools pharmaceutical sciences. The ease surface modification (carboxylation, amidation, hydroxylation, esterification), bioavailability synthesis routes, administration routes are considered as merits HA‐based vehicles. These mucopolysaccharide materials considerably developed use drug delivery systems (DDSs), cancer therapy, wound healing, antiaging, tissue engineering. This review summarizes advantages DDS scaffolds
Язык: Английский
Процитировано
0
ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1626 - 1645
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер 147(19), С. 16362 - 16378
Опубликована: Апрель 30, 2025
Chronic diabetic wounds are prone to severe skin necrosis and bacterial infections, with elevated reactive oxygen species (ROS) persistent inflammation further hindering the healing process. Developing smart dressings multifunctional therapeutic capabilities simultaneously combat reduce oxidative stress, alleviate inflammation, promote tissue regeneration remains a significant challenge. Here, we introduce self-adaptive yet hydrogel (Exo-Gel) designed accelerate methicillin-resistant Staphylococcus aureus (MRSA)-infected wound repair. Exo-Gel utilizes choline phosphate (CP) groups both anchor stem cell-derived exosomes (Exo) via electrostatic interactions disrupt membranes, providing inherent bacteriostatic effects. Additionally, ROS-responsive thioketal (TK) linkers enable release of based on local ROS levels while also scavenging excess ROS. This synergistic system facilitates by modulating reducing promoting M2 macrophage polarization, enhancing cell proliferation, myofibroblast migration, angiogenesis, collagen deposition regeneration. In Sprague-Dawley rats MRSA-infected full-thickness wounds, achieved remarkable activity accelerated healing. offers cost-effective, multifunctional, strategy for managing chronic requiring no external components or operations, making it highly practical translatable clinical applications.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 143923 - 143923
Опубликована: Май 3, 2025
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 51, С. 211 - 230
Опубликована: Май 13, 2025
Язык: Английский
Процитировано
0