Viscoelastic Mechanics: From Pathology and Cell Fate to Tissue Regeneration Biomaterial Development

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Viscoelasticity is the mechanical feature of living tissues and cellular extracellular matrix (ECM) has been recognized as an essential biophysical cue in cell function fate regulation, tissue development homeostasis maintenance, disease progression. These findings provide new insights for biomaterials with comparable viscoelastic properties native ECMs matrix, displaying promising applications regeneration medicine. In this review, relationship between viscoelasticity functions (e.g., regeneration) physiological conditions progression aging, degenerative, fibrosis, tumor) pathological will be especially highlighted to figure out potential therapeutic target treatment inspiration related biomaterial development. Furthermore, understanding response ECM mechanism behind it are comprehensively summarized a pathophysiological basis design. The advances on defect repair also reviewed, suggesting significance matchable microenvironment regeneration. Although challenging, tunable that match show great promise. They could promote regeneration, treat degenerative diseases, support organoids artificial organs.

Язык: Английский

Vascularization of Organoid Microenvironments: Perfusable Networks for Organoid Growth and Maturation

Current Opinion in Biomedical Engineering, Год журнала: 2025, Номер unknown, С. 100586 - 100586

Опубликована: Март 1, 2025

Язык: Английский