Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury DOI
Man Li, Lijuan Yang,

Yibo An

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Acute kidney injury (AKI) is a life-threatening condition characterized by rapid decline in the renal function, primarily caused oxidative stress, inflammation, and ferroptosis. Herein, we present selenium-doped carbon dots (Zt-SeCDs) that integrate antioxidant activity with controlled release of Zileuton, 5-lipoxygenase (ALOX5) inhibitor, under high reactive oxygen species (ROS) conditions. This nanoplatform can efficiently deliver leveraging its inherent properties to achieve targeted prevention treatment AKI. In vitro studies have confirmed Zt-SeCDs eliminate excessive ROS, prevent ferroptotic cell death, modulate inflammatory responses reducing expression key pro-inflammatory cytokines. Additionally, regulate ferroptosis through suppression ALOX5 upregulation glutathione peroxidase 4 (GPX4) expression. The significantly improves promotes regeneration damaged tissue, alleviates processes, death. Moreover, monitoring serum indicators observing pathological changes further potential preventing Notably, activate AMPK/FoxO1 signaling pathway, enhancing endogenous defenses protect tissue from damage. promising not only holds significant promise for AKI, but also aims facilitate clinical application.

Язык: Английский

Molecular Strategies for Constructing Epoxy‐Type Afterglow Probes in Disease Diagnosis and Treatment DOI

Maocheng Zuo,

Yidan Hu,

L. Xiao

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.

Язык: Английский

Процитировано

0
Combination Diagnostics In Vivo: Dual-Mode Ultrasound/NIR Fluorescence Imaging with Neodymium- and Thulium-Doped Graphene Quantum Dots DOI
Alina Valimukhametova,

Olga Zub,

Natalia Castro-Lopez

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

The combination of two biomedical imaging techniques, fluorescence and ultrasound imaging, can uniquely offer enhanced anatomical visualization, sensitivity, specificity necessary for improved diagnostic accuracy in detecting small tumors, tracing therapeutic delivery, guiding biopsies. This work aims to harness the advantages highly deterministic deeply penetrating diagnostics neodymium- thulium-doped graphene quantum dot (Nd-NGQD Tm-NGQD) ultrasound/near-infrared (NIR) contrast agents. These biocompatible nanostructures are tested dual-mode fluorescence/ultrasound vivo live sedated BALB/c mice as well animal organs. Injected intravenously (IV), Tm-NGQDs Nd-NGQDs exhibit enhancement NIR liver, spleen, kidneys. best agreement is achieved between techniques liver at 12 h 24 h, spleen 6 kidneys Nd-NGQDs, suggesting optimal timeline imaging. IP-injected demonstrate a greater consistency within 1-48 time points all imaged Metal-doped GQD agents developed first this hold significant promise ultrasound-fluorescence paving way monitoring.

Язык: Английский

Процитировано

0
Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury DOI
Man Li, Lijuan Yang,

Yibo An

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Acute kidney injury (AKI) is a life-threatening condition characterized by rapid decline in the renal function, primarily caused oxidative stress, inflammation, and ferroptosis. Herein, we present selenium-doped carbon dots (Zt-SeCDs) that integrate antioxidant activity with controlled release of Zileuton, 5-lipoxygenase (ALOX5) inhibitor, under high reactive oxygen species (ROS) conditions. This nanoplatform can efficiently deliver leveraging its inherent properties to achieve targeted prevention treatment AKI. In vitro studies have confirmed Zt-SeCDs eliminate excessive ROS, prevent ferroptotic cell death, modulate inflammatory responses reducing expression key pro-inflammatory cytokines. Additionally, regulate ferroptosis through suppression ALOX5 upregulation glutathione peroxidase 4 (GPX4) expression. The significantly improves promotes regeneration damaged tissue, alleviates processes, death. Moreover, monitoring serum indicators observing pathological changes further potential preventing Notably, activate AMPK/FoxO1 signaling pathway, enhancing endogenous defenses protect tissue from damage. promising not only holds significant promise for AKI, but also aims facilitate clinical application.

Язык: Английский

Процитировано

0