Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
The
precise
spatiotemporal
control
of
reactive
oxygen
species
(ROS)
generation
and
scavenging
remains
pivotal
for
infected
wound
healing.
However,
conventional
nanozymes
fail
to
adaptively
regulate
ROS
dynamics
across
inflammatory
proliferative
phases.
A
near-infrared
(NIR)-activated
inverse
oxide/alloy-structured
nanozyme
(Co7Fe3/ZnO@C)
is
developed,
featuring
enzymatic
cascade
activities
tune
homeostasis
through
synergistic
chemodynamic
(CDT),
photodynamic
(PDT),
photothermal
(PTT)
therapies.
orchestrates
a
self-regulated
cascade:
peroxidase
(POD)-like
activity
initially
generates
bactericidal
hydroxyl
radicals
in
acidic
wounds,
while
subsequent
NIR
triggers
hot
electron
transfer
from
Co7Fe3
ZnO,
facilitating
synchronized
superoxide
dismutase
(SOD)-like,
catalase
(CAT)-like
radical
antioxidant
capacity
(HORAC)
scavenge
residual
ROS.
This
cascaded
network
dynamically
balances
production
(POD)
(NIR-driven
SOD/CAT/HORAC),
eradicating
bacteria
resolving
inflammation.
In
vitro/vivo
studies
have
shown
that
the
proposed
method
maintaining
can
markedly
enhance
rate
healing
by
regulation
environment
within
injured
tissue
facilitation
rapid
re-epithelialization.
work
provides
an
intelligent
platform
simulates
function
natural
enzymes
constructs
reaction
strategy
balance
antibacterial
anti-inflammatory
demands
microenvironment.
Язык: Английский
Hyaluronic acid and ZIF-8 nanocomposites for wound care
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144475 - 144475
Опубликована: Май 1, 2025
Язык: Английский
A cationic hydrogel for visual diagnosis and treatment of bacterial-infected wounds via mild, on-demand dual-phototherapy
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160984 - 160984
Опубликована: Фев. 1, 2025
Язык: Английский
Ultrasound-switchable piezoelectric BiVO4/fullerene heterostructure for on-demand ROS modulation in MRSA-infected diabetic wound healing
Biomaterials Advances,
Год журнала:
2025,
Номер
unknown, С. 214307 - 214307
Опубликована: Апрель 1, 2025
Язык: Английский
Macroporous hydrogel loaded with AIE-photosensitizer for enhanced antibacterial and wounds healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143977 - 143977
Опубликована: Май 1, 2025
Язык: Английский
Recent Advances in NIR-II Photothermal and Photodynamic Therapies for Drug-Resistant Wound Infections
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101871 - 101871
Опубликована: Май 14, 2025
Bacterial
infection
can
delay
wound
healing,
while
drug
resistance
further
complicates
the
treatment
of
infection.
Phototherapy,
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
is
a
non/mini-invasive
efficient
antibacterial
strategy
that
rarely
induces
bacterial
resistance.
This
relies
on
specific
wavelengths
light
to
activate
agents
(PTAs)
or
photosensitizers,
killing
bacteria
by
generating
local
heats
reactive
oxygen
species
(ROS),
respectively.
However,
for
traditional
PTT/PDT
mainly
falls
in
visible
near-infrared
I
(Vis/NIR-I
light,
400-900
nm)
regions,
which
significantly
limits
clinical
translations
due
its
low
tissue
permeability.
The
II
(NIR-II,1000-1700
increasingly
utilized
improve
penetration
ameliorate
immune
microenvironment
deeper
wounds.
Meanwhile,
NIR-II
offers
higher
maximum
permissible
exposure
(MPE)
treating
infections,
thereby
facilitating
security,
comparison
Vis/NIR-I
light.
review
highlights
recent
advancements
drug-resistant
focusing
mechanisms,
therapeutic
outcomes,
challenges,
prospects.
Язык: Английский