Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 11(1), С. 182 - 207

Опубликована: Дек. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Язык: Английский

Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release DOI
Yu Zhuang, Dingwei Wu,

Lvyang Zhou

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by distinctive characteristics of healing staged defects structure–function relationship natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) promote regeneration defects. Here, inner layer was using coaxial electrospinning fibers, with shell incorporating zinc oxide nanoparticles (ZnO NPs) core containing silicon dioxide (SiO2 mimicking cambium periosteum; outer consisted randomly aligned fibers loaded deferoxamine (DFO), simulating fibrous finally, epigallocatechin-3-gallate (EGCG) coated onto membrane obtain Bilayer@E. presence EGCG on Bilayer@E surface efficiently triggers phenotypic transition macrophages, shifting them from M1 proinflammatory state M2 anti-inflammatory state. Moreover, sequential release ZnO NPs, DFO, SiO2 NPs exhibits antimicrobial while coordinating angiogenesis promoting mineralization cells. Importantly, shows strong vivo tissue periosteal properties rats. integration drug immunomodulation, tailored meet specific requirements during regeneration, offers new insights for advancing application biomaterials this field.

Язык: Английский

Процитировано

0
A Narrative Review of Bioactive Hydrogel Microspheres: Ingredients, Modifications, Fabrications, Biological Functions, and Applications DOI Open Access
Haohui Li, Lili Yu, Ze Li

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract Hydrogel microspheres are important in regenerative medicine and tissue engineering, acting as cargos of cells, drugs, growth factors, bio‐inks for 3D printing, medical devices. The antimicrobial anti‐inflammatory characteristics hydrogel good treating injured tissues. However, the biological properties should be modified optimal treatment various body parts with different physiological biochemical environments. In addition, specific preparation methods required to produce customized shapes sizes clinical applications. Herein, advances biomedical applications reviewed. Synthesis precursor solutions, manufacturing methods, strategies enhancing functions these described. involvement bioactive repair is also discussed. This review anticipates fostering more insights into design, production, application biomedicine.

Язык: Английский

Процитировано

0
Metal-Free Antioxidant Nanozyme Incorporating Bioactive Hydrogel as an Antioxidant Scaffold for Accelerating Bone Reconstruction DOI
Yang Yang,

Qianrui Zeng,

Chaoyue Zhao

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123285 - 123285

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 11(1), С. 182 - 207

Опубликована: Дек. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Язык: Английский

Процитировано

1