Polydopamine-Modified Composite Bone Cement for Cancellous Bone Repair: Synergism of Bioactivity, Antibacterial Properties, and Biodegradability DOI

Yalan Ouyang,

Rongguang Zhang,

Qiyi Zhang

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Май 18, 2025

Infection-prone bone defects require multifunctional materials. We developed a novel degradable composite cement: polydopamine-modified calcium polyphosphate (CPP@PDA) combined with tricalcium silicate (C3S). CPP@PDA provides bioactivity and antibacterial effects, while C3S ensures sustained bioactive ion release. The cement exhibited >74% efficacy (Staphylococcus aureus, Escherichia coli), bacterial survival at 15.9 ± 1.2% 26.1 0.8%. Controlled degradation released Ca2+ silicon species, stimulating osteogenesis, shown by increased alkaline phosphatase (ALP) activity upregulated RUNX2, COL1, OPN markers. material also demonstrated antioxidant antiinflammatory properties, reducing oxidative stress modulating immune responses to support regeneration. This cement, synergistic antibacterial, biodegradable, osteogenic functionalities, shows significant potential for treating infection-prone cancellous defects.

Язык: Английский

Curcumin-Encapsulated Exosomes in Bisphosphonate-Modified Hydrogel Microspheres Promote Bone Repair through Macrophage Polarization and DNA Damage Mitigation DOI Creative Commons
Yunhui Si,

Shuao Dong,

Mengsha Li

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101874 - 101874

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Polydopamine-Modified Composite Bone Cement for Cancellous Bone Repair: Synergism of Bioactivity, Antibacterial Properties, and Biodegradability DOI

Yalan Ouyang,

Rongguang Zhang,

Qiyi Zhang

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Май 18, 2025

Infection-prone bone defects require multifunctional materials. We developed a novel degradable composite cement: polydopamine-modified calcium polyphosphate (CPP@PDA) combined with tricalcium silicate (C3S). CPP@PDA provides bioactivity and antibacterial effects, while C3S ensures sustained bioactive ion release. The cement exhibited >74% efficacy (Staphylococcus aureus, Escherichia coli), bacterial survival at 15.9 ± 1.2% 26.1 0.8%. Controlled degradation released Ca2+ silicon species, stimulating osteogenesis, shown by increased alkaline phosphatase (ALP) activity upregulated RUNX2, COL1, OPN markers. material also demonstrated antioxidant antiinflammatory properties, reducing oxidative stress modulating immune responses to support regeneration. This cement, synergistic antibacterial, biodegradable, osteogenic functionalities, shows significant potential for treating infection-prone cancellous defects.

Язык: Английский

Процитировано

0