808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue DOI

Baraka Joseph Butuyuyu,

Jiqiang Liu, Qihang Ding

и другие.

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Acute bacterial skin and structure infections (ABSSSIs) pose significant global health challenges, exacerbated by rising antibiotic resistance. Antibacterial photodynamic therapy (APDT) has emerged as a promising strategy to combat these utilizing photosensitizer (PS) that generates reactive oxygen species (ROS) upon light activation. However, the limited tissue penetration of conventional organic PSs, which primarily absorb in UV-vis spectra, hindered their therapeutic potential for deeper infections. Herein, we introduce novel iridium(III)-cyanine complex (Ir-cy) with strong near-infrared (NIR) absorption at 814 nm (up 101 red-shifted from previous reports), specifically designed enhance APDT. Under 808 laser irradiation, Ir-cy demonstrated substantial ROS generation capacity, achieving approximately 70% reduction Staphylococcus aureus (S. aureus) colonies depth 7.2 mm within simulated model. Comprehensive vitro vivo evaluations further confirmed its potent antibacterial efficacy against S. while maintaining excellent biocompatibility. These findings highlight highly effective NIR-active PS, paving way advanced strategies targeting deep-tissue ABSSSIs through optimized

Язык: Английский

Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy DOI Open Access

Minhui Cui,

Mengmeng Zhu, Dongsheng Tang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Язык: Английский

Процитировано

3
Nanoparticles, a promising treatment for gastric cancer DOI Creative Commons
Hua Dong, Xiexing Wu,

Zebin Wu

и другие.

Smart Materials in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue DOI

Baraka Joseph Butuyuyu,

Jiqiang Liu, Qihang Ding

и другие.

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Acute bacterial skin and structure infections (ABSSSIs) pose significant global health challenges, exacerbated by rising antibiotic resistance. Antibacterial photodynamic therapy (APDT) has emerged as a promising strategy to combat these utilizing photosensitizer (PS) that generates reactive oxygen species (ROS) upon light activation. However, the limited tissue penetration of conventional organic PSs, which primarily absorb in UV-vis spectra, hindered their therapeutic potential for deeper infections. Herein, we introduce novel iridium(III)-cyanine complex (Ir-cy) with strong near-infrared (NIR) absorption at 814 nm (up 101 red-shifted from previous reports), specifically designed enhance APDT. Under 808 laser irradiation, Ir-cy demonstrated substantial ROS generation capacity, achieving approximately 70% reduction Staphylococcus aureus (S. aureus) colonies depth 7.2 mm within simulated model. Comprehensive vitro vivo evaluations further confirmed its potent antibacterial efficacy against S. while maintaining excellent biocompatibility. These findings highlight highly effective NIR-active PS, paving way advanced strategies targeting deep-tissue ABSSSIs through optimized

Язык: Английский

Процитировано

0