Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances DOI Creative Commons
Xiaoman Li, Jianhua Tang,

Weiwei Guo

и другие.

Gels, Год журнала: 2025, Номер 11(3), С. 190 - 190

Опубликована: Март 8, 2025

In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research

Язык: Английский

Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances DOI Creative Commons
Xiaoman Li, Jianhua Tang,

Weiwei Guo

и другие.

Gels, Год журнала: 2025, Номер 11(3), С. 190 - 190

Опубликована: Март 8, 2025

In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research

Язык: Английский

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