Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease DOI Creative Commons
Rongrong Li,

Hongyan Tao,

Kai Pan

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Март 18, 2025

Diabetic kidney disease (DKD) is the leading cause of end-stage renal (ESRD) globally, presenting a significant therapeutic challenge. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) have emerged as promising agents. This study explored effects and mechanisms EVs derived human placental (hP-MSCs) on DKD. were isolated cultured hP-MSCs administered to streptozotocin (STZ)-induced diabetic mice high glucose–treated glomerular mesangial cells. The impact was assessed through histological analysis biochemical assays. miR-99b-5p expression in its role modulating mechanistic target rapamycin (mTOR)/autophagy pathway examined via western blotting RT‒qPCR. Treatment with hP-MSC-derived significantly alleviated fibrosis improved function DKD models. These enriched miR-99b-5p, which targeted inhibited mTOR signaling, thereby increasing autophagic activity reducing cellular proliferation extracellular matrix accumulation tissues. can mitigate injury by miR-99b-5p/mTOR/autophagy pathway. findings suggest potential cell-free strategy for managing

Язык: Английский

Study on the activity of targeted delivery of DOX against melanoma by exosome-like nanovesicles of Rhodiola rosea DOI
Meng Xu,

Meitao Duan,

Ming Chen

и другие.

Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2025, Номер unknown, С. 130776 - 130776

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Nanoparticle: Pathogenesis, Innovative Diagnosis, and Therapy of Liver Fibrosis DOI
Wen Lin, X Liu,

Dejun Yang

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(7)

Опубликована: Фев. 1, 2025

Abstract Liver fibrosis, a progressive condition resulting from chronic liver injury, can lead to cirrhosis and hepatocellular carcinoma. Nanoparticles have emerged as promising tools for their diagnosis treatment due unique properties. This review highlights advances in lipid‐based (e.g., liposomes, solid lipid nanoparticles), polymer‐based nanocapsules, dendrimers), inorganic iron oxide, gold biological nanoparticles extracellular vesicles, exosomes). These enhance imaging contrast MRI CT, enabling non‐invasive fibrosis detection, deliver drugs or gene‐editing hepatic stellate cells (HSCs) targeted therapy. Extracellular vesicles (EVs) exosomes also show potential biomarkers therapeutic carriers. However, challenges such limited targeting efficiency, toxicity, difficulties clinical translation remain. Future research should focus on optimizing nanoparticle design, improving biocompatibility, addressing regulatory issues facilitate application. Nanoparticle‐based strategies hold great promise revolutionizing management.

Язык: Английский

Процитировано

0
Extracellular vesicles derived from mesenchymal stem cells alleviate renal fibrosis via the miR-99b-5p/mTOR/autophagy axis in diabetic kidney disease DOI Creative Commons
Rongrong Li,

Hongyan Tao,

Kai Pan

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Март 18, 2025

Diabetic kidney disease (DKD) is the leading cause of end-stage renal (ESRD) globally, presenting a significant therapeutic challenge. Extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) have emerged as promising agents. This study explored effects and mechanisms EVs derived human placental (hP-MSCs) on DKD. were isolated cultured hP-MSCs administered to streptozotocin (STZ)-induced diabetic mice high glucose–treated glomerular mesangial cells. The impact was assessed through histological analysis biochemical assays. miR-99b-5p expression in its role modulating mechanistic target rapamycin (mTOR)/autophagy pathway examined via western blotting RT‒qPCR. Treatment with hP-MSC-derived significantly alleviated fibrosis improved function DKD models. These enriched miR-99b-5p, which targeted inhibited mTOR signaling, thereby increasing autophagic activity reducing cellular proliferation extracellular matrix accumulation tissues. can mitigate injury by miR-99b-5p/mTOR/autophagy pathway. findings suggest potential cell-free strategy for managing

Язык: Английский

Процитировано

0