Fluorescence and photothermal dual-modal image guided integrated diagnosis and treatment DOI
Wan Sun, Xuefeng Wang, Fan Yang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 254, С. 114828 - 114828

Опубликована: Май 27, 2025

Язык: Английский

NIR-II Light-Modulated Smart Drug Delivery System Utilizing Drug-Gated Nanocomposite Hydrogel for Boosting Anticancer Efficacy DOI Creative Commons

Jiamei Gu,

Shangwen Zhang,

Yuan Jiawei

и другие.

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Май 3, 2025

Язык: Английский

Процитировано

0
A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy DOI
Guanru Wang, Hao Guo,

Mengxin Wei

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Chemotherapy for glioblastoma (GBM) has not achieved the desired outcome due to inefficient blood-brain barrier (BBB) penetration and limited tumor-specific drug accumulation. Strategies that employ bioinspired nanoparticles enhance targeted accumulation can help improve therapeutic efficacy. In this work, a novel nanoparticle, PCM@TMA-lip, exhibiting hybrid-targeting capabilities, is presented, with an engineered cell membrane coated on lipid core. The modified biologically derived peptide enables PCM@TMA-lip evade immune clearance enable precise tumor targeting. core docosahexaenoic acid (DHA)-conjugated Temozolomide (TMZ) enhances FABP7-mediated uptake, promotes lysosomal escape via peroxidation, reduces migration resistance. vitro, inhibited malignancy suppressed growth of 3D spheroids. vivo, it progression, reduced Ki67+ proliferation, increased TUNEL+ apoptosis, prolonged survival in GBM-bearing mice, highlighting its potential as effective strategy GBM chemotherapy.

Язык: Английский

Процитировано

0
Recent advances in nanomaterial-based brain-targeted delivery systems for glioblastoma therapy DOI

Mingyue Qu,

Quan Wang, Xinying Wang

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Май 12, 2025

Glioblastoma (GBM) poses a formidable challenge because of its high morbidity and mortality. The therapeutic efficacy GBM is significantly hampered by the intricate blood-brain barrier (BBB) tumor (BBTB). Nanomaterial-based brain-targeted delivery systems have shown great potential for effectively delivering agents treatment overcoming limitations conventional drugs, such as poor BBB penetration, short half-life, low bioavailability. This review focuses on an in-depth analysis interplay between BBB/BBTB drug transport kinetics while analyzing innovative nanoparticle-mediated strategies enhanced treatment. Moreover, nanoparticle-based are emphasized, with particular attention given to biomimetic nanoparticles (BMNPs), whose unique advantages. current challenges, translational potential, future research directions in this rapidly evolving field comprehensively discussed, highlighting advances nanomaterial applications. aims stimulate further into systems, offering promising avenues maximizing effects gene drugs or chemotherapeutic practical

Язык: Английский

Процитировано

0
In Vivo Visualization of Tumor Metabolic Activity with a Tetra Glucose-Conjugated Zinc-Phthalocyanine Photoacoustic Contrast DOI Creative Commons

Pooja Annasaheb Patkulkar,

Arjun SV,

Ananya Sharma

и другие.

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

0
Fluorescence and photothermal dual-modal image guided integrated diagnosis and treatment DOI
Wan Sun, Xuefeng Wang, Fan Yang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 254, С. 114828 - 114828

Опубликована: Май 27, 2025

Язык: Английский

Процитировано

0