High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations

Biosensors, Год журнала: 2025, Номер 15(4), С. 242 - 242

Опубликована: Апрель 11, 2025

Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, increasing evidence suggests that environmental pollutants can significantly accelerate this interfering with oxidative stress, neuroinflammation, mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of macromolecules (e.g., proteins, DNA), while central role senescence-associated small molecules ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In study, we innovatively proposed cascade framework "small molecule imbalance-signaling pathway dysregulation-macromolecule collapse", which reveals exacerbate dynamics brain through activation NLRP3 inflammatory vesicles inhibition HIF-1α. Meanwhile, to address technical bottleneck spatiotemporal monitoring, paper systematically reviews cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages real-time monitoring ROS fluctuations intervention virtue their ultra-high specific surface area, controllable modification, free radical scavenging ability. By integrating multimodal techniques mechanism studies, work provides new perspective for analyzing pollutant-induced lays methodological foundation strategies based networks.

Язык: Английский

MXene/Carbon Dot Nanocomposites with Photothermal/Physical Synergistic Antibacterial Capability for Wound Healing

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

Engineering M2 macrophage-derived exosome-loaded PEG hydrogels for preventing pancreatic leakage and facilitating anastomotic healing

Chemical Engineering Journal, Год журнала: 2025, Номер 516, С. 164164 - 164164

Опубликована: Май 27, 2025

Язык: Английский