Vaccines, Год журнала: 2025, Номер 13(5), С. 478 - 478

Опубликована: Апрель 29, 2025

Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, has been robustly linked to the pathogenesis of nasopharyngeal carcinoma (NPC). The mechanism EBV-induced NPC involves complex interactions between viral proteins and host cell pathways. This review aims comprehensively outline latest advances in targeted EBV vaccines for prophylaxis treatment. explores intricate molecular mechanisms by which contributes pathogenesis, highlighting latency, genetic epigenetic alterations, immune evasion strategies. It emphasizes pivotal role key proteins, including EBNA1, LMP1, LMP2A, carcinogenesis. Subsequently, discussion shifts towards development vaccines, preventive aimed at preventing primary infection therapeutic treating diagnosed EBV-related NPC. underscores challenges future directions field, stressing importance developing innovative vaccine strategies combination therapies improve efficacy. synthesizes current insights into EBV-targeted potential use mRNA

Язык: Английский