Selenium‐Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti‐Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
14(13)
Опубликована: Апрель 15, 2025
Abstract
Wounds
repairing
after
skin
damage
or
diabetes
remain
a
vast
medical
challenge,
which
often
faces
infection,
inflammation,
oxidative
stress,
and
scarring.
Herein,
multifunctional
selenium‐albumin
nanoaccelerator
hydrogel
(H‐Se
NPs‐Gel)
is
constructed
based
on
the
self‐assembly
of
human
serum
albumin
(HSA)
with
selenium
nanoparticles
(Se
NPs)
using
carbomer
as
carrier,
it
has
remarkable
antibacterial,
anti‐inflammatory,
antioxidant
inhibits
scarring
properties
than
Se
NPs
for
wound
healing.
Compared
NPs,
H‐Se
exhibit
smaller
particle
sizes,
exceptional
stability,
better
antibacterial
activity
against
common
bacteria
MRSA,
superior
anti‐inflammatory
capabilities
in
vitro
without
toxicity
cells.
Importantly,
exhibits
efficacy
to
NPs‐Gel
accelerating
healing
full‐thickness
defects
diabetic
wounds
mice.
Interestingly,
hypertrophic
scar
(HTS)
model,
more
effective
inhibiting
collagen
formation
suppress
scarring,
mediated
by
inhibition
CD36.
The
antagonistic
effect
CD36
also
proved
overexpression
model.
Furthermore,
demonstrates
excellent
safety
mice
systemic
toxicity.
an
safe
therapy
strategy
promoting
reducing
clinic.
Язык: Английский
Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics
Gels,
Год журнала:
2025,
Номер
11(6), С. 383 - 383
Опубликована: Май 23, 2025
Injectable
biopolymer-based
hydrogels
have
emerged
as
a
powerful
class
of
biomaterials
designed
for
minimally
invasive
therapeutic
strategies
in
modern
medicine.
These
smart
hydrogels,
derived
from
natural
biopolymers,
such
alginate,
chitosan,
gelatin,
hyaluronic
acid,
and
collagen,
offer
unique
advantages,
including
biocompatibility,
biodegradability,
the
ability
to
mimic
extracellular
matrix.
This
review
provides
comprehensive
overview
recent
advancements
design,
crosslinking
mechanisms,
biofunctionality
injectable
tailored
targeted
drug
delivery
tissue
regeneration.
Special
attention
is
given
their
role
situ
gelling
systems,
cancer
therapy,
musculoskeletal
repair,
neural
Challenges
related
mechanical
strength,
degradation
control,
clinical
translation
are
also
discussed,
along
with
future
perspectives
scalable
manufacturing
regulatory
approval.
Язык: Английский