Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 383 - 383

Опубликована: Май 23, 2025

Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, the ability to mimic extracellular matrix. This review provides comprehensive overview recent advancements design, crosslinking mechanisms, biofunctionality injectable tailored targeted drug delivery tissue regeneration. Special attention is given their role situ gelling systems, cancer therapy, musculoskeletal repair, neural Challenges related mechanical strength, degradation control, clinical translation are also discussed, along with future perspectives scalable manufacturing regulatory approval.

Язык: Английский

Selenium‐Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti‐Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36 DOI

Lulu Zhao,

Junyi Wang, Yu Pan

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер 14(13)

Опубликована: Апрель 15, 2025

Abstract Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and scarring. Herein, multifunctional selenium‐albumin nanoaccelerator hydrogel (H‐Se NPs‐Gel) is constructed based on the self‐assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as carrier, it has remarkable antibacterial, anti‐inflammatory, antioxidant inhibits scarring properties than Se NPs for wound healing. Compared NPs, H‐Se exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria MRSA, superior anti‐inflammatory capabilities in vitro without toxicity cells. Importantly, exhibits efficacy to NPs‐Gel accelerating healing full‐thickness defects diabetic wounds mice. Interestingly, hypertrophic scar (HTS) model, more effective inhibiting collagen formation suppress scarring, mediated by inhibition CD36. The antagonistic effect CD36 also proved overexpression model. Furthermore, demonstrates excellent safety mice systemic toxicity. an safe therapy strategy promoting reducing clinic.

Язык: Английский

Процитировано

0

Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 383 - 383

Опубликована: Май 23, 2025

Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, the ability to mimic extracellular matrix. This review provides comprehensive overview recent advancements design, crosslinking mechanisms, biofunctionality injectable tailored targeted drug delivery tissue regeneration. Special attention is given their role situ gelling systems, cancer therapy, musculoskeletal repair, neural Challenges related mechanical strength, degradation control, clinical translation are also discussed, along with future perspectives scalable manufacturing regulatory approval.

Язык: Английский

Процитировано

0