Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11149 - 11193
Опубликована: Июнь 30, 2021
Owing
to
their
unique
chemical
and
physical
properties,
hydrogels
are
attracting
increasing
attention
in
both
basic
translational
biomedical
studies.
Although
the
classical
with
static
networks
have
been
widely
reported
for
decades,
a
growing
number
of
recent
studies
shown
that
structurally
dynamic
can
better
mimic
dynamics
functions
natural
extracellular
matrix
(ECM)
soft
tissues.
These
synthetic
materials
defined
compositions
recapitulate
key
biophysical
properties
living
tissues,
providing
an
important
means
understanding
mechanisms
by
which
cells
sense
remodel
surrounding
microenvironments.
This
review
begins
overall
expectation
design
principles
hydrogels.
We
then
highlight
progress
fabrication
strategies
including
degradation-dependent
degradation-independent
approaches,
followed
use
applications
such
as
regenerative
medicine,
drug
delivery,
3D
culture.
Finally,
challenges
emerging
trends
development
application
discussed.
Journal of the American Chemical Society,
Год журнала:
2014,
Номер
136(29), С. 10174 - 10185
Опубликована: Июнь 26, 2014
In
this
Perspective,
we
discuss
the
recent
development
of
polymerization-induced
self-assembly
mediated
by
reversible
addition-fragmentation
chain
transfer
(RAFT)
aqueous
dispersion
polymerization.
This
approach
has
quickly
become
a
powerful
and
versatile
technique
for
synthesis
wide
range
bespoke
organic
diblock
copolymer
nano-objects
controllable
size,
morphology,
surface
functionality.
Given
its
potential
scalability,
such
environmentally-friendly
formulations
are
expected
to
offer
many
applications,
as
novel
Pickering
emulsifiers,
efficient
microencapsulation
vehicles,
sterilizable
thermo-responsive
hydrogels
cost-effective
long-term
storage
mammalian
cells.
Materials Science and Engineering R Reports,
Год журнала:
2020,
Номер
140, С. 100543 - 100543
Опубликована: Фев. 18, 2020
3D
printing
alias
additive
manufacturing
can
transform
virtual
models
created
by
computer-aided
design
(CAD)
into
physical
objects
in
a
layer-by-layer
manner
dispensing
with
conventional
molding
or
machining.
Since
the
incipiency,
significant
advancements
have
been
achieved
understanding
process
of
and
relationship
component,
structure,
property
application
objects.
Because
hydrogels
are
one
most
feasible
classes
ink
materials
for
this
field
has
rapidly
advancing,
Review
focuses
on
hydrogel
designs
development
advanced
hydrogel-based
biomaterial
inks
bioinks
printing.
It
covers
techniques
including
laser
(stereolithography,
two-photon
polymerization),
extrusion
(3D
plotting,
direct
writing),
inkjet
printing,
bioprinting,
4D
bioprinting.
provides
comprehensive
overview
discussion
tailorability
material,
mechanical,
physical,
chemical
biological
properties
to
enable
The
range
hydrogel-forming
polymers
covered
encompasses
biopolymers,
synthetic
polymers,
polymer
blends,
nanocomposites,
functional
cell-laden
systems.
representative
biomedical
applications
selected
demonstrate
how
is
being
exploited
tissue
engineering,
regenerative
medicine,
cancer
research,
vitro
disease
modeling,
high-throughput
drug
screening,
surgical
preparation,
soft
robotics
flexible
wearable
electronics.
Incomparable
thermoplastics,
thermosets,
ceramics
metals,
playing
pivotal
role
creation
(bio)systems
customizable
way.
An
outlook
future
directions
presented.
Advanced Materials,
Год журнала:
2018,
Номер
30(50)
Опубликована: Авг. 2, 2018
Soft
electronics
are
intensively
studied
as
the
integration
of
with
dynamic
nonplanar
surfaces
has
become
necessary.
Here,
a
discussion
strategies
in
materials
innovation
and
structural
design
to
build
soft
electronic
devices
systems
is
provided.
For
each
strategy,
presentation
focuses
on
fundamental
science
mechanics,
example
device
applications
highlighted
where
possible.
Finally,
perspectives
key
challenges
future
directions
this
field
presented.
Advanced Materials,
Год журнала:
2016,
Номер
28(33), С. 7178 - 7184
Опубликована: Июнь 14, 2016
Soak
n'
Boost:
A
universal
strategy
to
manufacture
hybrid
double-network
hydrogels
with
eminent
mechanical
properties
is
developed
by
postformation
of
the
chitosan
microcrystalline
and
chain-entanglement
physical
networks
via
simple
treatment
composite
using
alkaline
saline
solutions.
The
may
open
an
avenue
fabricate
multifarious
for
promising
applications
in
antifouling
materials,
drug
delivery,
tissue
engineering.
Tissue Engineering Part B Reviews,
Год журнала:
2014,
Номер
20(6), С. 683 - 696
Опубликована: Июнь 13, 2014
Type
I
collagen
hydrogels
have
been
used
successfully
as
three-dimensional
substrates
for
cell
culture
and
shown
promise
scaffolds
engineered
tissues
tumors.
A
critical
step
in
the
development
of
viable
tissue
mimics
is
quantitative
characterization
hydrogel
properties
their
correlation
with
fabrication
parameters,
which
enables
to
be
tuned
match
specific
or
fulfill
engineering
requirements.
significant
body
work
has
devoted
hydrogels;
however,
due
breadth
materials
techniques
characterization,
published
data
are
often
disjoint
hence
utility
community
reduced.
This
review
aims
determine
parameter
space
covered
by
existing
identify
key
gaps
literature
so
that
future
use
research
can
most
efficiently
conducted.
divided
into
three
sections:
(1)
relevant
parameters
introduced
several
popular
methods
controlling
regulating
them
described,
(2)
presented
discussed
along
techniques,
(3)
state
recapitulated
directions
proposed.
Ultimately,
this
serve
a
resource
selection
material
methodologies
order
increase
usefulness
collagen-hydrogel-based
studies
experiments.
Chemical Reviews,
Год журнала:
2022,
Номер
122(6), С. 5604 - 5640
Опубликована: Янв. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
