Cell Membrane Coated Semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics

ACS Nano, Год журнала: 2018, Номер 12(8), С. 8520 - 8530

Опубликована: Авг. 2, 2018

Phototheranostic nanoagents are promising for early diagnosis and precision therapy of cancer. However, their imaging ability therapeutic efficacy often limited due to the presence delivery barriers in tumor microenvironment. Herein, we report development organic multimodal phototheranostic that can biomimetically target cancer-associated fibroblasts microenvironment enhanced imaging-guided cancer therapy. Such biomimetic nanocamouflages comprise a near-infrared (NIR) absorbing semiconducting polymer nanoparticle (SPN) coated with cell membranes activated fibroblasts. The homologous targeting mechanism allows fibroblast membrane SPN (AF-SPN) specifically fibroblasts, leading accumulation relative uncoated counterparts after systemic administration living mice. As such, AF-SPN not only provides stronger NIR fluorescence photoacoustic signals detect tumors but also generates cytotoxic heat singlet oxygen exert combinational photothermal photodynamic therapy, ultimately an antitumor higher than counterparts. This study introduces system targets component theranostics.

Язык: Английский

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Recent Progresses in Phototherapy‐Synergized Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2018, Номер 28(46)

Опубликована: Сен. 20, 2018

Abstract Cancer immunotherapy has recently gained much attention in the search of cancer cure due to its ability “train” immune system seeking out and removing residual tumor cells. However, relying on alone may fail ablate primary tumors. Phototherapy is a promising modality that offers an elegant solution eradicate tumors through simple application light irradiation meanwhile triggers responses by immunogenic cell death enhance antitumor immunity. Uniting phototherapy with been found achieve synergistic outcomes, promote regression, even attain immunologic memory. This review summarizes recent studies utilizing combinatorial approaches treat cancer. A variety nanoplatforms have investigated combination immunoadjuvants checkpoint blockades such as CTLA4 PD‐L1 pathways. Higher levels proinflammatory cytokines, improved migration dendritic cells, increased ratio tumor‐infiltrating cytotoxic T cells against regulatory are revealed many studies, offering glimpse into mechanistic principles. Future advancements targeting different checkpoints could offer better immunosuppression coupled other phototherapeutic strategies remain be explored accomplishing complete elimination

Язык: Английский

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Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

Advanced Materials, Год журнала: 2019, Номер 31(11)

Опубликована: Янв. 21, 2019

Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1700 nm) holds great promise for deep-tissue diagnosis due to reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive technique is greatly constrained by lack biodegradable NIR-II absorbing agents. Herein, first series metabolizable PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist π-conjugated yet oxidizable optical as generator hydrolyzable amphiphilic particle matrix provide water solubility. The obtained SPNs readily degraded myeloperoxidase lipase abundant phagocytes, transforming from nonfluorescent (30 into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these can be effectively cleared out via both hepatobiliary renal excretions after systematic administration, leaving no toxicity living mice. Particularly possess high photothermal conversion efficiencies emit bright signals at 1064 nm, enabling sensitive subcutaneous tumor deep brain vasculature through intact skull animals low dosage. This study thus provides generalized molecular design toward materials biophotonic applications window.

Язык: Английский

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Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in the NIR‐II Biowindow

Advanced Materials, Год журнала: 2020, Номер 32(33)

Опубликована: Июль 6, 2020

Abstract Extensive recent progress has been made on the design and applications of organic photothermal agents for biomedical because their excellent biocompatibility comparing with inorganic materials. One major hurdle further development is rarity high‐performance materials in second near‐infrared (NIR‐II) window, which allows deep tissue penetration causes minimized side effects. Up till now, there have few reported NIR‐II‐active conversion efficiencies are relatively low. Herein, optical absorption π‐conjugated small molecules from first NIR window to NIR‐II precisely regulated by molecular surgery substituting an individual atom. With this technique, demonstration a conjugated oligomer (IR‐SS) peak beyond 1000 nm presented, its nanoparticle achieves record‐high efficiency 77% under 1064 excitation. The nanoparticles show good photoacoustic response, therapeutic efficacy, vitro vivo. This work develops strategy boost light‐harvesting cancer theranostics, offering important step forward advancing application agents.

Язык: Английский

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Yolk–Shell Structured Au Nanostar@Metal–Organic Framework for Synergistic Chemo-photothermal Therapy in the Second Near-Infrared Window

Nano Letters, Год журнала: 2019, Номер 19(10), С. 6772 - 6780

Опубликована: Сен. 9, 2019

Light-sensitive yolk–shell nanoparticles (YSNs) as remote-controlled and stimuli-responsive theranostic platforms provide an attractive method for synergistic cancer therapy. Herein, a kind of novel multifunctional YSNs has been successfully constructed by integrating star-shaped gold (Au star) the second near-infrared (NIR-II) photothermal yolks biodegradable crystalline zeolitic imidazolate framework-8 (ZIF-8) shells. In this platform, chemotherapeutic drug (doxorubicin hydrochloride, DOX) was encapsulated into cavity, which can show behavior controlled release due to degradation process ZIF-8 in mildly acidic tumor microenvironment. Upon 1064 nm (NIR-II biowindow) laser irradiation, nanostar@ZIF-8 (Au@MOF) exhibited outstanding anticancer effect based on their promoted cargo properties. Moreover, strong NIR region absorbance endows Au@MOF thermal imaging photoacoustic (PA) This work contributes design "all-in-one" nanocarrier that realizes bimodal diagnosis chemo-photothermal

Язык: Английский

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