Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

---

Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Год журнала: 2020, Номер 53(4), С. 752 - 762

Опубликована: Фев. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Язык: Английский

---

Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Март 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Язык: Английский

---

Atomic‐Precision Gold Clusters for NIR‐II Imaging

Advanced Materials, Год журнала: 2019, Номер 31(46)

Опубликована: Окт. 1, 2019

Near-infrared II (NIR-II) imaging at 1100-1700 nm shows great promise for medical diagnosis related to blood vessels because it possesses deep penetration and high resolution in biological tissue. Unfortunately, currently available NIR-II fluorophores exhibit slow excretion low brightness, which prevents their potential applications. An atomic-precision gold (Au) cluster with 25 atoms 18 peptide ligands is presented. The Au25 clusters show emission 1100-1350 the fluorescence quantum yield significantly increased by metal-atom doping. Bright can penetrate tissue be applied vivo brain vessel tumor metastasis. Time-resolved blood-flow significant differences between healthy injured mice different diseases vivo. High-resolution of cancer metastasis allows identification primary tumor, vessel, lymphatic In addition, are used monitor high-resolution kidney a depth 0.61 cm, quantitative measurement 86% cleared from body without any acute or long-term toxicity dose 100 mg kg-1 .

Язык: Английский

---

NIR‐II AIEgens: A Win–Win Integration towards Bioapplications

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(14), С. 7476 - 7487

Опубликована: Июнь 9, 2020

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.

Язык: Английский

---

All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy

Advanced Functional Materials, Год журнала: 2019, Номер 29(31)

Опубликована: Май 23, 2019

Abstract Development of single near‐infrared (NIR) laser triggered phototheranostics for multimodal imaging guided combination therapy is highly desirable but still a big challenge. Herein, novel small‐molecule dye DPP‐BT designed and synthesized, which shows strong absorption in the first NIR window (NIR‐I) fluorescence emission second region (NIR‐II). Such not only acts as dual‐modal contrast agent NIR‐II photoacoustic (PA) imaging, also serves combined therapeutic photothermal (PTT) photodynamic (PDT). The all‐in‐one phototheranostic nanoparticles are constructed by encapsulating DPP‐BT, chemotherapy drug DOX, natural phase‐change materials with folic acid functionalized amphiphile. Notably, under irradiation, DOX can effectively release from such via NIR‐induced hyperthermia DPP‐BT. By intravenous injection into Hela tumor‐bearing mice, tumor size location be accurately observed fluorescence/PA imaging. From vitro vivo results, simultaneously present remarkable antitumor efficacy PTT/PDT/chemo therapy, laser. Overall, this work provides an innovative strategy to design construct nanoplatforms clinical phototheranostics.

Язык: Английский

---

A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(18), С. 5920 - 5924

Опубликована: Фев. 22, 2019

Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1 O2 ) under NIR photoirradiation but also specifically activates chemotherapeutic action in hypoxic microenvironment. SPNpd self-assembled from amphiphilic brush, which comprises light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated chemodrug through hypoxia-cleavable linkers. The well-defined compact nanostructure (30 nm) enables accumulation living mice. Owing to these features, exerts synergistic chemo-therapy, effectively inhibits growth xenograft mouse model. This study represents first hypoxia-activatable phototherapeutic polymeric prodrug system high potential therapy.

Язык: Английский

---

Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

Advanced Materials, Год журнала: 2019, Номер 31(11)

Опубликована: Янв. 21, 2019

Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1700 nm) holds great promise for deep-tissue diagnosis due to reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive technique is greatly constrained by lack biodegradable NIR-II absorbing agents. Herein, first series metabolizable PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist π-conjugated yet oxidizable optical as generator hydrolyzable amphiphilic particle matrix provide water solubility. The obtained SPNs readily degraded myeloperoxidase lipase abundant phagocytes, transforming from nonfluorescent (30 into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these can be effectively cleared out via both hepatobiliary renal excretions after systematic administration, leaving no toxicity living mice. Particularly possess high photothermal conversion efficiencies emit bright signals at 1064 nm, enabling sensitive subcutaneous tumor deep brain vasculature through intact skull animals low dosage. This study thus provides generalized molecular design toward materials biophotonic applications window.

Язык: Английский

---

Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics

Theranostics, Год журнала: 2020, Номер 10(14), С. 6278 - 6309

Опубликована: Янв. 1, 2020

Multifunctional magnetic nanoparticles and derivative nanocomposites have aroused great concern for multimode imaging cancer synergistic therapies in recent years.Among the rest, functional iron oxide (Fe3O4 NPs) shown potential as an advanced platform because of their inherent resonance (MRI), biocatalytic activity (nanozyme), hyperthermia treatment (MHT), photo-responsive therapy drug delivery chemotherapy gene therapy.Magnetic Fe3O4 NPs can be synthesized through several methods easily surface modified with biocompatible materials or active targeting moieties.The MRI capacity could appropriately modulated to induce response between T1 T2 modes by controlling size distribution NPs.Besides, small-size are also desired due enhanced permeation retention (EPR) effect, thus therapeutic efficiency NP-based platforms further improved.Here, we firstly retrospect typical synthesis modification NPs.Then, latest biomedical application including responsive MRI, multimodal imaging, nanozyme, MHT, delivery, mechanism corresponding treatments cooperation therapeutics multifunctional explained.Finally, outline a brief discussion perspective on possibility clinical translations these nanomaterials.This review would provide comprehensive reference readers understand diagnosis treatment.

Язык: Английский

---

Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

ACS Applied Bio Materials, Год журнала: 2018, Номер 1(6), С. 1768 - 1786

Опубликована: Окт. 30, 2018

The emergence of the aggregation-induced emission (AIE) concept significantly changes cognition scientific community toward classic photophysical phenomena. More importantly, AIE phenomenon has brought huge opportunities for analysis bioactive species, monitoring complicated biological processes, and elucidation key physiological pathological behaviors. As a class promising luminescent materials, luminogens (AIEgens) are weakly or non-emissive in form isolated molecular species but emit particularly strong fluorescence aggregated solid states. Motivated by prominent advantages such as high brightness, large Stokes shift, excellent photostability, good biocompatibility, AIEgen-based bioprobes have been widely explored field biomedicine. This review aims to provide systematic summary developmental history an in-depth perspective current landscape biomedical field, with emphasis on discussions major working principles. milestones historical development first reviewed. A total four research directions then extracted, including biomacromolecule sensing (at level), vitro cell imaging cellular vivo animal cancer theranostics levels), together clear-cut tables showing comprehensive cases further study. Lastly, this is concluded several perspectives future directions. It believed that will play vital roles exploration mysterious life processes integration various cutting-edge modalities techniques ultimate goal addressing more healthcare issues.

Язык: Английский

---