Immunomodulatory Nanosystems

Advanced Science, Год журнала: 2019, Номер 6(17)

Опубликована: Июнь 21, 2019

Abstract Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety diseases, including cancer, infectious inflammatory autoimmune diseases. Immunomodulatory nanosystems can readily improve therapeutic effects simultaneously overcome many obstacles facing method, such inadequate immune stimulation, off‐target side effects, bioactivity loss agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, functions. This Review provides most advances nanotechnology immunostimulation immunosuppression. cancer immunotherapy, play essential role in cell activation tumor microenvironment modulation, well combination other antitumor approaches. encouraging outcomes from using nanomaterial vaccines against viral bacterial infections been reported. addition, nanoparticles also potentiate immunosuppressive cells Finally, challenges prospects applying to modulate immunotherapy are discussed.

Язык: Английский

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Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

Nano-Micro Letters, Год журнала: 2019, Номер 11(1)

Опубликована: Ноя. 16, 2019

Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell properties, and active area ongoing research readily applicable nanoscale biomedicine. Nanoparticles (NPs) coated with membranes offer opportunity unite natural properties those artificial inner core material. The NPs not only increase their biocompatibility but also achieve effective extended circulation in vivo, allowing for execution targeted functions. Although membrane-coated clear advantages, much work remains before they can be applied clinical practice. In this review, we first provide a comprehensive overview theory technology, followed by summary existing preparation characterization techniques. Next, focus on functions applications various types. addition, collate model drugs used review patent related from past 10 years. Finally, survey future challenges trends pertaining effort development technology.

Язык: Английский

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Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

Nano Letters, Год журнала: 2020, Номер 20(7), С. 5570 - 5574

Опубликована: Июнь 17, 2020

We report cellular nanosponges as an effective medical countermeasure to the SARS-CoV-2 virus. Two types of are made plasma membranes derived from human lung epithelial type II cells or macrophages. These display same protein receptors, both identified and unidentified, required by for entry. It is shown that, following incubation with nanosponges, neutralized unable infect cells. Crucially, nanosponge platform agnostic viral mutations potentially species, well. As long target virus remains host cell, will be able neutralize

Язык: Английский

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Engineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation

Advanced Science, Год журнала: 2019, Номер 6(15)

Опубликована: Май 22, 2019

Abstract Inflammation is ubiquitous in the body, triggering desirable immune response to defend against dangerous signals or instigating undesirable damage cells and tissues cause disease. Nanomedicine holds exciting potential modulating inflammation. In particular, cell membranes derived from involved inflammatory process may be used coat nanotherapeutics for effective targeted delivery tissues. Herein, recent progress of rationally engineering membrane‐based inflammation therapy highlighted, challenges opportunities presented realizing full cell‐membrane coating targeting manipulating microenvironment are discussed.

Язык: Английский

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Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal

Science Advances, Год журнала: 2020, Номер 6(16)

Опубликована: Апрель 17, 2020

The design of next-generation nanobiomaterials requires precise engineering both physical properties the core material and chemical material's surface to meet a biological function. A bio-inspired modular versatile technology was developed allow biodegradable polymeric nanoparticles circulate through blood for extended periods time while also acting as detoxification device. To mimic red cells, biomimicry are combined enhance function nanomaterials in vitro vivo. anisotropic shape membrane coating synergize resist cellular uptake reduce clearance from blood. This approach enhances nanoparticles, markedly improving survival mouse model sepsis. membrane-coated have enhanced biodistribution therapeutic efficacy. These biomimetic nanodevices their derivatives promise applications ranging agents, drug delivery vehicles, sensors.

Язык: Английский

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Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy

Journal of Controlled Release, Год журнала: 2020, Номер 327, С. 546 - 570

Опубликована: Сен. 8, 2020

Язык: Английский

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Nanoparticle-Based Strategies to Combat COVID-19

ACS Applied Nano Materials, Год журнала: 2020, Номер 3(9), С. 8557 - 8580

Опубликована: Авг. 26, 2020

Coronavirus disease 2019 (COVID-19) is the worst pandemic of current millennium. This caused by highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first exhibited human-to-human transmission in December and has infected millions people within months across 213 different countries. Its ability to be transmitted asymptomatic carriers put a massive strain on currently available testing resources. Currently, there are no clinically proven therapeutic methods that clearly inhibit effects this virus, COVID-19 vaccines still development phase. Strategies need explored expand capacities, develop effective therapeutics, safe provide lasting immunity. Nanoparticles (NPs) have been widely used many medical applications, such as biosensing, drug delivery, imaging, antimicrobial treatment. SARS-CoV-2 an enveloped virus with particle-like characteristics diameter 60–140 nm. Synthetic NPs can closely mimic interact strongly its proteins due their morphological similarities. Hence, NP-based strategies for tackling immense potential. previously found tools against viruses, especially those from Coronaviridae family. Review outlines role diagnostics, vaccination other two epidemic coronaviruses, 2003 (SARS) 2012 Middle East (MERS) virus. We also highlight nanomaterial-based approaches address human coronaviruses (HCoVs); feline (FCoV); avian infectious bronchitis (IBV); models, porcine diarrhea (PEDV), reproductive (PRRSV), transmissible gastroenteritis (TGEV); viruses share similarities SARS-CoV-2. combines salient principles previous antiviral studies recent research conducted outline combat similar pandemics future.

Язык: Английский

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Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 30(39)

Опубликована: Авг. 9, 2020

Abstract Surface modification of nanomaterials is essential for their biomedical applications owing to passive immune clearance and damage reticuloendothelial systems. Recently, a cell membrane‐coating technology has been proposed as an ideal approach modify its facile functionalized process good biocompatibility improving performances synthetic nanomaterials. Here, recent advances membrane‐coated are reviewed based on the main biological functions membrane in living cells. An overview introduced understand potential applications. Then, summarized, including physical barrier with selective permeability cellular communication via information transmission reception processes. Finally, perspectives challenges about discussed.

Язык: Английский

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Materials for Immunotherapy

Advanced Materials, Год журнала: 2019, Номер 32(13)

Опубликована: Июнь 28, 2019

Abstract Breakthroughs in materials engineering have accelerated the progress of immunotherapy preclinical studies. The interplay chemistry and has resulted improved loading, targeting, release immunomodulatory agents. An overview that are used to enable or improve success immunotherapies studies is presented, from immunosuppressive proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. organized based their characteristic length scale, whereby enabling feature each technology by structure material. For example, mechanisms which i) nanoscale can targeting infiltration payloads into tissues cells, ii) microscale facilitate cell‐mediated transport serve as artificial antigen‐presenting iii) macroscale form basis microenvironments promote cell reprogramming discussed. As a step toward establishing set design rules future immunotherapies, intrinsically activate suppress immune system reviewed. Finally, brief outlook trajectory these systems how they may be address unsolved challenges cancer, infectious diseases, autoimmunity presented.

Язык: Английский

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Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(31)

Опубликована: Май 28, 2021

Abstract Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one most effective methods for cancer therapy. Nevertheless, single‐mode immunotherapy is still confronted with several critical challenges, such low immune response, tumor infiltration, and complex immunosuppression microenvironment. Recently, combination other therapeutic modalities a powerful strategy to augment outcome in fighting against cancer. In this review, recent research advances chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic microwave thermotherapy are summarized. Critical challenges future direction immunotherapy‐based also discussed.

Язык: Английский

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