Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
58(33), С. 11404 - 11408
Опубликована: Июнь 17, 2019
Abstract
Anti‐adhesion
therapies
interfere
with
the
bacterial
adhesion
to
host
and
thus
avoid
direct
disruption
of
cycles
for
killing,
which
may
alleviate
resistance
development.
Herein,
an
anti‐adhesion
nanomedicine
platform
is
made
by
wrapping
synthetic
polymeric
cores
outer
membranes.
The
resulting
bacterium‐mimicking
nanoparticles
(denoted
“OM‐NPs”)
compete
source
bacteria
binding
host.
“top‐down”
fabrication
OM‐NPs
avoids
identification
adhesins
bypasses
design
agonists
targeting
these
adhesins.
In
this
study,
are
membrane
Helicobacter
pylori
shown
bind
gastric
epithelial
cells
(AGS
cells).
Treatment
AGS
reduces
H.
such
efficacy
dependent
on
OM‐NP
concentration
its
dosing
sequence.
Abstract
Immunotherapy
has
emerged
as
an
effective
strategy
for
the
prevention
and
treatment
of
a
variety
diseases,
including
cancer,
infectious
inflammatory
autoimmune
diseases.
Immunomodulatory
nanosystems
can
readily
improve
therapeutic
effects
simultaneously
overcome
many
obstacles
facing
method,
such
inadequate
immune
stimulation,
off‐target
side
effects,
bioactivity
loss
agents
during
circulation.
In
recent
years,
researchers
have
continuously
developed
nanomaterials
with
new
structures,
properties,
functions.
This
Review
provides
most
advances
nanotechnology
immunostimulation
immunosuppression.
cancer
immunotherapy,
play
essential
role
in
cell
activation
tumor
microenvironment
modulation,
well
combination
other
antitumor
approaches.
encouraging
outcomes
from
using
nanomaterial
vaccines
against
viral
bacterial
infections
been
reported.
addition,
nanoparticles
also
potentiate
immunosuppressive
cells
Finally,
challenges
prospects
applying
to
modulate
immunotherapy
are
discussed.
Nano-Micro Letters,
Год журнала:
2019,
Номер
11(1)
Опубликована: Ноя. 16, 2019
Abstract
Cell
membrane
coating
technology
is
an
approach
to
the
biomimetic
replication
of
cell
properties,
and
active
area
ongoing
research
readily
applicable
nanoscale
biomedicine.
Nanoparticles
(NPs)
coated
with
membranes
offer
opportunity
unite
natural
properties
those
artificial
inner
core
material.
The
NPs
not
only
increase
their
biocompatibility
but
also
achieve
effective
extended
circulation
in
vivo,
allowing
for
execution
targeted
functions.
Although
membrane-coated
clear
advantages,
much
work
remains
before
they
can
be
applied
clinical
practice.
In
this
review,
we
first
provide
a
comprehensive
overview
theory
technology,
followed
by
summary
existing
preparation
characterization
techniques.
Next,
focus
on
functions
applications
various
types.
addition,
collate
model
drugs
used
review
patent
related
from
past
10
years.
Finally,
survey
future
challenges
trends
pertaining
effort
development
technology.
Nano Letters,
Год журнала:
2020,
Номер
20(7), С. 5570 - 5574
Опубликована: Июнь 17, 2020
We
report
cellular
nanosponges
as
an
effective
medical
countermeasure
to
the
SARS-CoV-2
virus.
Two
types
of
are
made
plasma
membranes
derived
from
human
lung
epithelial
type
II
cells
or
macrophages.
These
display
same
protein
receptors,
both
identified
and
unidentified,
required
by
for
entry.
It
is
shown
that,
following
incubation
with
nanosponges,
neutralized
unable
infect
cells.
Crucially,
nanosponge
platform
agnostic
viral
mutations
potentially
species,
well.
As
long
target
virus
remains
host
cell,
will
be
able
neutralize
Abstract
Inflammation
is
ubiquitous
in
the
body,
triggering
desirable
immune
response
to
defend
against
dangerous
signals
or
instigating
undesirable
damage
cells
and
tissues
cause
disease.
Nanomedicine
holds
exciting
potential
modulating
inflammation.
In
particular,
cell
membranes
derived
from
involved
inflammatory
process
may
be
used
coat
nanotherapeutics
for
effective
targeted
delivery
tissues.
Herein,
recent
progress
of
rationally
engineering
membrane‐based
inflammation
therapy
highlighted,
challenges
opportunities
presented
realizing
full
cell‐membrane
coating
targeting
manipulating
microenvironment
are
discussed.
The
design
of
next-generation
nanobiomaterials
requires
precise
engineering
both
physical
properties
the
core
material
and
chemical
material's
surface
to
meet
a
biological
function.
A
bio-inspired
modular
versatile
technology
was
developed
allow
biodegradable
polymeric
nanoparticles
circulate
through
blood
for
extended
periods
time
while
also
acting
as
detoxification
device.
To
mimic
red
cells,
biomimicry
are
combined
enhance
function
nanomaterials
in
vitro
vivo.
anisotropic
shape
membrane
coating
synergize
resist
cellular
uptake
reduce
clearance
from
blood.
This
approach
enhances
nanoparticles,
markedly
improving
survival
mouse
model
sepsis.
membrane-coated
have
enhanced
biodistribution
therapeutic
efficacy.
These
biomimetic
nanodevices
their
derivatives
promise
applications
ranging
agents,
drug
delivery
vehicles,
sensors.
ACS Applied Nano Materials,
Год журнала:
2020,
Номер
3(9), С. 8557 - 8580
Опубликована: Авг. 26, 2020
Coronavirus
disease
2019
(COVID-19)
is
the
worst
pandemic
of
current
millennium.
This
caused
by
highly
contagious
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
which
first
exhibited
human-to-human
transmission
in
December
and
has
infected
millions
people
within
months
across
213
different
countries.
Its
ability
to
be
transmitted
asymptomatic
carriers
put
a
massive
strain
on
currently
available
testing
resources.
Currently,
there
are
no
clinically
proven
therapeutic
methods
that
clearly
inhibit
effects
this
virus,
COVID-19
vaccines
still
development
phase.
Strategies
need
explored
expand
capacities,
develop
effective
therapeutics,
safe
provide
lasting
immunity.
Nanoparticles
(NPs)
have
been
widely
used
many
medical
applications,
such
as
biosensing,
drug
delivery,
imaging,
antimicrobial
treatment.
SARS-CoV-2
an
enveloped
virus
with
particle-like
characteristics
diameter
60–140
nm.
Synthetic
NPs
can
closely
mimic
interact
strongly
its
proteins
due
their
morphological
similarities.
Hence,
NP-based
strategies
for
tackling
immense
potential.
previously
found
tools
against
viruses,
especially
those
from
Coronaviridae
family.
Review
outlines
role
diagnostics,
vaccination
other
two
epidemic
coronaviruses,
2003
(SARS)
2012
Middle
East
(MERS)
virus.
We
also
highlight
nanomaterial-based
approaches
address
human
coronaviruses
(HCoVs);
feline
(FCoV);
avian
infectious
bronchitis
(IBV);
models,
porcine
diarrhea
(PEDV),
reproductive
(PRRSV),
transmissible
gastroenteritis
(TGEV);
viruses
share
similarities
SARS-CoV-2.
combines
salient
principles
previous
antiviral
studies
recent
research
conducted
outline
combat
similar
pandemics
future.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(39)
Опубликована: Авг. 9, 2020
Abstract
Surface
modification
of
nanomaterials
is
essential
for
their
biomedical
applications
owing
to
passive
immune
clearance
and
damage
reticuloendothelial
systems.
Recently,
a
cell
membrane‐coating
technology
has
been
proposed
as
an
ideal
approach
modify
its
facile
functionalized
process
good
biocompatibility
improving
performances
synthetic
nanomaterials.
Here,
recent
advances
membrane‐coated
are
reviewed
based
on
the
main
biological
functions
membrane
in
living
cells.
An
overview
introduced
understand
potential
applications.
Then,
summarized,
including
physical
barrier
with
selective
permeability
cellular
communication
via
information
transmission
reception
processes.
Finally,
perspectives
challenges
about
discussed.
Advanced Materials,
Год журнала:
2019,
Номер
32(13)
Опубликована: Июнь 28, 2019
Abstract
Breakthroughs
in
materials
engineering
have
accelerated
the
progress
of
immunotherapy
preclinical
studies.
The
interplay
chemistry
and
has
resulted
improved
loading,
targeting,
release
immunomodulatory
agents.
An
overview
that
are
used
to
enable
or
improve
success
immunotherapies
studies
is
presented,
from
immunosuppressive
proinflammatory
strategies,
with
particular
emphasis
on
technologies
poised
for
clinical
translation.
organized
based
their
characteristic
length
scale,
whereby
enabling
feature
each
technology
by
structure
material.
For
example,
mechanisms
which
i)
nanoscale
can
targeting
infiltration
payloads
into
tissues
cells,
ii)
microscale
facilitate
cell‐mediated
transport
serve
as
artificial
antigen‐presenting
iii)
macroscale
form
basis
microenvironments
promote
cell
reprogramming
discussed.
As
a
step
toward
establishing
set
design
rules
future
immunotherapies,
intrinsically
activate
suppress
immune
system
reviewed.
Finally,
brief
outlook
trajectory
these
systems
how
they
may
be
address
unsolved
challenges
cancer,
infectious
diseases,
autoimmunity
presented.
Advanced Materials,
Год журнала:
2021,
Номер
33(31)
Опубликована: Май 28, 2021
Abstract
Immunotherapy
that
can
activate
immunity
or
enhance
the
immunogenicity
of
tumors
has
emerged
as
one
most
effective
methods
for
cancer
therapy.
Nevertheless,
single‐mode
immunotherapy
is
still
confronted
with
several
critical
challenges,
such
low
immune
response,
tumor
infiltration,
and
complex
immunosuppression
microenvironment.
Recently,
combination
other
therapeutic
modalities
a
powerful
strategy
to
augment
outcome
in
fighting
against
cancer.
In
this
review,
recent
research
advances
chemotherapy,
phototherapy,
radiotherapy,
sonodynamic
therapy,
metabolic
microwave
thermotherapy
are
summarized.
Critical
challenges
future
direction
immunotherapy‐based
also
discussed.
