International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11306 - 11306
Опубликована: Окт. 20, 2021
Cancer
is
a
condition
caused
by
many
mechanisms
(genetic,
immune,
oxidation,
and
inflammatory).
Anticancer
therapy
aims
to
destroy
or
stop
the
growth
of
cancer
cells.
Resistance
treatment
theleading
cause
inefficiency
current
standard
therapies.
Targeted
therapies
are
most
effective
due
low
number
side
effects
resistance.
Among
small
molecule
natural
compounds,
flavonoids
particular
interest
for
theidentification
new
anticancer
agents.
Chalcones
precursors
all
have
biological
activities.
The
activity
chalcones
ability
these
compounds
act
on
targets.
Natural
chalcones,
such
as
licochalcones,
xanthohumol
(XN),
panduretin
(PA),
loncocarpine,
been
extensively
studied
modulated.
Modification
basic
structure
in
order
obtain
with
superior
cytotoxic
properties
has
performed
modulating
aromatic
residues,
replacing
residues
heterocycles,
obtaining
hybrid
molecules.
A
huge
chalcone
derivatives
diaryl
ether,
sulfonamide,
amine
obtained,
their
presence
being
favorable
activity.
amino
group
aminochalconesis
always
antitumor
This
why
molecules
different
nitrogen
hetercycles
obtained.
From
these,
azoles
(imidazole,
oxazoles,
tetrazoles,
thiazoles,
1,2,3-triazoles,
1,2,4-triazoles)
importance
identification
Chemical Science,
Год журнала:
2020,
Номер
11(9), С. 2494 - 2503
Опубликована: Янв. 1, 2020
Mitochondria-targeted
photosensitizers
with
highly
efficient
singlet
oxygen
generation,
bright
near-infrared
AIE
and
good
two-photon
absorption
are
obtained
through
ingenious
molecular
engineering
for
cancer
cell-selective
photodynamic
therapy.
Chemical Society Reviews,
Год журнала:
2020,
Номер
50(2), С. 945 - 985
Опубликована: Ноя. 23, 2020
Cell
primitive-based
functional
materials
that
combine
the
advantages
of
natural
substances
and
nanotechnology
have
emerged
as
attractive
therapeutic
agents
for
cancer
therapy.
primitives
are
characterized
by
distinctive
biological
functions,
such
long-term
circulation,
tumor
specific
targeting,
immune
modulation
etc.
Moreover,
synthetic
nanomaterials
featuring
unique
physical/chemical
properties
been
widely
used
effective
drug
delivery
vehicles
or
anticancer
to
treat
cancer.
The
combination
these
two
kinds
will
catalyze
generation
innovative
biomaterials
with
multiple
high
biocompatibility
negligible
immunogenicity
precise
In
this
review,
we
summarize
most
recent
advances
in
development
cell
Different
primitives,
including
bacteria,
phages,
cells,
membranes,
other
bioactive
introduced
their
strategies
combining
materials,
especially
nanoparticulate
systems,
construction
function-enhanced
also
summarized.
Furthermore,
foreseeable
challenges
future
perspectives
included
research
direction
field.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Апрель 22, 2021
The
mitochondrion
is
an
important
sub-cellular
organelle
responsible
for
the
cellular
energetic
source
and
processes.
Owing
to
its
unique
sensitivity
heat
reactive
oxygen
species,
appropriate
target
photothermal
photodynamic
treatment
cancer.
However,
targeted
delivery
of
therapeutics
mitochondria
remains
a
great
challenge
due
their
location
in
compartment
complexity
intracellular
environment.
Herein,
we
report
class
mitochondrion-targeted
liposomal
platform
consisting
guanidinium-based
dendritic
peptide
moiety
mimicking
protein
transmembrane
signaling
exert
with
pH
sensitive
charge-reversible
functions
enhance
tumor
accumulation
cell
penetration.
Compared
current
triphenylphosphonium
(TPP)-based
targeting
system,
this
lipopeptide
(DLP)
exhibits
about
3.7-fold
higher
efficacy.
Complete
eradication
demonstrated
mice
bearing
4T1
mammary
tumors
after
combined
therapies
delivered
by
reported
DLP
platform.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11306 - 11306
Опубликована: Окт. 20, 2021
Cancer
is
a
condition
caused
by
many
mechanisms
(genetic,
immune,
oxidation,
and
inflammatory).
Anticancer
therapy
aims
to
destroy
or
stop
the
growth
of
cancer
cells.
Resistance
treatment
theleading
cause
inefficiency
current
standard
therapies.
Targeted
therapies
are
most
effective
due
low
number
side
effects
resistance.
Among
small
molecule
natural
compounds,
flavonoids
particular
interest
for
theidentification
new
anticancer
agents.
Chalcones
precursors
all
have
biological
activities.
The
activity
chalcones
ability
these
compounds
act
on
targets.
Natural
chalcones,
such
as
licochalcones,
xanthohumol
(XN),
panduretin
(PA),
loncocarpine,
been
extensively
studied
modulated.
Modification
basic
structure
in
order
obtain
with
superior
cytotoxic
properties
has
performed
modulating
aromatic
residues,
replacing
residues
heterocycles,
obtaining
hybrid
molecules.
A
huge
chalcone
derivatives
diaryl
ether,
sulfonamide,
amine
obtained,
their
presence
being
favorable
activity.
amino
group
aminochalconesis
always
antitumor
This
why
molecules
different
nitrogen
hetercycles
obtained.
From
these,
azoles
(imidazole,
oxazoles,
tetrazoles,
thiazoles,
1,2,3-triazoles,
1,2,4-triazoles)
importance
identification
