Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Сен. 14, 2020
Abstract
Recently,
three-terminal
synaptic
devices
have
attracted
considerable
attention
owing
to
their
nondestructive
weight-update
behavior,
which
is
attributed
the
completely
separated
terminals
for
reading
and
writing.
However,
structural
limitations
of
these
devices,
such
as
a
low
array
density
complex
line
design,
are
predicted
result
in
processing
speeds
high
energy
consumption
entire
system.
Here,
we
propose
vertical
synapse
featuring
remote
weight
update
via
ion
gel,
also
extendable
crossbar
structure.
This
device
exhibits
excellent
characteristics,
achieved
precise
control
penetration
onto
channel
through
weight-control
terminal.
Especially,
applicability
developed
organic
neuromorphic
computing
demonstrated
using
simple
array.
The
proposed
technology
expected
be
an
important
steppingstone
development
high-performance
high-density
neural
networks.
Advanced Materials,
Год журнала:
2019,
Номер
31(49)
Опубликована: Сен. 24, 2019
As
the
research
on
artificial
intelligence
booms,
there
is
broad
interest
in
brain-inspired
computing
using
novel
neuromorphic
devices.
The
potential
of
various
emerging
materials
and
devices
for
has
attracted
extensive
efforts,
leading
to
a
large
number
publications.
Going
forward,
order
better
emulate
brain's
functions,
its
relevant
fundamentals,
working
mechanisms,
resultant
behaviors
need
be
re-visited,
understood,
connected
electronics.
A
systematic
overview
biological
neural
systems
given,
along
with
their
related
critical
mechanisms.
Recent
progress
reviewed
and,
more
importantly,
existing
challenges
are
highlighted
hopefully
shed
light
future
directions.
Applied Physics Reviews,
Год журнала:
2020,
Номер
7(1)
Опубликована: Фев. 24, 2020
The
rapid
development
of
information
technology
has
led
to
urgent
requirements
for
high
efficiency
and
ultralow
power
consumption.
In
the
past
few
decades,
neuromorphic
computing
drawn
extensive
attention
due
its
promising
capability
in
processing
massive
data
with
extremely
low
Here,
we
offer
a
comprehensive
review
on
emerging
artificial
devices
their
applications.
light
inner
physical
processes,
classify
into
nine
major
categories
discuss
respective
strengths
weaknesses.
We
will
show
that
anion/cation
migration-based
memristive
devices,
phase
change,
spintronic
synapses
have
been
quite
mature
possess
excellent
stability
as
memory
device,
yet
they
still
suffer
from
challenges
weight
updating
linearity
symmetry.
Meanwhile,
recently
developed
electrolyte-gated
synaptic
transistors
demonstrated
outstanding
energy
efficiency,
linearity,
symmetry,
but
scalability
need
be
optimized.
Other
structures,
such
ferroelectric,
metal–insulator
transition
based,
photonic,
purely
electronic
also
limitations
some
aspects,
therefore
leading
further
developing
high-performance
devices.
Additional
efforts
are
demanded
enhance
functionality
neurons
while
maintaining
relatively
cost
area
power,
it
significance
explore
intrinsic
neuronal
stochasticity
optimize
driving
capability,
etc.
Finally,
by
looking
correlations
between
operation
mechanisms,
material
systems,
device
performance,
provide
clues
future
selections,
designs,
integrations
neurons.
Advanced Functional Materials,
Год журнала:
2019,
Номер
29(42)
Опубликована: Авг. 9, 2019
Abstract
Simulating
biological
synapses
with
electronic
devices
is
a
re‐emerging
field
of
research.
It
widely
recognized
as
the
first
step
in
hardware
building
brain‐like
computers
and
artificial
intelligent
systems.
Thus
far,
different
types
have
been
proposed
to
mimic
synaptic
functions.
Among
them,
transistor‐based
advantages
good
stability,
relatively
controllable
testing
parameters,
clear
operation
mechanism,
can
be
constructed
from
variety
materials.
In
addition,
they
perform
concurrent
learning,
which
weight
update
performed
without
interrupting
signal
transmission
process.
Synergistic
control
one
device
also
implemented
synapse,
opens
up
possibility
developing
robust
neuron
networks
significantly
fewer
neural
elements.
These
unique
features
make
them
more
suitable
for
emulating
functions
than
other
devices.
However,
development
still
its
very
early
stages.
Herein,
this
article
presents
review
recent
advances
order
give
guideline
future
implementation
transistors.
The
main
challenges
research
directions
are
presented.
Advanced Materials,
Год журнала:
2018,
Номер
31(3)
Опубликована: Ноя. 28, 2018
Just
as
biological
synapses
provide
basic
functions
for
the
nervous
system,
artificial
synaptic
devices
serve
fundamental
building
blocks
of
neuromorphic
networks;
thus,
developing
novel
is
essential
computing.
By
exploiting
band
alignment
between
2D
inorganic
and
organic
semiconductors,
first
multi-functional
transistor
based
on
a
molybdenum
disulfide
(MoS2
)/perylene-3,4,9,10-tetracarboxylic
dianhydride
(PTCDA)
hybrid
heterojunction,
with
remarkable
short-term
plasticity
(STP)
long-term
(LTP),
reported.
Owing
to
elaborate
design
energy
structure,
both
robust
electrical
optical
modulation
are
achieved
through
carriers
transfer
at
interface
heterostructure,
which
still
challenging
task
this
day.
In
modulation,
inhibition
excitation
can
be
simultaneously
in
same
device
by
gate
voltage
tuning.
Notably,
minimum
3%
maximum
facilitation
500%
obtained
increasing
number,
response
different
frequency
signals
indicates
dynamic
filtering
characteristic.
It
exhibits
flexible
tunability
STP
LTP
weight
changes
up
60,
far
superior
previous
work
modulation.
The
fully
MoS2
/PTCDA
heterojunction
synapse
opens
whole
new
path
urgent
need
computation
devices.
Advanced Materials,
Год журнала:
2019,
Номер
32(15)
Опубликована: Сен. 26, 2019
Flexible
neuromorphic
electronics
that
emulate
biological
neuronal
systems
constitute
a
promising
candidate
for
next-generation
wearable
computing,
soft
robotics,
and
neuroprosthetics.
For
realization,
with
the
achievement
of
simple
synaptic
behaviors
in
single
device,
construction
artificial
synapses
various
functions
sensing
responding
integrated
to
mimic
complicated
sensing,
is
prerequisite.
Artificial
have
learning
ability
can
perceive
react
events
real
world;
these
abilities
expand
applications
toward
health
monitoring
cybernetic
devices
future
Internet
Things.
To
demonstrate
flexible
successfully,
it
essential
develop
nerves
replicating
functionalities
counterparts
satisfying
requirements
constructing
elements
such
as
flexibility,
low
power
consumption,
high-density
integration,
biocompatibility.
Here,
progress
addressed,
from
basic
backgrounds
including
characteristics,
device
structures,
mechanisms
nerves,
Finally,
research
directions
are
suggested
this
emerging
area.
Nano Letters,
Год журнала:
2018,
Номер
18(6), С. 3643 - 3650
Опубликована: Май 4, 2018
Disulfide
bonds
have
been
widely
used
to
develop
reduction-responsive
drug-delivery
systems
(DDS)
for
cancer
therapy.
We
propose
that
disulfide
might
be
also
as
an
oxidation-responsive
linkage
just
like
thioether
bonds,
which
can
oxidized
hydrophilic
sulfoxide
or
sulphone
in
the
presence
of
oxidation
stimuli.
To
test
our
hypothesis,
we
design
three
novel
paclitaxel–citronellol
conjugates
linked
via
different
lengths
disulfide-bond-containing
carbon
chain.
The
prodrugs
self-assemble
into
uniform-size
nanoparticles
with
impressively
high
drug
loading
(>55%).
As
expected,
disulfide-bond-bridged
prodrug
show
redox
dual-responsive
release.
More
interestingly,
position
chain
has
profound
impacts
on
dual
responsiveness,
thereby
affecting
release,
cytotoxicity,
pharmacokinetics,
biodistribution,
and
vivo
antitumor
efficacy
nanoassemblies.
mechanism
is
elucidated,
how
affects
responsiveness
efficiency
nanoassemblies
clarified.
Our
findings
give
new
insight
stimuli
provide
a
good
foundation
development
DDS
Advanced Functional Materials,
Год журнала:
2020,
Номер
31(8)
Опубликована: Ноя. 13, 2020
Abstract
From
Deep
Blue
to
AlphaGo,
artificial
intelligence
and
machine
learning
are
booming,
neural
networks
have
become
the
hot
research
direction.
However,
due
size
limit
of
complementary
metal–oxide–semiconductor
(CMOS)
transistors,
von
Neumann‐based
computing
systems
facing
multiple
challenges
(such
as
memory
walls).
As
number
transistors
required
by
network
increases,
development
based
on
Neumann
computer
is
limited
volume
energy
consumption.
fourth
basic
circuit
element,
memristor
shines
in
field
neuromorphic
computing.
The
new
architecture
widely
considered
a
substitute
for
has
great
potential
deal
with
big
data
era
challenge.
This
article
reviews
existing
materials
structures
memristors,
neurophysiological
simulations
applications
memristor‐based
networks.
feasibility
advancement
implementing
using
memristors
discussed,
difficulties
that
need
be
overcome
at
this
stage
put
forward,
their
prospects
faced
also
discussed.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Март 19, 2021
Abstract
The
challenges
of
developing
neuromorphic
vision
systems
inspired
by
the
human
eye
come
not
only
from
how
to
recreate
flexibility,
sophistication,
and
adaptability
animal
systems,
but
also
do
so
with
computational
efficiency
elegance.
Similar
biological
these
circuits
integrate
functions
image
sensing,
memory
processing
into
device,
process
continuous
analog
brightness
signal
in
real-time.
High-integration,
flexibility
ultra-sensitivity
are
essential
for
practical
artificial
that
attempt
emulate
processing.
Here,
we
present
a
flexible
optoelectronic
sensor
array
1024
pixels
using
combination
carbon
nanotubes
perovskite
quantum
dots
as
active
materials
an
efficient
system.
device
has
extraordinary
sensitivity
light
responsivity
5.1
×
10
7
A/W
specific
detectivity
2
16
Jones,
demonstrates
reinforcement
learning
training
weak
pulse
1
μW/cm
.
Advanced Materials,
Год журнала:
2020,
Номер
32(11)
Опубликована: Янв. 27, 2020
Abstract
Photonic
synapses
combine
sensing
and
processing
in
a
single
device,
so
they
are
promising
candidates
to
emulate
visual
perception
of
biological
retina.
However,
photonic
with
wavelength
selectivity,
which
is
key
property
for
perception,
have
not
been
developed
far.
Herein,
organic
that
selectively
detect
UV
rays
process
various
optical
stimuli
presented.
The
use
carbon
nitride
(C
3
N
4
)
as
an
UV‐responsive
floating‐gate
layer
transistor
geometry.
C
nanodots
dominantly
absorb
light;
this
trait
the
basis
selectivity
these
synapses.
presented
devices
consume
only
18.06
fJ
per
synaptic
event,
comparable
energy
consumption
Furthermore,
situ
modulation
exposure
light
demonstrated
by
integrating
transmittance
modulators.
These
smart
systems
can
be
further
detection
dose‐calculation
determine
how
when
decrease
preventive
health
care.