Multicharged cyclodextrin supramolecular assemblies

Chemical Society Reviews, Год журнала: 2022, Номер 51(11), С. 4786 - 4827

Опубликована: Янв. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Язык: Английский

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Photooxidation-Driven Purely Organic Room-Temperature Phosphorescent Lysosome-Targeted Imaging

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(34), С. 13887 - 13894

Опубликована: Авг. 19, 2021

The construction of host-guest-binding-induced phosphorescent supramolecular assemblies has become one increasingly significant topics in biomaterial research. Herein, we demonstrate that the cucurbit[8]uril host can induce anthracene-conjugated bromophenylpyridinium guest to form a linear assembly, thus facilitating enhancement red fluorescence emission by host-stabilized charge-transfer interactions. When anthryl group is photo-oxidized anthraquinone, obtained nanoconstructs be readily converted into homoternary inclusion complex, accompanied emergence strong green phosphorescence aqueous solution. More intriguingly, dual organelle-targeted imaging abilities have been also distinctively achieved nuclei and lysosomes after undergoing photochemical reaction upon UV irradiation. This photooxidation-driven purely organic room-temperature provides convenient feasible strategy for organelle identification track specific biospecies physiological events living cells.

Язык: Английский

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130 years of cyclodextrin discovery for health, food, agriculture, and the industry: a review

Environmental Chemistry Letters, Год журнала: 2021, Номер 19(3), С. 2581 - 2617

Опубликована: Янв. 13, 2021

Язык: Английский

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Mechanically interlocked polymers based on rotaxanes

Chemical Society Reviews, Год журнала: 2022, Номер 51(16), С. 7046 - 7065

Опубликована: Янв. 1, 2022

The nature of mechanically interlocked molecules (MIMs) has continued to encourage researchers design and construct a variety high-performance materials. Introducing structures into polymers led novel polymeric materials, called (MIPs). Rotaxane-based MIPs are an important class, where the characteristic retains high degree structural freedom mobility their components, such as rotation sliding motions rotaxane units. Therefore, these MIP materials known possess unique set properties, including mechanical robustness, adaptability responsiveness, which endow them with potential applications in many emerging fields, protective intelligent actuators, mechanisorption. In this review, we outline synthetic strategies, structure-property relationships, application explorations various polyrotaxanes, linear polyrotaxane networks, dendrimers.

Язык: Английский

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Emergent behavior in nanoconfined molecular containers

Chem, Год журнала: 2021, Номер 7(4), С. 919 - 947

Опубликована: Март 19, 2021

Язык: Английский

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Color‐Tunable Supramolecular Luminescent Materials

Advanced Materials, Год журнала: 2021, Номер 34(22)

Опубликована: Окт. 22, 2021

Abstract Constructing multicolor photoluminescent materials with tunable properties is an attractive research objective on account of their abundant applications in science and biomedical engineering. By comparison covalent synthesis, supramolecular chemistry has provided a more competitive promising strategy for the production organic regulation photophysical properties. taking advantage dynamic reversible noncovalent bonding interactions, strategies can, not only simplify design fabrication materials, but can also endow them reversibility stimuli responsiveness, making it much easier to adjust superstructures materials. Occasionally, possible introduce emergent into these which are absent precursor compounds, broadening potential applications. In attempt highlight state‐of‐the‐art available construction smart luminescent overview color‐tunable presented this Review, emphasis being placed examples drawn from host–guest complexes, assemblies crystalline The synthesis room‐temperature phosphorescent modulation described. Finally, future directions scientific challenges field emissive discussed.

Язык: Английский

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Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 170, С. 142 - 199

Опубликована: Янв. 11, 2021

Язык: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Год журнала: 2023, Номер 36(21)

Опубликована: Июль 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Язык: Английский

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In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma

Science Advances, Год журнала: 2022, Номер 8(19)

Опубликована: Май 11, 2022

Cell-based drug carriers are mostly prepared in vitro, which may negatively affect the physiological functions of cells, and induce possible immune rejections when applied to different individuals. In addition, immunosuppressive tumor microenvironment limits cell-mediated delivery. Here, we report an vivo strategy construct cell-based nanomedicine carriers, where bacteria-mimetic gold nanoparticles (GNPs) intravenously injected, selectively phagocytosed by phagocytic subsequently self-assemble into sizable intracellular aggregates via host-guest interactions. The minimize exocytosis GNPs from cells activate photothermal property plasmonic coupling effects. Phagocytic carry GNP melanoma tissue inflammatory tropism. Moreover, initial treatment (PTT) induces damage that provides positive feedback recruit more for enhanced targeting efficiency. optimized secondary PTT notably improves antitumor immunotherapy, further strengthened checkpoint blockade.

Язык: Английский

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Hydrogen-bond organized 2D metal–organic microsheets: direct ultralong phosphorescence and color-tunable optical waveguides

Science Bulletin, Год журнала: 2022, Номер 67(20), С. 2076 - 2084

Опубликована: Сен. 26, 2022

Язык: Английский

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