Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

Advanced Materials, Год журнала: 2019, Номер 31(46)

Опубликована: Сен. 30, 2019

Inhibition of protein biosynthesis is a promising strategy to develop new therapeutic modalities for cancers; however, noninvasive precise regulation this cellular event in living systems has been rarely reported. In study, semiconducting polymer nanoblockader (SPNB ) developed that can inhibit intracellular synthesis upon near-infrared (NIR) photoactivation synergize with photodynamic therapy (PDT) metastasis-inhibited cancer therapy. SPNB self-assembled from an amphiphilic which grafted poly(ethylene glycol) conjugated blockader through singlet oxygen (1 O2 cleavable linker. Such designed molecular structure not only enables generation 1 under NIR photoirradiation PDT, but also permits blockaders terminate translation. Thereby, exerts synergistic action afford enhanced efficacy tumor ablation. More importantly, -mediated inhibition precisely and remotely downregulates the expression levels metastasis-related proteins tissues, eventually contributing complete lung metastasis. This study thus proposes photoactivatable protherapeutic design

Язык: Английский

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Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Advanced Materials, Год журнала: 2021, Номер 33(22)

Опубликована: Апрель 26, 2021

Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently accumulate in tumors with NIR fluorescence provide preoperative diagnosis. Most of the are excised under intraoperative navigation, whereafter, some microscopic residual completely ablated by photodynamic photothermal therapies for maximally killing cells tissues. Up 90% survival rate be achieved this synergistic image-guided surgery therapies. Importantly, nanoparticles-mediated photothermal/photodynamic plus programmed death-ligand 1 antibody significantly induce elimination enhancing effect immunotherapy. This strategy basis AIEgen improves cancer mice maximized therapeutic outcomes, holds great promise clinical treatment.

Язык: Английский

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Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy

Advanced Science, Год журнала: 2020, Номер 7(15)

Опубликована: Июнь 18, 2020

Abstract Nanotheranostics, which combines optical multiplexed disease detection with therapeutic monitoring in a single modality, has the potential to propel field of nanomedicine toward genuine personalized medicine. Currently employed mainstream modalities using gold nanoparticles (AuNPs) diagnosis and treatment are limited by lack specificity issues associated systemic toxicity. Light‐mediated nanotheranostics offers relatively non‐invasive alternative for cancer AuNPs specific shapes sizes that absorb near infrared (NIR) light, inducing plasmon resonance enhanced tumor generating localized heat ablation. Over last decade, significant progress been made nanotheranostics, however main biological translational barriers leading new paradigm anti‐cancer stem from molecular complexities an incomplete mechanistic understanding utilization Au‐NPs living systems. This work provides comprehensive overview on biological, physical facing development nanotheranostics. It will also summarise recent advances engineering AuNPs, their unique characteristics and, importantly, tunability achieve desired optical/photothermal properties.

Язык: Английский

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In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple‐Negative Breast Cancer

Advanced Functional Materials, Год журнала: 2020, Номер 30(10)

Опубликована: Янв. 20, 2020

Abstract Hypoxia in the tumor microenvironment is a major hurdle dampening antitumor effect of photodynamic therapy (PDT). Herein, active photosynthetic bacteria ( Synechococcus 7942, Syne ) are utilized for tumor‐targeted photosensitizer delivery and situ photocatalyzed oxygen generation to achieve photosynthesis‐boosted PDT. Photosensitizer‐encapsulated nanoparticles (HSA/ICG) assembled by intermolecular disulfide crosslinking attached surface with amide bonds form biomimetic system (S/HSA/ICG). S/HSA/ICG combined capability theranostic HSA/ICG. capable photoautotrophy exhibit moderate immune stimulation certain role under 660 nm laser irradiation. Upon intravenous injection into tumor‐bearing mice, can effectively accumulate tumors generate continuously irradiation through photosynthesis, which remarkably relieve hypoxia enhance reactive species production, thereby completely eliminating primary tumors. This PDT also reverse immunosuppressive robustly evoke systematic responses, excellent on preventing recurrence metastasis inhibition metastatic triple‐negative breast cancer mouse model. Hence, this bacteria‐based immunogenic offers promising approach eliminate both local

Язык: Английский

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The concept and examples of type-III photosensitizers for cancer photodynamic therapy

Chem, Год журнала: 2021, Номер 8(1), С. 197 - 209

Опубликована: Ноя. 4, 2021

Язык: Английский

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