Immune Checkpoint Blockade Mediated by a Small‐Molecule Nanoinhibitor Targeting the PD‐1/PD‐L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer

Small, Год журнала: 2019, Номер 15(49)

Опубликована: Ноя. 8, 2019

Abstract Targeting programmed cell death protein 1 (PD‐1)/programmed ligand (PD‐L1) immunologic checkpoint blockade with monoclonal antibodies has achieved recent clinical success in antitumor therapy. However, therapeutic exhibit several issues such as limited tumor penetration, immunogenicity, and costly production. Here, Bristol‐Myers Squibb nanoparticles (NPs) are prepared using a reprecipitation method. The NPs have advantages including passive targeting, hydrophilic nontoxic features, 100% drug loading rate. BMS‐202 is small‐molecule inhibitor of the PD‐1/PD‐L1 interaction that developed by BMS. Transfer to 4T1 tumor‐bearing mice results markedly slower growth same degree treatment anti‐PD‐L1 antibody (α‐PD‐L1). Consistently, combination Ce6 or α‐PD‐L1 parallel shows more efficacious antimetastatic effects, accompanied enhanced dendritic maturation infiltration antigen‐specific T cells into tumors. Thus, inhibition rates primary distant tumors reach >90%. In addition, able attack spreading metastatic lung offer immune‐memory protection prevent relapse. These indicate possess effects similar therapies Therefore, this work reveals possibility replacing used immunotherapy for NPs.

Язык: Английский

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Cell primitive-based biomimetic functional materials for enhanced cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 945 - 985

Опубликована: Ноя. 23, 2020

Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.

Язык: Английский

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

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Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(22), С. 4459 - 4474

Опубликована: Янв. 1, 2021

In the presented perspective, synthetic method, characterization, and research progress in tumor therapy based on CMMs have been summarized. Also prospects challenges of utilizing for discussed.

Язык: Английский

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Recent advances in porphyrin-based MOFs for cancer therapy and diagnosis therapy

Coordination Chemistry Reviews, Год журнала: 2021, Номер 439, С. 213945 - 213945

Опубликована: Апрель 24, 2021

Язык: Английский

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