1,8-Naphthalimide-based fluorescent chemosensors: recent advances and perspectives

Journal of Materials Chemistry C, Год журнала: 2020, Номер 8(39), С. 13501 - 13529

Опубликована: Янв. 1, 2020

Application of the classic fluorescent dye 1,8-naphthalimide.

Язык: Английский

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Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2020, Номер 167, С. 89 - 108

Опубликована: Июнь 11, 2020

Язык: Английский

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Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Chemical Reviews, Год журнала: 2024, Номер 124(2), С. 455 - 553

Опубликована: Янв. 4, 2024

In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to connected global Internet due lack soft conformal biosensors. The fundamental challenge lies in fact that electronics and biology are distinct incompatible, as they based on different materials via functioning principles. particular, body is curvilinear, yet typically rigid planar. Recent advances design have generated tremendous opportunities wearable bioelectronics, which may bridge gap, enabling ultimate dream healthcare anyone, anytime, anywhere. We begin with a review historical development healthcare, indicating significant trend healthcare. This followed by focal point discussion about new design, particularly low-dimensional nanomaterials. summarize material types their attributes designing bioelectronic sensors; we also cover synthesis fabrication methods, top-down, bottom-up, combined approaches. Next, discuss energy challenges progress made date. addition front-end devices, describe back-end machine learning algorithms, artificial intelligence, telecommunication, software. Afterward, integration systems been applied various testbeds real-world settings, laboratories preclinical clinical environments. Finally, narrate remaining conjunction our perspectives.

Язык: Английский

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Bioinspired nanotopographical design of drug delivery systems

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(2), С. 139 - 152

Опубликована: Янв. 26, 2023

Effective drug delivery is important in the treatment of various biomedical conditions, ranging from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can help overcome challenges efficient such as poor distribution, inefficient penetration across biological barriers off-target effects. The bioinspired nanotopography carrier surfaces provides a physical cue modulate their interaction with systems. In this Review, we discuss how naturally occurring nanotopographical inspire design biomaterials for delivery. We highlight nanoscale surface modifications carriers fabrication strategies, followed by discussion about biointerfaces regulate functions. Key functionalities include bio-adhesion, barrier remodelling, uptake subcellular trafficking, cellular signalling modulation, antimicrobial interfaces. Finally, provide an outlook on future applications delivery, focus key exciting opportunities bench bedside. Three-dimensional plays role components. This Review discusses nanotopographies that improve muco-adhesion cyto-adhesion, modulation activities platforms.

Язык: Английский

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Magnetic‐Driven Broadband Epsilon‐Near‐Zero Materials at Radio Frequency

Advanced Functional Materials, Год журнала: 2023, Номер 34(2)

Опубликована: Сен. 28, 2023

Abstract Epsilon‐near‐zero (ENZ) materials, exhibiting unique physical characteristics such as near‐zero refraction, have aroused extensive interest and exhibit great potentials in novel applications of perfect absorbers, high‐harmonic generation, nonlinear optical response. Here, for the first time, magnetic‐driven broadband ENZ materials are designed by fabricating polyvinyl alcohol (PVA)/Ni@carbon nanotubes (CNTs) films. Dielectric properties including real permittivity ( ɛ ′), imaginary ″), dielectric loss (tan δ ), impedance Z ) investigated. When Ni@CNTs content reached 30 wt.%, negative transferred to positive at ≈11.5 MHz, epsilon‐near‐zero (| ′| < 1) is realized from ≈9 14 broad bandwidth ≈5 MHz. Theory calculations confirm that delocalized electrons introduced CNTs, which improve carrier mobility achieve low frequency dispersion behavior. Longer interfacial polarization electric fields between PVA CNTs also demonstrated theory calculations, enhancing response offset Ni@CNTs. These two mechanisms result radio frequency. This film exhibits excellent magnetic actuation ability under field, broadening magnetically actuated robots with absorption, biomimetic aircrafts shielding ability, photodetectors, etc.

Язык: Английский

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A 3D biomimetic optoelectronic scaffold repairs cranial defects

Science Advances, Год журнала: 2023, Номер 9(7)

Опубликована: Фев. 15, 2023

Bone fractures and defects pose serious health-related issues on patients. For clinical therapeutics, synthetic scaffolds have been actively explored to promote critical-sized bone regeneration, electrical stimulations are recognized as an effective auxiliary facilitate the process. Here, we develop a three-dimensional (3D) biomimetic scaffold integrated with thin-film silicon (Si)-based microstructures. This Si-based hybrid not only provides 3D hierarchical structure for guiding cell growth but also regulates behaviors via photo-induced signals. Remotely controlled by infrared illumination, these Si structures electrically modulate membrane potentials intracellular calcium dynamics of stem cells potentiate proliferation differentiation. In rodent model, Si-integrated demonstrates improved osteogenesis under optical stimulations. Such wirelessly powered optoelectronic eliminates tethered implants fully degrades in biological environment. The combines topographical stimuli modulations, offering broad potential biomedicine.

Язык: Английский

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Nano-hydroxyapatite (nHAp) scaffolds for bone regeneration: Preparation, characterization and biological applications

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105601 - 105601

Опубликована: Март 18, 2024

Язык: Английский

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Interfacing with the Brain: How Nanotechnology Can Contribute

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Interfacing artificial devices with the human brain is central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along technology. Mechanical levers cable winches were used to move parts during mechanical age. Sophisticated electronic wiring remote control arisen age, ultimately leading plug-and-play computer interfaces. Nonetheless, brains so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, most technology mechanically and/or electrically engineered, whereas a living, dynamic entity. As result, worlds difficult interface one another. Nanotechnology, which encompasses engineered solid-state objects integrated circuits, excels at small length scales single few hundred nanometers and, thus, matches sizes biomolecules, biomolecular assemblies, cells. Consequently, we envision nanomaterials nanotools as opportunities in alternative ways. Here, review existing literature on use nanotechnology look forward discussing perspectives limitations based authors' expertise across range complementary disciplines─from neuroscience, engineering, physics, chemistry biology medicine, science mathematics, social jurisprudence. We focus but also include information from related fields when useful complementary.

Язык: Английский

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Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses

Biomaterials, Год журнала: 2025, Номер unknown, С. 123136 - 123136

Опубликована: Янв. 1, 2025

Язык: Английский

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Cellular and Subcellular Contact Guidance on Microfabricated Substrates

Frontiers in Bioengineering and Biotechnology, Год журнала: 2020, Номер 8

Опубликована: Окт. 22, 2020

Topography of the extracellular environment is now recognized as a major determinant cell behavior and function. The study cell-topography interaction, named contact guidance, has greatly benefited from development micro nano-fabrication techniques, allowing emergence increasingly diverse elaborate engineered platforms. purpose this review to provide comprehensive view process guidance cellular subcellular scales. We first classify illustrate large diversity topographies reported in literature by focusing on generic responses topographical cues. Subsequently, complementary fashion, we adopt opposite approach highlight type-specific classically used (arrays pillars or grooves). Finally, discuss recent advances key molecular structures involved sensing. Throughout review, focus particularly neuronal cells, whose unique morphology have inspired body studies field sensing revealed fascinating mechanisms. conclude using current understanding interactions at different scales springboard for identifying future challenges guidance.

Язык: Английский

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