Semiconductor-based
biointerfaces
are
typically
established
either
on
the
surface
of
plasma
membrane
or
within
cytoplasm.
In
Gram-negative
bacteria,
periplasmic
space,
characterized
by
its
confinement
and
presence
numerous
enzymes
peptidoglycans,
offers
additional
opportunities
for
biomineralization,
allowing
nongenetic
modulation
interfaces.
We
demonstrate
semiconductor
nanocluster
precipitation
containing
single-
multiple-metal
elements
periplasm,
as
observed
through
various
electron-
x-ray-based
imaging
techniques.
The
semiconductors
metastable
display
defect-dominant
fluorescent
properties.
Unexpectedly,
defect-rich
(i.e.,
low-grade)
nanoclusters
produced
in
situ
can
still
increase
adenosine
triphosphate
levels
malate
production
when
coupled
with
photosensitization.
expand
sustainability
biohybrid
system
to
include
reducing
heavy
metals
at
primary
level,
building
living
bioreactors
secondary
creating
semi-artificial
photosynthesis
tertiary
level.
biomineralization-enabled
biohybrids
have
potential
serve
defect-tolerant
platforms
diverse
sustainable
applications.
Chemical Reviews,
Год журнала:
2024,
Номер
124(2), С. 455 - 553
Опубликована: Янв. 4, 2024
In
the
era
of
Internet-of-things,
many
things
can
stay
connected;
however,
biological
systems,
including
those
necessary
for
human
health,
remain
unable
to
connected
global
Internet
due
lack
soft
conformal
biosensors.
The
fundamental
challenge
lies
in
fact
that
electronics
and
biology
are
distinct
incompatible,
as
they
based
on
different
materials
via
functioning
principles.
particular,
body
is
curvilinear,
yet
typically
rigid
planar.
Recent
advances
design
have
generated
tremendous
opportunities
wearable
bioelectronics,
which
may
bridge
gap,
enabling
ultimate
dream
healthcare
anyone,
anytime,
anywhere.
We
begin
with
a
review
historical
development
healthcare,
indicating
significant
trend
healthcare.
This
followed
by
focal
point
discussion
about
new
design,
particularly
low-dimensional
nanomaterials.
summarize
material
types
their
attributes
designing
bioelectronic
sensors;
we
also
cover
synthesis
fabrication
methods,
top-down,
bottom-up,
combined
approaches.
Next,
discuss
energy
challenges
progress
made
date.
addition
front-end
devices,
describe
back-end
machine
learning
algorithms,
artificial
intelligence,
telecommunication,
software.
Afterward,
integration
systems
been
applied
various
testbeds
real-world
settings,
laboratories
preclinical
clinical
environments.
Finally,
narrate
remaining
conjunction
our
perspectives.
Nature Reviews Bioengineering,
Год журнала:
2023,
Номер
1(2), С. 139 - 152
Опубликована: Янв. 26, 2023
Effective
drug
delivery
is
important
in
the
treatment
of
various
biomedical
conditions,
ranging
from
autoimmune
disorders
to
cancer
and
bacterial
infections.
Nanostructured
systems
can
help
overcome
challenges
efficient
such
as
poor
distribution,
inefficient
penetration
across
biological
barriers
off-target
effects.
The
bioinspired
nanotopography
carrier
surfaces
provides
a
physical
cue
modulate
their
interaction
with
systems.
In
this
Review,
we
discuss
how
naturally
occurring
nanotopographical
inspire
design
biomaterials
for
delivery.
We
highlight
nanoscale
surface
modifications
carriers
fabrication
strategies,
followed
by
discussion
about
biointerfaces
regulate
functions.
Key
functionalities
include
bio-adhesion,
barrier
remodelling,
uptake
subcellular
trafficking,
cellular
signalling
modulation,
antimicrobial
interfaces.
Finally,
provide
an
outlook
on
future
applications
delivery,
focus
key
exciting
opportunities
bench
bedside.
Three-dimensional
plays
role
components.
This
Review
discusses
nanotopographies
that
improve
muco-adhesion
cyto-adhesion,
modulation
activities
platforms.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 28, 2023
Abstract
Epsilon‐near‐zero
(ENZ)
materials,
exhibiting
unique
physical
characteristics
such
as
near‐zero
refraction,
have
aroused
extensive
interest
and
exhibit
great
potentials
in
novel
applications
of
perfect
absorbers,
high‐harmonic
generation,
nonlinear
optical
response.
Here,
for
the
first
time,
magnetic‐driven
broadband
ENZ
materials
are
designed
by
fabricating
polyvinyl
alcohol
(PVA)/Ni@carbon
nanotubes
(CNTs)
films.
Dielectric
properties
including
real
permittivity
(
ɛ
′),
imaginary
″),
dielectric
loss
(tan
δ
),
impedance
Z
)
investigated.
When
Ni@CNTs
content
reached
30
wt.%,
negative
transferred
to
positive
at
≈11.5
MHz,
epsilon‐near‐zero
(|
′|
<
1)
is
realized
from
≈9
14
broad
bandwidth
≈5
MHz.
Theory
calculations
confirm
that
delocalized
electrons
introduced
CNTs,
which
improve
carrier
mobility
achieve
low
frequency
dispersion
behavior.
Longer
interfacial
polarization
electric
fields
between
PVA
CNTs
also
demonstrated
theory
calculations,
enhancing
response
offset
Ni@CNTs.
These
two
mechanisms
result
radio
frequency.
This
film
exhibits
excellent
magnetic
actuation
ability
under
field,
broadening
magnetically
actuated
robots
with
absorption,
biomimetic
aircrafts
shielding
ability,
photodetectors,
etc.
Bone
fractures
and
defects
pose
serious
health-related
issues
on
patients.
For
clinical
therapeutics,
synthetic
scaffolds
have
been
actively
explored
to
promote
critical-sized
bone
regeneration,
electrical
stimulations
are
recognized
as
an
effective
auxiliary
facilitate
the
process.
Here,
we
develop
a
three-dimensional
(3D)
biomimetic
scaffold
integrated
with
thin-film
silicon
(Si)-based
microstructures.
This
Si-based
hybrid
not
only
provides
3D
hierarchical
structure
for
guiding
cell
growth
but
also
regulates
behaviors
via
photo-induced
signals.
Remotely
controlled
by
infrared
illumination,
these
Si
structures
electrically
modulate
membrane
potentials
intracellular
calcium
dynamics
of
stem
cells
potentiate
proliferation
differentiation.
In
rodent
model,
Si-integrated
demonstrates
improved
osteogenesis
under
optical
stimulations.
Such
wirelessly
powered
optoelectronic
eliminates
tethered
implants
fully
degrades
in
biological
environment.
The
combines
topographical
stimuli
modulations,
offering
broad
potential
biomedicine.
Interfacing
artificial
devices
with
the
human
brain
is
central
goal
of
neurotechnology.
Yet,
our
imaginations
are
often
limited
by
currently
available
paradigms
and
technologies.
Suggestions
for
brain-machine
interfaces
have
changed
over
time,
along
technology.
Mechanical
levers
cable
winches
were
used
to
move
parts
during
mechanical
age.
Sophisticated
electronic
wiring
remote
control
arisen
age,
ultimately
leading
plug-and-play
computer
interfaces.
Nonetheless,
brains
so
complex
that
these
visions,
until
recently,
largely
remained
unreachable
dreams.
The
general
problem,
thus
far,
most
technology
mechanically
and/or
electrically
engineered,
whereas
a
living,
dynamic
entity.
As
result,
worlds
difficult
interface
one
another.
Nanotechnology,
which
encompasses
engineered
solid-state
objects
integrated
circuits,
excels
at
small
length
scales
single
few
hundred
nanometers
and,
thus,
matches
sizes
biomolecules,
biomolecular
assemblies,
cells.
Consequently,
we
envision
nanomaterials
nanotools
as
opportunities
in
alternative
ways.
Here,
review
existing
literature
on
use
nanotechnology
look
forward
discussing
perspectives
limitations
based
authors'
expertise
across
range
complementary
disciplines─from
neuroscience,
engineering,
physics,
chemistry
biology
medicine,
science
mathematics,
social
jurisprudence.
We
focus
but
also
include
information
from
related
fields
when
useful
complementary.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2020,
Номер
8
Опубликована: Окт. 22, 2020
Topography
of
the
extracellular
environment
is
now
recognized
as
a
major
determinant
cell
behavior
and
function.
The
study
cell-topography
interaction,
named
contact
guidance,
has
greatly
benefited
from
development
micro
nano-fabrication
techniques,
allowing
emergence
increasingly
diverse
elaborate
engineered
platforms.
purpose
this
review
to
provide
comprehensive
view
process
guidance
cellular
subcellular
scales.
We
first
classify
illustrate
large
diversity
topographies
reported
in
literature
by
focusing
on
generic
responses
topographical
cues.
Subsequently,
complementary
fashion,
we
adopt
opposite
approach
highlight
type-specific
classically
used
(arrays
pillars
or
grooves).
Finally,
discuss
recent
advances
key
molecular
structures
involved
sensing.
Throughout
review,
focus
particularly
neuronal
cells,
whose
unique
morphology
have
inspired
body
studies
field
sensing
revealed
fascinating
mechanisms.
conclude
using
current
understanding
interactions
at
different
scales
springboard
for
identifying
future
challenges
guidance.