Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 182, С. 114107 - 114107
Опубликована: Янв. 4, 2022
Язык: Английский
Nature reviews. Cancer, Год журнала: 2022, Номер 22(7), С. 381 - 396
Опубликована: Март 25, 2022
Язык: Английский
Процитировано
1417
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 22, 2023
Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.
Язык: Английский
Процитировано
766
Nanoscale Research Letters, Год журнала: 2021, Номер 16(1)
Опубликована: Дек. 1, 2021
Abstract Cancer is one of the leading causes death and morbidity with a complex pathophysiology. Traditional cancer therapies include chemotherapy, radiation therapy, targeted immunotherapy. However, limitations such as lack specificity, cytotoxicity, multi-drug resistance pose substantial challenge for favorable treatment. The advent nanotechnology has revolutionized arena diagnosis Nanoparticles (1–100 nm) can be used to treat due their specific advantages biocompatibility, reduced toxicity, more excellent stability, enhanced permeability retention effect, precise targeting. are classified into several main categories. nanoparticle drug delivery system particular utilizes tumor environment characteristics. not only solve conventional treatment but also overcome multidrug resistance. Additionally, new mechanisms unraveled studied, nanoparticles being investigated vigorously. Various therapeutic implications nanoformulations have created brand perspectives most research limited in vivo vitro studies, number approved nanodrugs much amplified over years. This review discusses numerous types nanoparticles, targeting mechanisms, nanotherapeutics oncological Further, we summarize current perspective, advantages, challenges clinical translation.
Язык: Английский
Процитировано
668
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Язык: Английский
Процитировано
598
Theranostics, Год журнала: 2021, Номер 11(11), С. 5365 - 5386
Опубликована: Янв. 1, 2021
Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend on infiltration T cells capable recognizing and killing cells. ICIs are not effective in "cold tumors", which characterized lack T-cell infiltration. To realize full potential immunotherapy solve this obstacle, it is essential to understand drivers into tumors. We present a critical review our understanding mechanisms underlying including impaired priming deficient homing beds. "Hot tumors" with significant associated better ICI efficacy. In review, we summarize multiple strategies that promote transformation "hot discuss these lead increased Finally, application nanomaterials provide an outlook future emerging field. The combination nanomedicines enhances cross-presentation antigens promotes A deeper opens new possibilities for development cell-based therapies improve effectiveness.
Язык: Английский
Процитировано
531
Nano-Micro Letters, Год журнала: 2021, Номер 13(1)
Опубликована: Июль 9, 2021
Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.
Язык: Английский
Процитировано
435
Journal of Hematology & Oncology, Год журнала: 2021, Номер 14(1)
Опубликована: Сен. 27, 2021
Abstract Immunotherapies such as immune checkpoint blockade (ICB) and adoptive cell therapy (ACT) have revolutionized cancer treatment, especially in patients whose disease was otherwise considered incurable. However, primary secondary resistance to single agent immunotherapy often results treatment failure, only a minority of experience long-term benefits. This review article will discuss the relationship between response mechanisms immunotherapy. It also provide comprehensive on latest clinical status combination therapies (e.g., with chemotherapy, radiation targeted therapy), approved by US Food Drug Administration. an overview targeting cytokines other soluble immunoregulatory factors, ACT, virotherapy, innate modifiers vaccines, well that exploit alternative targets therapeutic modalities. Finally, this include stimulating insights from 2020 China Immuno-Oncology Workshop co-organized Chinese American Hematologist Oncologist Network (CAHON), National Medical Product Administration (NMPA) Tsinghua University School Medicine.
Язык: Английский
Процитировано
433
Trends in Molecular Medicine, Год журнала: 2021, Номер 27(9), С. 856 - 867
Опубликована: Июль 23, 2021
Язык: Английский
Процитировано
221
Cancer Communications, Год журнала: 2022, Номер 42(11), С. 1112 - 1140
Опубликована: Сен. 7, 2022
Abstract Multidimensional analyses have demonstrated the presence of a unique tumor microenvironment (TME) in liver cancer. Tumor‐associated macrophages (TAMs) are among most abundant immune cells infiltrating TME and present at all stages cancer progression, targeting TAMs has become one favored immunotherapy strategies. In addition, distinct origins. At early stage cancer, can provide niche for maintenance stem cells. contrast, (CSCs) or poorly differentiated key factors modulating macrophage activation. review, we first propose origin connection between precursor Macrophages undergo dynamic phenotypic transition during carcinogenesis. this course such transition, it is critical to determine appropriate timing therapy block specific markers suppress pro‐tumoral TAMs. The review provides more detailed discussion trends surface than previous reviews. Complex crosstalk occurs play indispensable roles angiogenesis, autophagy due their heterogeneity robust plasticity. interact with other by directing cell‐to‐cell contact secreting various effector molecules. Similarly, combined drive recruitment polarization. Despite latest achievements advancements treatment strategies following studies, comprehensive discussions on communication currently lacking. discussed interactions (from cell maturation), therapeutic (including chimeric antigen receptor macrophages), clinical trials hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (iCCA) rationale further investigation as potential target treating patients
Язык: Английский
Процитировано
215
Molecular Therapy, Год журнала: 2022, Номер 30(10), С. 3133 - 3154
Опубликована: Апрель 9, 2022
Exosomes have a crucial role in intercellular communication and mediate interactions between tumor cells tumor-associated macrophages (TAMs). Exosome-encapsulated non-coding RNAs (ncRNAs) are involved various physiological processes. Tumor-derived exosomal ncRNAs induce M2 macrophage polarization through signaling pathway activation, signal transduction, transcriptional post-transcriptional regulation. Conversely, TAM-derived promote proliferation, metastasis, angiogenesis, chemoresistance, immunosuppression. MicroRNAs gene silencing by directly targeting mRNAs, whereas lncRNAs circRNAs act as miRNA sponges to indirectly regulate protein expressions. The of tumor-host is ubiquitous. Current research increasingly focused on the microenvironment. On basis "cancer-immunity cycle" hypothesis, we discuss effects immune T cell exhaustion, overexpression programmed death ligands, create immunosuppressive Furthermore, potential applications prospects clinical biomarkers drug delivery systems. 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Язык: Английский
Процитировано
199