Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5604 - 5640

Опубликована: Янв. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Язык: Английский

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Nanozyme‐Based Stretchable Hydrogel of Low Hysteresis with Antibacterial and Antioxidant Dual Functions for Closely Fitting and Wound Healing in Movable Parts

Advanced Functional Materials, Год журнала: 2021, Номер 32(13)

Опубликована: Дек. 7, 2021

Abstract Wound healing in movable parts including joints and neck remains a critical challenge due to frequent motions poor flexibility of dressing which may lead mismatching mechanical properties fitting between dressings wounds, thus increasing the risk bacterial infection inflammation. Herein, through copolymerization N ‐isopropylacrylamide, acrylamide, acryloyl Pluronic 127 (PF127‐DA), functionalization by molybdenum disulfide‐polydopamine nanozyme (MP), new type stretchable, adhesive, low hysteretic MP composite hydrogel (MPH) with antibacterial antioxidant dual functions for closely wound is designed. The excellent (stretching about 616%, hysteresis 0.17) adhesiveness (about 3.25 kPa) MPH make it fast match parts, close fit resisting invasion, effective avoid secondary fixation. Furthermore, derived from photothermal intrinsic enzyme‐like activity can eliminate (exposing 808 nm irradiation, killing ratios Staphylococcus aureus Escherichia coli are 99.1% 93.9%), reduce oxidative stress, improve microenvironment, promote healing.

Язык: Английский

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Recent Progress of Conductive Hydrogel Fibers for Flexible Electronics: Fabrications, Applications, and Perspectives

Advanced Functional Materials, Год журнала: 2023, Номер 33(17)

Опубликована: Янв. 31, 2023

Abstract Flexible conductive materials with intrinsic structural characteristics are currently in the spotlight of both fundamental science and advanced technological applications due to their functional preponderances such as remarkable conductivity, excellent mechanical properties, tunable physical chemical so on. Typically, hydrogel fibers (CHFs) promising candidates owing unique including light weight, high length‐to‐diameter ratio, deformability, Herein, a comprehensive overview cutting‐edge advances CHFs involving architectural features, function characteristics, fabrication strategies, applications, perspectives flexible electronics provided. The design principles strategies systematically introduced discontinuous (the capillary polymerization draw spinning) continuous wet spinning, microfluidic 3D printing, electrospinning). In addition, potential crucially emphasized energy harvesting devices, storage smart sensors, biomedical electronics. This review concludes perspective on challenges opportunities attractive CHFs, allowing for better understanding fundamentals development materials.

Язык: Английский

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Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Advanced Functional Materials, Год журнала: 2022, Номер 32(32)

Опубликована: Май 31, 2022

Abstract The human health is still threatened by refractory keratitis and diabetic foot ulcers caused bacterial infections, hypoxia, chronic inflammation, so that patients are exposed to the risk of amputation, vision loss, even death. Herein, an oxygen‐producing double‐layered hydrogel developed can visualize infections supply oxygen enhance antimicrobial photodynamic therapy (PDT) inflammation alleviation for wounds healing. inner layer (containing oxidized sodium alginate/carboxymethyl chitosan [CMCS] via Schiff‐base) incorporated with a metal–organic framework (PCN‐224) pH indicator (bromothymol blue). outer agarose CMCS) loads photosynthetic cyanobacteria continuously generate relieve hypoxia tissue PDT efficiency. Meanwhile, some unique advantages reflected continuous under natural light, such as cell migration acceleration, relief, promotion skin capillary formation, wound recovery. Therefore, self‐oxygenated offers tremendous benefits in synergistic treatment anaerobe from timely infection monitoring repair.

Язык: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

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Polymer-based responsive structural color materials

Progress in Materials Science, Год журнала: 2023, Номер 135, С. 101091 - 101091

Опубликована: Фев. 10, 2023

Язык: Английский

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Biocompatible Material‐Based Flexible Biosensors: From Materials Design to Wearable/Implantable Devices and Integrated Sensing Systems

Small, Год журнала: 2023, Номер 19(27)

Опубликована: Апрель 3, 2023

Abstract Human beings have a greater need to pursue life and manage personal or family health in the context of rapid growth artificial intelligence, big data, Internet Things, 5G/6G technologies. The application micro biosensing devices is crucial connecting technology personalized medicine. Here, progress current status from biocompatible inorganic materials organic composites are reviewed material‐to‐device processing described. Next, operating principles pressure, chemical, optical, temperature sensors dissected these flexible biosensors wearable/implantable discussed. Different systems acting vivo vitro, including signal communication energy supply then illustrated. potential in‐sensor computing for applications sensing also Finally, some essential needs commercial translation highlighted future opportunities considered.

Язык: Английский

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Tunable metasurfaces via the humidity responsive swelling of single-step imprinted polyvinyl alcohol nanostructures

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Окт. 21, 2022

Abstract The application of hydrogels in nanophotonics has been restricted due to their low fabrication feasibility and refractive index. Nevertheless, elasticity strength are attractive properties for use flexible, wearable-devices, swelling characteristics response the relative humidity highlight potential tunable nanophotonics. We investigate nanostructured polyvinyl alcohol (PVA) using a one-step nanoimprinting technique erasable optical security metasurfaces with multiplexed structural coloration metaholography. resolution PVA reaches sub-100 nm, aspect ratios approaching 10. In changes humidity, nanostructures swell by up ~35.5%, providing precise wavefront manipulation visible light. Here, we demonstrate various highly-secure encryption display, hide, or destroy encrypted information based on both irreversibly reversibly.

Язык: Английский

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Construction and function of robust and moist bilayer chitosan-based hydrogel wound dressing

Materials & Design, Год журнала: 2023, Номер 226, С. 111604 - 111604

Опубликована: Янв. 6, 2023

The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan polyacrylamide double network (C-A) chosen a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer designed to cover surface, interfacial reaction happens link two layers tightly for achieving function synergy. In this double-layer (DH) dressing, surface P-A with strong locking ability could keep moist long time, high strength toughness make maintain integrity under large deformation stress strengthen protection, C-A modest adhesion ensures fit skin, synergistic swelling guarantee fast absorption exudate. Moreover, in vitro vivo tests, DH exhibits excellent antibacterial cytocompatibility, it significantly accelerate tissue regeneration closure than commercial hydrocolloid dressings. general, easy prepare shows superior comprehensive performance, revealing great potential use independently applied dressing.

Язык: Английский

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3D-printed fish gelatin scaffolds for cartilage tissue engineering

Bioactive Materials, Год журнала: 2023, Номер 26, С. 77 - 87

Опубликована: Фев. 24, 2023

Knee osteoarthritis is a chronic disease caused by the deterioration of knee joint due to various factors such as aging, trauma, and obesity, nonrenewable nature injured cartilage makes treatment challenging. Here, we present three-dimensional (3D) printed porous multilayer scaffold based on cold-water fish skin gelatin for osteoarticular regeneration. To make scaffold, was combined with sodium alginate increase viscosity, printability, mechanical strength, hybrid hydrogel according pre-designed specific structure using 3D printing technology. Then, scaffolds underwent double-crosslinking process enhance their strength even further. These mimic original network in way that allows chondrocytes adhere, proliferate, communicate each other, transport nutrients, prevent further damage joint. More importantly, found were nonimmunogenic, nontoxic, biodegradable. We also implanted into defective rat 12 weeks achieved satisfactory repair results this animal model. Thus, may have broad application potential regenerative medicine.

Язык: Английский

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