Theranostics,
Год журнала:
2022,
Номер
12(15), С. 6576 - 6594
Опубликована: Янв. 1, 2022
Bone
and
soft
tissue
tumors
are
complex
mesenchymal
neoplasms
that
seriously
endanger
human
health.
Over
the
past
decade,
relationship
between
microorganisms
health
diseases
is
getting
more
attention.
The
extracellular
vesicles
derived
from
bacteria
have
been
shown
to
regulate
bacterial-host
cell
communication
by
transferring
their
contents,
including
nucleic
acids,
proteins,
metabolites,
lipopolysaccharides,
peptidoglycans.
Bacteria
(BEVs)
promising
lipid-bilayer
nanocarriers
for
treatment
of
many
due
low
toxicity,
drug
loading
capacity,
ease
modification
industrialization.
Specially,
BEVs-based
cancer
therapy
has
attracted
much
attention
because
ability
effectively
stimulate
immune
responses.
In
this
review,
we
provide
an
overview
biogenesis,
composition,
isolation,
classification,
internalization
BEVs.
We
then
comprehensively
summarize
sources
BEVs
in
BEVs-related
strategies.
further
highlight
great
potential
bone
tumors.
Finally,
conclude
major
advantages
challenges
therapy.
believe
comprehensive
understanding
field
will
generate
innovative
solutions
achieve
clinical
applications.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Bioactive Materials,
Год журнала:
2021,
Номер
14, С. 76 - 85
Опубликована: Дек. 18, 2021
An
increased
demand
for
iron
is
a
hallmark
of
cancer
cells
and
thought
necessary
to
promote
high
cell
proliferation,
tumor
progression
metastasis.
This
makes
metabolism
an
attractive
therapeutic
target.
Unfortunately,
current
iron-based
strategies
often
lack
effectiveness
can
elicit
off-target
toxicities.
We
report
here
dual-therapeutic
prodrug,
DOXjade,
that
allows
chelation
chemo-photothermal
therapy.
prodrug
takes
advantage
the
clinically
approved
chelator
deferasirox
(ExJade®)
topoisomerase
2
inhibitor,
doxorubicin
(DOX).
Loading
DOXjade
onto
ultrathin
2D
Ti3C2
MXene
nanosheets
produces
construct,
Ti3C2-PVP@DOXjade,
chemotherapeutic
functions
be
photo-activated
at
sites,
while
potentiating
robust
photothermal
effect
with
conversion
efficiencies
up
40%.
Antitumor
mechanistic
investigations
reveal
upon
activation,
Ti3C2-PVP@DOXjade
serves
apoptotic
death
downregulate
depletion-induced
transferrin
receptor
(TfR).
A
pH-responsive
chelation/photothermal/chemotherapy
antitumor
was
achieved
both
in
vitro
vivo.
The
results
this
study
highlight
what
may
constitute
promising
chelation-based
phototherapeutic
approach
Advanced Materials,
Год журнала:
2022,
Номер
34(33)
Опубликована: Июнь 27, 2022
Lung
metastasis
is
challenging
in
patients
with
triple-negative
breast
cancer
(TNBC).
Surgery
always
not
available
due
to
the
dissemination
of
metastatic
foci
and
most
drugs
are
powerless
because
poor
retention
at
sites.
TNBC
cells
generate
an
inflamed
microenvironment
overexpress
adhesive
molecules
promote
invasion
colonization.
Herein,
"walking
dead"
developed
through
conjugating
anti-PD-1
(programmed
death
protein
1
inhibitor)
doxorubicin
(DOX)-loaded
liposomes
onto
cell
corpses
for
temporal
chemo-immunotherapy
against
lung
metastasis.
The
walking
dead
maintain
plenary
tumor
antigens
conduct
vaccination
effects.
Anti-PD-1
antibodies
conjugated
via
reduction-activated
linker,
DOX-loaded
attached
by
maleimide-thiol
coupling.
This
anchor
strategy
enables
rapid
release
upon
reduction
conditions
while
long-lasting
DOX
improve
pulmonary
accumulation
local
drugs,
reprogram
damage-associated
molecular
patterns
(DAMPs)
PD-1
blockade,
prolong
overall
survival
4T1
EMT6-bearing
mice.
Taking
advantage
preferred
delivery
chemotherapeutics
checkpoint
inhibitors,
this
study
suggests
alternative
treatment
option
augment
efficacy
Nano Letters,
Год журнала:
2022,
Номер
22(11), С. 4491 - 4500
Опубликована: Май 23, 2022
Cancer
vaccines
are
emerging
as
an
attractive
modality
for
tumor
immunotherapy.
However,
their
practical
application
is
seriously
impeded
by
the
complex
fabrication
and
unsatisfactory
outcomes.
Herein,
we
construct
bacterial
outer
membrane
vesicles
(OMVs)-based
in
situ
cancer
vaccine
with
phytochemical
features
photodynamic
effects-promoted
By
simply
fusing
thylakoid
membranes
OMVs,
bacteria-plant
hybrid
(BPNs)
prepared.
After
systemic
administration,
BPNs
can
target
tissues
stimulate
activation
of
immune
cells,
including
dendritic
cells
(DCs).
The
effects
derived
from
lead
to
disruption
local
tumors
then
release
tumor-associated
antigens
that
effectively
presented
DCs,
inducing
remarkable
tumor-specific
CD8+T
cell
responses.
Moreover,
efficiently
ameliorate
immunosuppressive
microenvironment
further
boost
Therefore,
both
development
metastasis
be
prevented.
This
work
provides
a
novel
idea
developing
versatile
membrane-based
system
highly
efficient
treatment.
Theranostics,
Год журнала:
2022,
Номер
12(15), С. 6576 - 6594
Опубликована: Янв. 1, 2022
Bone
and
soft
tissue
tumors
are
complex
mesenchymal
neoplasms
that
seriously
endanger
human
health.
Over
the
past
decade,
relationship
between
microorganisms
health
diseases
is
getting
more
attention.
The
extracellular
vesicles
derived
from
bacteria
have
been
shown
to
regulate
bacterial-host
cell
communication
by
transferring
their
contents,
including
nucleic
acids,
proteins,
metabolites,
lipopolysaccharides,
peptidoglycans.
Bacteria
(BEVs)
promising
lipid-bilayer
nanocarriers
for
treatment
of
many
due
low
toxicity,
drug
loading
capacity,
ease
modification
industrialization.
Specially,
BEVs-based
cancer
therapy
has
attracted
much
attention
because
ability
effectively
stimulate
immune
responses.
In
this
review,
we
provide
an
overview
biogenesis,
composition,
isolation,
classification,
internalization
BEVs.
We
then
comprehensively
summarize
sources
BEVs
in
BEVs-related
strategies.
further
highlight
great
potential
bone
tumors.
Finally,
conclude
major
advantages
challenges
therapy.
believe
comprehensive
understanding
field
will
generate
innovative
solutions
achieve
clinical
applications.
