Energy storage materials, Год журнала: 2025, Номер unknown, С. 104220 - 104220
Опубликована: Март 1, 2025
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28245 - 28262
Опубликована: Май 21, 2024
Engineering bulk covalent organic frameworks (COFs) to access specific morphological structures holds paramount significance in boosting their functions cancer treatment; nevertheless, scant effort has been dedicated exploring this realm. Herein, silica core–shell templates and multifunctional COF-based reticulated hollow nanospheres (HCOFs) are novelly designed as a versatile nanoplatform investigate the simultaneous effect of dual-drug chemotherapy photothermal ablation. Taking advantage distinct structural properties template, resulting two-dimensional (2D) HCOF, featuring large internal voids peripheral interconnected mesoporous shell, presents intriguing benefits over its counterparts for treatment, including well-defined morphology, an outstanding drug loading capability (99.6%) attributed ultrahigh surface area (2087 m2/g), great crystallinity, improved tumor accumulation, adjustable release profile. After being loaded with hydrophilic doxorubicin remarkable capacity, obtained drug-loaded HCOFs were coated gold nanoparticles (Au NPs) confer them three properties, pore entrance blockage, active-targeting capability, biocompatibility via secondary modification, besides high near infrared (NIR) absorption efficient hyperthermia suppression. The resultant structure was functionalized mono-6-thio-β-cyclodextrin (β-CD) second pocket load docetaxel hydrophobic anticancer agent (combination index = 0.33). dual-drug-loaded HCOF displayed both pH- near-infrared-responsive on-demand release. In vitro vivo evaluations unveiled prominent synergistic performance coloaded elimination upon NIR light irradiation. This work opens up new avenue exciting applications structurally engineered hydrophobic/hydrophilic carriers well multimodal treatment agents.
Язык: Английский
Процитировано
7
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract Cisplatin (CDDP) combined with pemetrexed (MTA) is commonly employed in the treatment of advanced non‐small cell lung cancer. However, conventional clinical administration methods fail to achieve precise spatiotemporal delivery within tumor microenvironment (TME), resulting inadequate control local drug concentrations and impeding synergistic efficacy chemotherapeutic drugs. Aiming address this issue, Fe 2 O 3 hollow multi‐shelled structure (HoMS) nanocarriers spatiotemporally controlled release properties co‐encapsulated CDDP MTA into nanocarrier are developed. The confined provided by ‐HoMS enables a targeted temporal sequential tailored requirements. Furthermore, chemotherapy‐induced DNA damage leads apoptosis, accompanied substantial generation reactive oxygen species (ROS). disruption ROS homeostasis subsequently activates ferroptosis pathway mediated ‐HoMS. In summary, exhibits highly two drugs TME, HoMS further involved regulation ferroptosis, realizing triple system comprising CDDP‐MTA‐Fe 2+ thus significantly enhancing anti‐tumor against This study proposes novel approach for optimizing design, addressing challenge precisely tumors.
Язык: Английский
Процитировано
1
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1401 - 1423
Опубликована: Фев. 1, 2025
Abstract: Kidney stones constitute a common condition impacting the urinary system. In clinical diagnosis and management, traditional surgical interventions pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. Presently, field of nanomedicine is undergoing significant advancements. The application nanomaterials in biosensors enables accurate assessment ion composition. Furthermore, contrast agents developed from materials can improve signal-to-noise ratio enhance image clarity. By mitigating oxidative stress-induced cellular damage, inhibit formation kidney efficacy drug delivery as effective carriers. Additionally, by modifying physical chemical properties bacteria, effectively eliminate bacterial presence, thereby preventing severe complications. This review explores advancements technology related to early detection risk factors, diagnosis, treatment their associated Keywords: nanomaterials, stones, stress, biomaterial
Язык: Английский
Процитировано
1
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Designing and synthesizing multishelled metallic hollow nanostructures with intragaps porous shells have received widespread attention for enhancing optical catalytic properties. However, significant challenges remain in engineering these structures at the nanometer scale. Herein, we employed galvanic replacement reaction (GRR) method to prepare multimetallic superstructures 3D cavities distinct intragaps. By precise control of intragap distances (1–10 nm) composition distributions within a single entity, libraries were constructed. Using 4-nitrophenol reduction as model reaction, triple-shell Au@Pt–Ag nanoparticles approximately 1 nm exhibited rate 211.6 times higher than that commercial Pt/C catalysts. The nanoconfinement environment not only increases active sites but also promotes electron delocalization reactants, accelerating hydrogenation process both thermodynamically kinetically. Our work advances rational synthesis nanostructures, expanding their potential applications catalysis, plasmonics, biosensing.
Язык: Английский
Процитировано
1
Energy storage materials, Год журнала: 2025, Номер unknown, С. 104220 - 104220
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1