Atomic Engineering of Single‐Atom Nanozymes for Biomedical Applications

Advanced Materials, Год журнала: 2024, Номер 36(21)

Опубликована: Фев. 7, 2024

Single-atom nanozymes (SAzymes) showcase not only uniformly dispersed active sites but also meticulously engineered coordination structures. These intricate architectures bestow upon them an exceptional catalytic prowess, thereby captivating numerous minds and heralding a new era of possibilities in the biomedical landscape. Tuning microstructure SAzymes on atomic scale is key factor designing targeted with desirable functions. This review first discusses summarizes three strategies for their impact reactivity biocatalysis. The effects choices carrier, different synthesis methods, modulation first/second shell, type number metal centers enzyme-like activity are unraveled. Next, attempt made to summarize biological applications tumor therapy, biosensing, antimicrobial, anti-inflammatory, other from mechanisms. Finally, how designed regulated further realization diverse reviewed prospected. It envisaged that comprehensive presented within this exegesis will furnish novel perspectives profound revelations regarding SAzymes.

Язык: Английский

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Photogenerated carrier-accelerated 3D mesh-NH2 functionalized Zr-metal organic framework/MgAl-type hydrotalcite composites attacking diclofenac

Separation and Purification Technology, Год журнала: 2024, Номер 354, С. 128839 - 128839

Опубликована: Июль 16, 2024

Язык: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Год журнала: 2024, Номер 11(16)

Опубликована: Фев. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Язык: Английский

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Hierarchical CaZrO3@rGO nanostructure as an electrode material for high-performance supercapacitor devices

Diamond and Related Materials, Год журнала: 2024, Номер 148, С. 111391 - 111391

Опубликована: Июль 8, 2024

Язык: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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Ameliorating and Tuning the Structural, Morphological, and Optical Characteristics of Chromium Oxide/Silicon Carbide Promising Hybrid Nanocomposites Doped PMMA for Futuristic Nanoelectronics and Photonics Applications

Silicon, Год журнала: 2024, Номер 16(12), С. 5087 - 5095

Опубликована: Июнь 19, 2024

Язык: Английский

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Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization

Carbohydrate Polymers, Год журнала: 2024, Номер 345, С. 122574 - 122574

Опубликована: Авг. 6, 2024

Язык: Английский

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2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices

Advanced Science, Год журнала: 2024, Номер 11(31)

Опубликована: Июнь 18, 2024

Since two-dimensionalal (2D) materials have distinct chemical and physical properties, they are widely used in various sectors of modern technologies. In the domain diagnostic biodevices, particularly for point-of-care (PoC) biomedical diagnostics, 2D-based field-effect transistor biosensors (bio-FETs) demonstrate substantial potential. Here, this review article, operational mechanisms detection capabilities biosensing devices utilizing graphene, transition metal dichalcogenides (TMDCs), black phosphorus, other 2D addressed detail. The incorporation these into FET-based offers significant advantages, including low limits (LOD), real-time monitoring, label-free diagnosis, exceptional selectivity. also highlights diverse applications biosensors, ranging from conventional to wearable devices, underscoring versatility material-based FET devices. Additionally, provides a comprehensive assessment limitations challenges faced by along with insights future prospects advancements. Notably, detailed comparison is tabulated platforms their working mechanisms. Ultimately, aims stimulate further research innovation field while educating scientific community about latest advancements materials-based biosensors.

Язык: Английский

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Optimization, kinetic analysis, and photocatalytic degradation of rhodamine B using manganese doped nanoscale nickel oxide nanoparticles

Ceramics International, Год журнала: 2024, Номер 50(20), С. 38871 - 38883

Опубликована: Июль 17, 2024

Язык: Английский

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Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(26)

Опубликована: Фев. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Язык: Английский

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