Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
J‐aggregates
show
great
promise
in
phototherapy,
but
are
limited
to
specific
molecular
skeletons
and
poor
self‐assembly
controllability.
Herein,
we
report
a
twisted‐planar
strategy
with
sonication‐induced
J‐aggregation
develop
donor–acceptor
(D–A)
type
for
phototherapy.
With
propeller
aggregation‐induced
emission
(AIE)
moieties
as
the
twisted
subunits
thiophene
planar
π‐bridge,
optimal
π‐interaction
MTSIC
induces
appropriate
slip
angle
formation,
redshifting
absorption
from
624
nm
790
nm.
In
contrast,
shorter
π‐planarity
results
amorphous
aggregates,
elongation
promotes
charge
transfer
(CT)
coupled
J‐aggregates.
Sonication
was
demonstrated
be
effective
controlling
behaviors
of
MTSIC,
which
enables
transformation
aggregates
H‐intermediates,
finally
stable
After
encapsulation
lipid‐PEG,
resultant
J‐dots
enhanced
phototherapeutic
effects
over
dots,
including
brightness,
reactive
oxygen
species
(ROS)
generation,
photothermal
conversion,
delivering
superior
cancer
phototherapy
performance.
This
work
not
only
advances
D–A
design
also
provides
promising
supramolecular
assembly
development.
Journal of Innovative Optical Health Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 15, 2024
The
fluorescence
imaging
(FLI)
in
the
second
near-infrared
window
(NIR-II,
1000–1700[Formula:
see
text]nm)
has
attracted
considerable
attention
past
decade.
In
contrast
to
conventional
NIR-I
excitation
(808[Formula:
text]nm/980[Formula:
text]nm),
FLI
with
NIR-II
(1064[Formula:
text]nm/other
wavelength
beyond
1000[Formula:
can
afford
deeper
tissue
penetration
depth
high
clarity
due
merits
of
suppressed
photon
scattering
and
diminished
autofluorescence.
this
review,
we
have
summarized
excitable/emissive
organic/polymeric
fluorophores
recently
developed.
characteristics
these
such
as
chemical
structures
photophysical
properties
also
been
critically
discussed.
Furthermore,
latest
development
noninvasive
vivo
was
highlighted.
ideal
results
emphasized
importance
enabling
deep
high-resolution
imaging.
Finally,
a
perspective
on
challenges
prospects
We
expected
review
will
be
served
source
inspiration
for
researchers,
stimulating
creation
novel
excitable
fostering
bioimaging
applications.
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
Abstract
The
contradiction
of
near‐infrared
II
(NIR‐II)
emission
and
photothermal
effects
limits
the
development
phototheranostic
agents
(PTAs)
in
many
emerging
cutting‐edge
applications.
Organic
aggregates
present
a
promising
opportunity
for
balance
competitive
relaxation
processes
through
manipulation
molecular
structure
packing.
Herein,
side
chain
phenyl
isomerization‐induced
spatial
conjugation
was
proposed
constructing
A‐D‐A
type
NIR‐II
PTAs
with
simultaneous
enhancement
fluorescence
brightness
properties.
Three
pairs
mutually
isomeric
fluorophores,
whose
phenyls
respectively
located
at
outside
(
o
‐series)
inside
i
chain,
were
designed
synthesized.
positional
isomerization
endows
‐series
crystals
strong
between
group
on
backbone,
as
well
interlocked
planar
network,
which
is
different
to
that
observed
‐series.
Thus,
all
nanoparticles
(NPs)
exhibit
red‐shifted
absorption,
enhanced
emission,
superior
properties
than
their
counterparts.
A
prominent
member
‐series,
‐ITNP
NPs,
demonstrated
efficacy
facilitating
angiography,
tumor
localization,
imaging‐guided
therapy.
success
this
strategy
paves
way
precise
control
aggregation
behavior
further
efficient
PTAs.
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
J‐aggregates
show
great
promise
in
phototherapy,
but
are
limited
to
specific
molecular
skeletons
and
poor
self‐assembly
controllability.
Herein,
we
report
a
twisted‐planar
strategy
with
sonication‐induced
J‐aggregation
develop
donor–acceptor
(D–A)
type
for
phototherapy.
With
propeller
aggregation‐induced
emission
(AIE)
moieties
as
the
twisted
subunits
thiophene
planar
π‐bridge,
optimal
π‐interaction
MTSIC
induces
appropriate
slip
angle
formation,
redshifting
absorption
from
624
nm
790
nm.
In
contrast,
shorter
π‐planarity
results
amorphous
aggregates,
elongation
promotes
charge
transfer
(CT)
coupled
J‐aggregates.
Sonication
was
demonstrated
be
effective
controlling
behaviors
of
MTSIC,
which
enables
transformation
aggregates
H‐intermediates,
finally
stable
After
encapsulation
lipid‐PEG,
resultant
J‐dots
enhanced
phototherapeutic
effects
over
dots,
including
brightness,
reactive
oxygen
species
(ROS)
generation,
photothermal
conversion,
delivering
superior
cancer
phototherapy
performance.
This
work
not
only
advances
D–A
design
also
provides
promising
supramolecular
assembly
development.
