Advanced Materials,
Год журнала:
2023,
Номер
36(2)
Опубликована: Сен. 21, 2023
Abstract
Tumor
cells
movement
and
migration
are
inseparable
from
the
integrity
of
lipid
rafts
formation
lamellipodia,
also
a
prerequisite
for
lamellipodia.
Therefore,
destroying
is
an
effective
strategy
to
inhibit
tumor
metastasis.
Herein,
multi‐enzyme
co‐expressed
nanomedicine:
cholesterol
oxidase
(CHO)
loaded
Co─PN
3
single‐atom
nanozyme
(Co─PN
SA/CHO)
that
can
up‐regulate
cellular
oxidative
stress,
disrupt
rafts,
lamellipodia
induce
anti‐metastasis
therapy,
developed.
In
this
process,
SA
catalyze
oxygen
(O
2
)
hydrogen
peroxide
(H
O
generate
reactive
species
(ROS)
via
oxidase‐like
Fenton‐like
properties.
The
doping
P
atoms
optimizes
adsorption
process
intermediate
at
active
site
enhances
ROS
generation
properties
nanomedicine.
Meantime,
produced
by
catalase‐like
catalysis
combine
with
excess
more
H
under
CHO
catalysis,
achieving
enhanced
damage
cells.
Most
importantly,
depletion
in
disrupts
inhibits
greatly
inhibiting
proliferation
metastasis
This
up‐regulating
stress
depleting
constructs
new
idea
anti‐metastasis–oriented
cancer
therapy
strategies.
Nanozyme-based
colorimetric
sensors
are
promising
approaches
for
environmental
monitoring,
food
safety,
and
medical
diagnostics.
However,
developing
novel
nanozymes
that
exhibit
high
catalytic
activity,
good
dispersion
in
aqueous
solution,
sensitivity,
selectivity,
stability
is
challenging.
In
this
study,
the
first
time,
single-atom
iridium-doped
carbon
dot
(SA
Ir-CDs)
synthesized
via
a
simple
situ
pyrolysis
process.
Doping
dots
with
iridium
form
of
single
atoms
to
achieve
maximum
atomic
utilization
not
only
enhances
peroxidase
(POD)-like
activity
178.81
U
mg-1
but
also
improves
dispersibility
solutions
over
30
days.
Hence,
SA
Ir-CD
platform
developed
mercury
ions
(Hg2+)
detection
exhibited
linear
relationship
from
0.01
10
µm
limit
4.4
nm.
Notably,
changes
color
can
be
observed
through
naked
eye
smartphone,
enabling
convenient
field
onsite
monitoring
without
need
sophisticated
analytical
equipment.
an
approach
fabricating
metal-based
POD-like
developed,
new
effective
easy-to-use
sensor
Hg2+
constructed.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Photodynamic
therapy
(PDT)
holds
promise
as
a
cancer
treatment
modality
due
to
its
potential
for
enhanced
precision
and
safety.
To
enhance
deep
tissue
penetration
minimize
adsorption
phototoxicity,
developing
photosensitizers
activated
by
second
near-infrared
window
(NIR-II)
light
shows
significant
potential.
However,
the
efficacy
of
PDT
is
often
impeded
tumor
microenvironment
hypoxia,
primarily
caused
irregular
vasculature.
Fortunately,
stimulator
interferon
genes
(STING)
pathway,
known
immune
activation,
has
been
linked
vasculature
normalization.
In
this
study,
we
developed
nanoplatform
(Fe-THBQ/SR)
loading
STING
agonist
(SR-717)
into
an
iron-tetrahydroxy-1,4-benzoquinone
(Fe-THBQ)
metal–organic
framework.
Fe-THBQ
was
proven
be
effective
NIR-II
photosensitizer,
generating
numerous
reactive
oxygen
species
(ROS)
under
1064
nm
laser
irradiation.
These
ROS
downregulated
heat
shock
protein
expression,
consequently
promoting
mild-photothermal
(mild-PTT),
facilitated
ferroptosis
depleting
glutathione
(GSH)/glutathione
peroxidase
4.
Moreover,
Fe-THBQ/SR
released
SR-717
upon
GSH
stimulation,
synergizing
with
ROS-mediated
double-stranded
DNA
leakage
activation.
This
process
contributed
normalization
hypoxia
alleviation,
thereby
enhancing
efficacy.
Overall,
presented
versatile
single-laser-triggered
mild-PTT
simultaneously
coupled
it
activation
form
reinforcing
cycle.
synergistic
enhancements
increased
immunogenicity
cells,
remodeled
immunosuppressive
microenvironment,
T
lymphocyte
infiltration,
improved
therapeutic
outcomes.
Advanced Materials,
Год журнала:
2023,
Номер
36(2)
Опубликована: Сен. 21, 2023
Abstract
Tumor
cells
movement
and
migration
are
inseparable
from
the
integrity
of
lipid
rafts
formation
lamellipodia,
also
a
prerequisite
for
lamellipodia.
Therefore,
destroying
is
an
effective
strategy
to
inhibit
tumor
metastasis.
Herein,
multi‐enzyme
co‐expressed
nanomedicine:
cholesterol
oxidase
(CHO)
loaded
Co─PN
3
single‐atom
nanozyme
(Co─PN
SA/CHO)
that
can
up‐regulate
cellular
oxidative
stress,
disrupt
rafts,
lamellipodia
induce
anti‐metastasis
therapy,
developed.
In
this
process,
SA
catalyze
oxygen
(O
2
)
hydrogen
peroxide
(H
O
generate
reactive
species
(ROS)
via
oxidase‐like
Fenton‐like
properties.
The
doping
P
atoms
optimizes
adsorption
process
intermediate
at
active
site
enhances
ROS
generation
properties
nanomedicine.
Meantime,
produced
by
catalase‐like
catalysis
combine
with
excess
more
H
under
CHO
catalysis,
achieving
enhanced
damage
cells.
Most
importantly,
depletion
in
disrupts
inhibits
greatly
inhibiting
proliferation
metastasis
This
up‐regulating
stress
depleting
constructs
new
idea
anti‐metastasis–oriented
cancer
therapy
strategies.
