Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Год журнала: 2023, Номер 491, С. 215245 - 215245

Опубликована: Май 22, 2023

Язык: Английский

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Nanozyme-mediated biocatalysis as a mitochondrial oxidative stress amplifier for tumor nanocatalytic immunotherapy

Chemical Engineering Journal, Год журнала: 2023, Номер 481, С. 148270 - 148270

Опубликована: Дек. 23, 2023

Язык: Английский

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CuCo₂O₄ Nanoflowers with Multiple Enzyme Activities for Treating Bacterium-Infected Wounds via Cuproptosis-like Death

ACS Nano, Год журнала: 2024, Номер 18(24), С. 15845 - 15863

Опубликована: Июнь 4, 2024

Nanozyme-driven catalytic therapy provides a promising treatment strategy for bacterial biofilm-infected wounds. However, the single functionality and limited efficiency of nanozyme-based materials often restrict effectiveness wound infection treatment. In this study, CuCo2O4 nanoflowers with multiple enzymatic activities were prepared antibacterial/antibiofilm by cuproptosis-like death. exhibited peroxidase-like (POD-like) oxidase-like (OXD-like) dual enzyme that generated large amounts •OH O2•–. Moreover, glutathione (GSH-Px-like) activity was able to reduce overexpression GSH in microenvironment, enhancing therapeutic effects reactive oxygen species (ROS). The morphology modified using hydrothermal method PEG4000 as solvent, resulting exposure more active center sites significant improvement activity. vitro results demonstrated pronounced disruption effect on biofilms formed bacteria. vivo, significantly promoted angiogenesis, collagen deposition, cell proliferation. Transcriptome sequencing revealed elevated ROS levels bacteria led membrane damage metabolic disruption. addition, Cu2+ overload induces lipid peroxidation accumulation disrupts respiratory chain tricarboxylic acid (TCA) cycle, ultimately leading This strategy, which combines synergistic enzyme-like death, an approach treating biofilm infections.

Язык: Английский

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Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

Advanced Materials, Год журнала: 2023, Номер 35(44)

Опубликована: Июль 17, 2023

Abstract Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS 2 ) with Mg 2+ ‐doped polydopamine coating polysulfobetaines, a dual‐bionic photothermal nanozyme (MPMP) constructed mimic antioxidases/hyaluronan synthase OA therapy. Photothermally enhanced lubrication lowers the coefficient friction (0.028) early stage treatment. The antioxidases‐mimicking properties MPMP contribute eliminating reactive oxygen nitrogen species (ROS/RNS) (over 90% scavenging ratio H O /·OH/O · – /DPPH/ABTS + supplying . With NIR irradiation, triggers thermogenesis (upregulating HSP70 expression) release, which promotes chondrogenesis inflammatory conditions deactivating NF‐κB/IL‐17 signaling pathways enhancing MAPK pathway. Benefiting from , MPMP‐NIR shows HAS‐mimicking activity increase intracellular (twofold) extracellular (3.12‐fold) HA production. Therefore, demonstrates superior spatiotemporally therapeutic effect on mice model, terms osteophytes (83.41% reduction), OARSI scores (88.57% ACAN expression (2.70‐fold increment). Hence, insights into nanozymes can be promising strategy therapy or other inflammation‐related diseases.

Язык: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 849 - 868

Опубликована: Июль 18, 2024

Язык: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612

Опубликована: Март 21, 2024

Язык: Английский

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Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging

Analytical Chemistry, Год журнала: 2024, Номер 96(33), С. 13663 - 13671

Опубликована: Авг. 10, 2024

Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial for the early diagnosis prognosis breast cancer. In this study, we reported an iron-manganese ion N-doped carbon single-atom catalyst (FeMn-NC

Язык: Английский

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Advances in the application of metal oxide nanozymes in tumor detection and treatment

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 235, С. 113767 - 113767

Опубликована: Янв. 24, 2024

Язык: Английский

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Nanozymes: powerful catalytic materials for environmental pollutant detection and degradation

Environmental Science Nano, Год журнала: 2024, Номер 11(3), С. 766 - 796

Опубликована: Янв. 1, 2024

Here we made a critical review on nanozyme-involved detection and degradation of environmental pollutants, the research progress achieved in last five years was emphatically concluded.

Язык: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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