Chirality‐Dependent Angiogenic Activity of MoS2 Quantum Dots toward Regulatable Tissue Regeneration DOI

Kangqiang Liang,

Yumeng Xue, Bin Zhao

и другие.

Small, Год журнала: 2023, Номер 19(49)

Опубликована: Авг. 17, 2023

Despite great advances in understanding the biological behaviors of chiral materials, effect chirality-configured nanoparticles on tissue regeneration-related processes remains poorly understood. Herein, chirality MoS2 quantum dots (QDs) is tailored by functionalization with l-/d-penicillamine, and profound effects QDs cellular activities, angiogenesis, regeneration are thoroughly investigated. Specifically, d-MoS2 show a positive promoting growth, proliferation, migration human umbilical vein endothelial cells. The expression vascular growth factor (VEGF), nitric oxide synthase (eNOS), fibroblast (FGF) group substantially up-regulated, resulting enhanced tube formation activity. This distinct phenomenon largely due to higher internalization efficiency than l-MoS2 chirality-dependent nano-bio interactions. In vivo angiogenic assay shows level markers newly-formed skin tissues that group, leading an accelerated re-epithelialization improved regeneration. findings angiogenesis activity provide new insights into nanomaterials, which also opens up path rational design nanomaterials for application.

Язык: Английский

Platinum Nanoparticles Regulated V2C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐Infective Therapy DOI
Xiaojun He,

Ya Lv,

Yanling Lin

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(25)

Опубликована: Март 12, 2024

Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) therapy (PTT). However, limitation MXene's laser irradiation to near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached C, forming artificial nanoplatforms (Pt@V C). Pt@V exhibits enhanced PCE (59.6%) a longer (NIR‐II) due surface plasmon resonance effect NPs C. Notably, displays dual enzyme‐like activity chemodynamic (CDT) NIR‐II activity. The biocatalytic mechanism is elucidated using density functional theory. In an vivo animal model, effectively eliminates methicillin‐resistant Staphylococcus aureus from deep‐seated tissues subcutaneous abscesses keratitis environments, accelerating abscess resolution promoting wound cornea healing through synergistic effects PTT/CDT. Transcriptomic analysis reveals that targets inflammatory pathways, providing insight into its mechanism. This study presents promising approach involving hyperthermia‐amplified biocatalysis MXene nanocomposites.

Язык: Английский

Процитировано

70
Transition Metal High‐Entropy Nanozyme: Multi‐Site Orbital Coupling Modulated High‐Efficiency Peroxidase Mimics DOI Creative Commons

Jianxing Feng,

Xuewei Yang, Ting Du

и другие.

Advanced Science, Год журнала: 2023, Номер 10(33)

Опубликована: Окт. 23, 2023

Strong substrate affinity and high catalytic efficiency are persistently pursued to generate high-performance nanozymes. Herein, with unique surface atomic configurations distinct d-orbital coupling features of different metal components, a class highly efficient MnFeCoNiCu transition high-entropy nanozymes (HEzymes) is prepared for the first time. Density functional theory calculations demonstrate that improved between metals increases electron density near Fermi energy level (EF ) shifts position overall d-band center respect EF , thereby boosting site-to-site transfer while also enhancing adsorption oxygen intermediates during catalysis. As such, proposed HEzymes exhibit superior affinities efficiencies comparable natural horseradish peroxidase (HRP). Finally, superb (POD)-like activity used in biosensing antibacterial applications. These results suggest have great potential as new-generation

Язык: Английский

Процитировано

60
Emerging 2D MXenes for antibacterial applications: Current status, challenges, and prospects DOI
Xiaojun He, Seyoung Koo, Enoch Obeng

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 492, С. 215275 - 215275

Опубликована: Июнь 7, 2023

Язык: Английский

Процитировано

59
High‐Entropy Photothermal Materials DOI
Cheng‐Yu He, Yang Li,

Zhuo‐Hao Zhou

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(24)

Опубликована: Март 4, 2024

Abstract High‐entropy (HE) materials, celebrated for their extraordinary chemical and physical properties, have garnered increasing attention broad applications across diverse disciplines. The expansive compositional range of these materials allows nuanced tuning properties innovative structural designs. Recent advances been centered on versatile photothermal conversion capabilities, effective the full solar spectrum (300–2500 nm). HE effect, coupled with hysteresis diffusion, imparts desirable thermal stability. These attributes position as a revolutionary alternative to traditional signifying transformative shift in technology. This review delivers comprehensive summary current state knowledge regarding emphasizing intricate relationship between compositions, structures, light‐absorbing mechanisms, optical properties. Furthermore, outlines notable contributions areas, such water evaporation, personal management, thermoelectric generation, catalysis, biomedical applications. culminates presenting roadmap that prospective directions future research this burgeoning field, also fruitful ways develop advanced expand promising

Язык: Английский

Процитировано

46
Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections DOI Creative Commons
Panchanathan Manivasagan, Thavasyappan Thambi,

Ara Joe

и другие.

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101292 - 101292

Опубликована: Апрель 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Язык: Английский

Процитировано

45
Synergistic Densification in Hybrid Organic‐Inorganic MXenes for Optimized Photothermal Conversion DOI
Tong Xu,

Shujuan Tan,

Shaoxiong Li

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(29)

Опубликована: Март 15, 2024

Abstract Optimizin the efficient light‐trapping in photothermal conversion by enhancing localized surface plasmon resonance (LSPR) is crucial improving light‐heat‐conversion efficiency of Ti 3 C 2 T x MXene. However, its susceptibility to oxidation makes it prone oxides formation, diminishing metallic properties and significantly reducing LSPR effect. This work synthesizes a kind air‐stable hybrid MXenes synergistic densification strategy that incorporates sulfhydryl‐bonding between organic inorganic parts reacting MXene with thiocarboxylic acids. The resultant shortening electron transport pathways, enhanced charge density, generation additional electronic states around Fermi level collectively contribute an augmented Additionally, also demonstrate high‐temperature resistance reduced water interactions. These combined effects substantially elevate through acids modification, reaching evaporation rate 1.77 kg m −2 h −1 94.56% MXenes. approach paves way for design development three‐in‐one conversion.

Язык: Английский

Процитировано

44
Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy DOI Creative Commons
Qinzhou Zheng,

Cuimin Chen,

Yong Liu

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 965 - 992

Опубликована: Янв. 1, 2024

Abstract: Diabetic wounds pose a significant challenge to public health, primarily due insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places physical burden on patients' prognosis, but also amplifies the economic strain medical system in treating diabetic wounds. Currently, effectiveness of available treatments for is limited. However, there hope potential metal nanoparticles (MNPs) address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial pro-angiogenic properties, making them promising solution In addition, stimulate expression proteins that promote wound healing serve as drug delivery systems small-molecule drugs. By combining with other biomaterials such hydrogels chitosan, novel dressings can be developed revolutionize treatment present article provides comprehensive overview research progress utilization Building upon this foundation, we summarize underlying mechanisms involved discuss application delivery. Furthermore, provide an extensive analysis discussion clinical implementation dressings, while highlighting future prospects utilizing management. conclusion, represent strategy healing. Future directions include biological nanomaterials synthesize new or physicochemical properties Synthetic contain play role all stages healing, stable physiological environment wound-healing process. Keywords: nanoparticles, wound, delivery, activity

Язык: Английский

Процитировано

33
Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria DOI Creative Commons

Jie Shan,

Xu Jin,

Cong Zhang

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(5), С. 2298 - 2316

Опубликована: Янв. 26, 2024

Bacterial infection hampers wound repair by impeding the healing process. Concurrently, inflammation at site triggers production of reactive oxygen species (ROS), causing oxidative stress and damage to proteins cells. This can lead chronic wounds, posing severe risks. Therefore, eliminating bacterial reducing ROS levels are crucial for effective healing. Nanozymes, possessing enzyme-like catalytic activity, convert endogenous substances into highly toxic substances, such as ROS, combat bacteria biofilms without inducing drug resistance. However, current nanozyme model with single enzyme activity falls short meeting complex requirements antimicrobial therapy. Thus, developing nanozymes multiple enzymatic activities is essential. Herein, we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles (Ru-PC NPs) diverse aid infections. Under acidic conditions, due their glutathione (GSH) depletion peroxidase (POD)-like Ru-PC NPs combined H2O2 exhibit excellent antibacterial effects. in neutral environment, NPs, catalase (CAT) decompose O2, alleviating hypoxia ensuring sufficient supply. Furthermore, possess exceptional antioxidant capacity through superior superoxide dismutase (SOD) effectively scavenging excess nitrogen (RNS) environment. maintains balance system prevents inflammation. also promote polarization macrophages from M1 M2, facilitating More importantly, show good biosafety negligible toxicity. In vivo models have confirmed efficacy inhibiting promoting The focus this work highlights quadruple its potential reduce bacteria-infected

Язык: Английский

Процитировано

32
Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra-Thin Electromagnetic Wave Absorber DOI Creative Commons

Honghan Wang,

Xinyu Xiao,

Shangru Zhai

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Сен. 26, 2024

Abstract The synthesis of carbon supporter/nanoscale high-entropy alloys (HEAs) electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering conductive/dielectric genes. Electron migration modes within HEAs manipulated electronegativity, valence electron configurations and molar proportions constituent elements determine steady state efficiency equivalent dipoles. Herein, enlightened skin-like effect, a reformative using carbonized cellulose paper (CCP) supporter is used to preserve oxygen-containing functional groups (O·) fibers (CCF). Nucleation construction emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked metabolism induced O·. Meanwhile, mode switchable electron-rich sites promotes orientation polarization anisotropic By virtue reinforcement strategy, CCP/HEAs composite prepared 35% ratio Mn element (CCP/HEAs-Mn 2.15 ) achieves efficient wave (EMW) absorption − 51.35 dB at ultra-thin thickness 1.03 mm. mechanisms resulting dielectric properties HEAs-based EMW absorbing materials elucidated combining theoretical calculations with experimental characterizations, which provide bases feasible strategies simulation practical application devices (e.g., ultra-wideband bandpass filter).

Язык: Английский

Процитировано

31
Atom-Dominated Relay Catalysis of High-Entropy MXene Promotes Cascade Polysulfide Conversion for Lithium-Sulfur Batteries DOI

Mengyao Xu,

Qizhen Zhu, Yanze Li

и другие.

Energy & Environmental Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The high-entropy TiVNbMoC 3 MXene, with its atom-dominated relay catalysis effect and resilient lattice configuration, promotes a cascade of sulfur conversions guides uniform Li + deposition, enabling shuttle-free dendrite-free Li–S batteries.

Язык: Английский

Процитировано

20