Despite
great
advances
in
understanding
the
biological
behaviors
of
chiral
materials,
effect
chirality-configured
nanoparticles
on
tissue
regeneration-related
processes
remains
poorly
understood.
Herein,
chirality
MoS2
quantum
dots
(QDs)
is
tailored
by
functionalization
with
l-/d-penicillamine,
and
profound
effects
QDs
cellular
activities,
angiogenesis,
regeneration
are
thoroughly
investigated.
Specifically,
d-MoS2
show
a
positive
promoting
growth,
proliferation,
migration
human
umbilical
vein
endothelial
cells.
The
expression
vascular
growth
factor
(VEGF),
nitric
oxide
synthase
(eNOS),
fibroblast
(FGF)
group
substantially
up-regulated,
resulting
enhanced
tube
formation
activity.
This
distinct
phenomenon
largely
due
to
higher
internalization
efficiency
than
l-MoS2
chirality-dependent
nano-bio
interactions.
In
vivo
angiogenic
assay
shows
level
markers
newly-formed
skin
tissues
that
group,
leading
an
accelerated
re-epithelialization
improved
regeneration.
findings
angiogenesis
activity
provide
new
insights
into
nanomaterials,
which
also
opens
up
path
rational
design
nanomaterials
for
application.
Advanced Materials,
Год журнала:
2024,
Номер
36(25)
Опубликована: Март 12, 2024
Abstract
Given
the
challenge
of
multidrug
resistance
in
antibiotics,
non‐antibiotic–dependent
antibacterial
strategies
show
promise
for
anti‐infective
therapy.
V
2
C
MXene‐based
nanomaterials
have
demonstrated
strong
biocompatibility
and
photothermal
conversion
efficiency
(PCE)
therapy
(PTT).
However,
limitation
MXene's
laser
irradiation
to
near‐infrared
region
I
(NIR‐I)
restricts
tissue
penetration,
making
it
difficult
achieve
complete
bacterial
eradication
with
single‐effect
therapeutic
strategies.
To
address
this,
Pt
nanoparticles
(Pt
NPs)
are
attached
C,
forming
artificial
nanoplatforms
(Pt@V
C).
Pt@V
exhibits
enhanced
PCE
(59.6%)
a
longer
(NIR‐II)
due
surface
plasmon
resonance
effect
NPs
C.
Notably,
displays
dual
enzyme‐like
activity
chemodynamic
(CDT)
NIR‐II
activity.
The
biocatalytic
mechanism
is
elucidated
using
density
functional
theory.
In
an
vivo
animal
model,
effectively
eliminates
methicillin‐resistant
Staphylococcus
aureus
from
deep‐seated
tissues
subcutaneous
abscesses
keratitis
environments,
accelerating
abscess
resolution
promoting
wound
cornea
healing
through
synergistic
effects
PTT/CDT.
Transcriptomic
analysis
reveals
that
targets
inflammatory
pathways,
providing
insight
into
its
mechanism.
This
study
presents
promising
approach
involving
hyperthermia‐amplified
biocatalysis
MXene
nanocomposites.
Strong
substrate
affinity
and
high
catalytic
efficiency
are
persistently
pursued
to
generate
high-performance
nanozymes.
Herein,
with
unique
surface
atomic
configurations
distinct
d-orbital
coupling
features
of
different
metal
components,
a
class
highly
efficient
MnFeCoNiCu
transition
high-entropy
nanozymes
(HEzymes)
is
prepared
for
the
first
time.
Density
functional
theory
calculations
demonstrate
that
improved
between
metals
increases
electron
density
near
Fermi
energy
level
(EF
)
shifts
position
overall
d-band
center
respect
EF
,
thereby
boosting
site-to-site
transfer
while
also
enhancing
adsorption
oxygen
intermediates
during
catalysis.
As
such,
proposed
HEzymes
exhibit
superior
affinities
efficiencies
comparable
natural
horseradish
peroxidase
(HRP).
Finally,
superb
(POD)-like
activity
used
in
biosensing
antibacterial
applications.
These
results
suggest
have
great
potential
as
new-generation
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 4, 2024
Abstract
High‐entropy
(HE)
materials,
celebrated
for
their
extraordinary
chemical
and
physical
properties,
have
garnered
increasing
attention
broad
applications
across
diverse
disciplines.
The
expansive
compositional
range
of
these
materials
allows
nuanced
tuning
properties
innovative
structural
designs.
Recent
advances
been
centered
on
versatile
photothermal
conversion
capabilities,
effective
the
full
solar
spectrum
(300–2500
nm).
HE
effect,
coupled
with
hysteresis
diffusion,
imparts
desirable
thermal
stability.
These
attributes
position
as
a
revolutionary
alternative
to
traditional
signifying
transformative
shift
in
technology.
This
review
delivers
comprehensive
summary
current
state
knowledge
regarding
emphasizing
intricate
relationship
between
compositions,
structures,
light‐absorbing
mechanisms,
optical
properties.
Furthermore,
outlines
notable
contributions
areas,
such
water
evaporation,
personal
management,
thermoelectric
generation,
catalysis,
biomedical
applications.
culminates
presenting
roadmap
that
prospective
directions
future
research
this
burgeoning
field,
also
fruitful
ways
develop
advanced
expand
promising
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101292 - 101292
Опубликована: Апрель 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Март 15, 2024
Abstract
Optimizin
the
efficient
light‐trapping
in
photothermal
conversion
by
enhancing
localized
surface
plasmon
resonance
(LSPR)
is
crucial
improving
light‐heat‐conversion
efficiency
of
Ti
3
C
2
T
x
MXene.
However,
its
susceptibility
to
oxidation
makes
it
prone
oxides
formation,
diminishing
metallic
properties
and
significantly
reducing
LSPR
effect.
This
work
synthesizes
a
kind
air‐stable
hybrid
MXenes
synergistic
densification
strategy
that
incorporates
sulfhydryl‐bonding
between
organic
inorganic
parts
reacting
MXene
with
thiocarboxylic
acids.
The
resultant
shortening
electron
transport
pathways,
enhanced
charge
density,
generation
additional
electronic
states
around
Fermi
level
collectively
contribute
an
augmented
Additionally,
also
demonstrate
high‐temperature
resistance
reduced
water
interactions.
These
combined
effects
substantially
elevate
through
acids
modification,
reaching
evaporation
rate
1.77
kg
m
−2
h
−1
94.56%
MXenes.
approach
paves
way
for
design
development
three‐in‐one
conversion.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 965 - 992
Опубликована: Янв. 1, 2024
Abstract:
Diabetic
wounds
pose
a
significant
challenge
to
public
health,
primarily
due
insufficient
blood
vessel
supply,
bacterial
infection,
excessive
oxidative
stress,
and
impaired
antioxidant
defenses.
The
aforementioned
condition
not
only
places
physical
burden
on
patients'
prognosis,
but
also
amplifies
the
economic
strain
medical
system
in
treating
diabetic
wounds.
Currently,
effectiveness
of
available
treatments
for
is
limited.
However,
there
hope
potential
metal
nanoparticles
(MNPs)
address
these
issues.
MNPs
exhibit
excellent
anti-inflammatory,
antioxidant,
antibacterial
pro-angiogenic
properties,
making
them
promising
solution
In
addition,
stimulate
expression
proteins
that
promote
wound
healing
serve
as
drug
delivery
systems
small-molecule
drugs.
By
combining
with
other
biomaterials
such
hydrogels
chitosan,
novel
dressings
can
be
developed
revolutionize
treatment
present
article
provides
comprehensive
overview
research
progress
utilization
Building
upon
this
foundation,
we
summarize
underlying
mechanisms
involved
discuss
application
delivery.
Furthermore,
provide
an
extensive
analysis
discussion
clinical
implementation
dressings,
while
highlighting
future
prospects
utilizing
management.
conclusion,
represent
strategy
healing.
Future
directions
include
biological
nanomaterials
synthesize
new
or
physicochemical
properties
Synthetic
contain
play
role
all
stages
healing,
stable
physiological
environment
wound-healing
process.
Keywords:
nanoparticles,
wound,
delivery,
activity
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2298 - 2316
Опубликована: Янв. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Сен. 26, 2024
Abstract
The
synthesis
of
carbon
supporter/nanoscale
high-entropy
alloys
(HEAs)
electromagnetic
response
composites
by
carbothermal
shock
method
has
been
identified
as
an
advanced
strategy
for
the
collaborative
competition
engineering
conductive/dielectric
genes.
Electron
migration
modes
within
HEAs
manipulated
electronegativity,
valence
electron
configurations
and
molar
proportions
constituent
elements
determine
steady
state
efficiency
equivalent
dipoles.
Herein,
enlightened
skin-like
effect,
a
reformative
using
carbonized
cellulose
paper
(CCP)
supporter
is
used
to
preserve
oxygen-containing
functional
groups
(O·)
fibers
(CCF).
Nucleation
construction
emblematic
shell-core
CCF/HEAs
heterointerfaces
are
inextricably
linked
metabolism
induced
O·.
Meanwhile,
mode
switchable
electron-rich
sites
promotes
orientation
polarization
anisotropic
By
virtue
reinforcement
strategy,
CCP/HEAs
composite
prepared
35%
ratio
Mn
element
(CCP/HEAs-Mn
2.15
)
achieves
efficient
wave
(EMW)
absorption
−
51.35
dB
at
ultra-thin
thickness
1.03
mm.
mechanisms
resulting
dielectric
properties
HEAs-based
EMW
absorbing
materials
elucidated
combining
theoretical
calculations
with
experimental
characterizations,
which
provide
bases
feasible
strategies
simulation
practical
application
devices
(e.g.,
ultra-wideband
bandpass
filter).
Energy & Environmental Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
high-entropy
TiVNbMoC
3
MXene,
with
its
atom-dominated
relay
catalysis
effect
and
resilient
lattice
configuration,
promotes
a
cascade
of
sulfur
conversions
guides
uniform
Li
+
deposition,
enabling
shuttle-free
dendrite-free
Li–S
batteries.