MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical biochemical in cells. However, the influence of biomimetic "rejuvenation" ECM structures on aging- degeneration-related cellular activities tissue repair is not well understood. We combined physical extrusion precise "on–off" alternating cross-linking methods to create anisotropic biomaterial microgels (MicroRod MicroSphere) explored how they regulate cell nucleus pulposus (NP) their potential antidegenerative effects intervertebral discs. NP cells exhibited aligned growth along surface MicroRod, enhanced proliferation, reduced apoptosis. This suggests an adaptive response involving adhesion mechanosensing, which causes cytoskeletal extension via environmental cues. maintain nuclear membrane integrity through YAP/TAZ pathway, activates cGAS-STING pathway rectify aging mechanisms. In vivo, MicroRod carries reduces inflammatory factor protease secretion degenerated discs, inhibiting degeneration promoting regeneration. Our findings highlight role stress maintaining activity antiaging harsh environments, providing a foundation for further research development biomaterials.

Язык: Английский

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Andrias davidianus Derived Glycosaminoglycans Direct Diabetic Wound Repair by Reprogramming Reparative Macrophage Glucolipid Metabolism

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent mediators angiogenesis inflammatory remodeling, facilitating efficient diabetic wounds. Mechanistic studies reveal SAGs promote macrophage polarization toward anti‐inflammatory pro‐regenerative phenotype (CD206 + /Arg1 ) via glucolipid metabolic reprogramming. This process suppresses excessive inflammation enhances expression VEGF IL‐10 create facilitative microenvironment regeneration. Additionally, develops SAGs‐GelMA composite microspheres address multiple stages healing, including rapid hemostasis, exudate control, activation endogenous processes. engineered approach significantly improves scarless wounds by recruitment reparative macrophages. findings offer new insights into highlight therapeutic application repair.

Язык: Английский

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Recent advances in microneedles for enhanced functional angiogenesis and vascular drug delivery

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Фев. 25, 2025

Many therapeutic applications use the transdermal method to avoid severe restrictions associated with oral medication delivery. Given limitations of traditional drug delivery via skin, microneedle (MN) arrays have been reported be versatile and very efficient devices due their outstanding characteristics such as painless penetration, affordability, excellent medicinal efficacy, relative safety. MNs recently received increased attention for ability cure vascular illnesses hypertension thrombosis, well promote wound healing angiogenesis impact. The integrant manufacturing biodegradable material allows modification MN form release pattern, hence increasing flexibility In this review, we focused on recent improvements in MN-mediated administration protein peptide medicines improved functional therapy. We also provide an overview present MNs-mediated administration, particularly realm system disease Finally, current state clinical translation a forecast future progress are provided.

Язык: Английский

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In vivo validation of a smart sensor-enabled dressing for remote wound monitoring

Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117474 - 117474

Опубликована: Апрель 1, 2025

Язык: Английский

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Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Small, Год журнала: 2023, Номер 20(18)

Опубликована: Дек. 1, 2023

Abstract Wounds and the subsequent formation of scars constitute a unified complex phased process. Effective treatment is crucial; however, diverse therapeutic approaches for different wounds scars, as well varying needs at stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), novel minimally invasive transdermal drug delivery system, has potential integrated programmed various diseases shown promising applications types scars. In this comprehensive review, latest biotechnological innovations MNPs these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, manage related symptoms. Moreover, scenarios discussed. Additionally, side effects, manufacturing processes, material selection explore clinical translational investigated. This groundwork can provide theoretical basis serve catalyst future pursuit favorable options skin tissue regeneration.

Язык: Английский

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