Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 29, 2024
Abstract
Chronic
wounds,
particularly
those
associated
with
diabetes,
pose
a
significant
clinical
challenge
due
to
their
tendency
develop
biofilms
that
resist
conventional
antibiotic
treatments.
To
address
this
issue,
novel
therapeutic
strategy
utilizing
pH‐responsive
nanoparticles
loaded
aggregation‐induced
emission
photosensitizers
and
natural
saturated
fatty
acids
(AIE/LA@HMONs−PyB)
for
effective
biofilm
penetration
disruption
is
proposed.
Under
physiological
conditions,
AIE/LA@HMONs−PyB
are
negatively
charged.
Upon
accumulation
at
infected
sites,
however,
the
pyridine
betaine
group
on
surface
of
enables
rapid
protonation
charge
reversal
in
acidic
microenvironment,
thereby
enhancing
ability
penetrate
biofilm.
light
irradiation,
these
generate
reactive
oxygen
species
effectively
disrupt
structure.
This
process
synergistic
action
ciprofloxacin
lower
concentration,
achieving
an
exceptional
vitro
antibacterial
efficiency
99.99%
against
methicillin‐resistant
Staphylococcus
aureus
(
S.
)
biofilms.
Furthermore,
vivo
diabetic
wound
model,
therapy
accelerates
healing
by
reducing
inflammation,
promoting
angiogenesis,
collagen
regeneration.
The
enhanced
significantly
improves
efficacy
combined
approach,
offering
great
promise
advancing
chronic
patient
outcomes.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(11), С. 13353 - 13383
Опубликована: Март 11, 2024
Biofilm
contamination
presents
a
significant
threat
to
public
health,
the
food
industry,
and
aquatic/marine-related
applications.
In
recent
decades,
although
various
methods
have
emerged
combat
biofilm
contamination,
intricate
persistent
nature
of
biofilms
makes
complete
eradication
challenging.
Therefore,
innovative
alternative
solutions
are
imperative
for
addressing
formation.
Instead
solely
focusing
on
mature
biofilms,
strategically
advantageous
measures
involve
delay
or
prevention
formation
surfaces.
Quorum
sensing,
communication
system
enabling
bacteria
coordinate
their
behavior
based
population
density,
plays
pivotal
role
in
numerous
microbial
species.
Materials
possessing
antibiofilm
properties
that
target
quorum
sensing
gained
considerable
attention
potential
prevent
This
Review
consolidates
research
progress
utilization
materials
with
antiquorum
combating
These
can
be
categorized
into
three
distinct
types:
(i)
nanomaterials,
(ii)
surfaces,
(iii)
hydrogels
capabilities.
Finally,
concludes
brief
discussion
current
challenges
outlines
avenues
future
research.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Окт. 27, 2023
Abstract
Although
near‐infrared
(NIR)
light‐based
photothermal
therapies
have
shown
therapeutic
potential
for
infected
wounds,
the
attenuation
of
NIR
light
intensity
in
tissue
has
severely
limited
usage
deep
bacterial
infections.
Herein,
magneto‐thermal
responsive
bilayer
microneedles
(Fe‐Se‐HA
MNs)
consisting
functionalized
hyaluronic
acid
(HA),
ferro‐ferric
oxide
(Fe
3
O
4
),
and
micelle‐protected
selenium
nanoparticles
(SeNPs@LAS)
are
constructed
to
overcome
this
challenge
based
on
a
self‐designed
disk‐shaped
electromagnetic
field
device
(Disk‐ZVS).
The
generated
by
Disk‐ZVS
shows
virtually
no
living
tissue.
Finite
element
simulations
showed
that
loss
concentrated
tips
Fe‐Se‐HA
MNs.
MNs
able
puncture
hard
scabs,
penetrate
into
biofilms,
perform
effective
magnetic‐thermal
conversion
hyperthermia
sterilization.
Following,
can
be
gradually
degraded
excessive
hyaluronidase
diabetic
wound
release
SeNPs,
which
reduce
reactive
oxygen
species
(ROS)
regulate
redox
homeostasis.
Meanwhile,
SeNPs
beneficial
angiogenesis,
facilitates
blood
vessel
formation
promotes
repair.
Therefore,
various
functions
achieved
MNs,
such
as
disinfection,
non‐invasive
penetration,
anti‐inflammation,
pro‐angiogenesis,
great
an
adjunctive
therapy
wounds.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 24055 - 24069
Опубликована: Дек. 4, 2023
Hydrogels
have
attracted
tremendous
attention
as
favorable
corneal
substitutes
for
treating
severe
infectious
keratitis
(IK).
However,
current
hydrogel-based
were
majorly
designed
to
promote
the
single
stage
of
regeneration,
which
falls
short
in
meeting
clinical
management
needs
IK
including
multiple
phases
wound
healing.
Herein,
we
introduce
a
versatile
hybrid
hydrogel
(SQPV)
composed
silk
fibroin
and
chitosan,
exhibits
spatiotemporal
properties
drug
release.
The
SQPV
is
fabricated
by
incorporating
verteporfin-loaded
poly(lactic-co-glycolic)-polyethylene
glycol-o-nitrobenzene
micelles
into
network,
formed
from
methacrylate
glycidyl
functionalized
quaternized
chitosan
containing
polydeoxyribonucleotide.
This
double
network
approach
results
material
with
exceptional
anti-inflammatory,
antibacterial,
proliferative
stimulation
tissue
remodeling
regulation
capabilities.
Furthermore,
showcases
mechanical
strength
transparency
akin
those
native
cornea.
Extensive
vitro
vivo
studies
validate
SQPV's
ability
effectively
eliminate
residual
bacteria,
mitigate
inflammation,
foster
regeneration
epithelium
stroma,
prevent
scarring,
ultimately
expedite
In
summary,
SF/CS-based
may
represent
promising
substitute
comprehensive
repair
IK.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(29)
Опубликована: Июль 29, 2023
The
presence
of
a
biofilm
matrix
barrier
and
hypoxic
microenvironment
within
the
significantly
impedes
efficacy
photodynamic
therapy
for
bacterial
infections.
Herein,
phototherapeutic
nanoagent
with
type-I
behavior
nitric
oxide
(NO)
release
performance
is
reported
overcoming
biofilm-associated
infectious
diseases.
Sodium
nitroprusside
(SNP),
NO
donor,
loaded
onto
amino-modified
mesoporous
silica
nanoparticles
(MSN)
to
form
MSN@SNP
NPs.
resulting
are
further
modified
porphyrin-based
metal-organic
framework
(Ti-TCPP
MOF)
obtain
MSN@MOF/SNP
NPs
(MMS
NPs)
applications.
In
hypoxia
microenvironment,
MMS
enhance
permeability
induce
generation
hydroxyl
radical
(•OH)
superoxide
anion
(O2•-
)
via
Type-I
pathway
under
laser
irradiation.
Subsequently,
infections
effectively
eliminated
through
reactive
oxygen
species
(ROS)
gas
synergistic
therapy.
addition,
also
stimulates
collagen
deposition
promotes
angiogenesis
in
vivo.
Therefore,
efficiently
treat
biofilm-related
infections,
providing
an
alternative
approach
combat
Materials Horizons,
Год журнала:
2024,
Номер
11(19), С. 4781 - 4790
Опубликована: Янв. 1, 2024
Gold
nanoparticles
modified
with
ellagic
acid
are
prepared
via
a
simple
one-pot
hydrothermal
process,
showing
high,
broad-spectrum
antimicrobial
activities,
and
effective
biofilm
dispersion
against
antibiotic-resistant
ESKAPE
pathogens.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
Abstract
Polymyxins
have
been
regarded
as
an
efficient
therapeutic
against
many
life‐threatening,
multidrug
resistant
Gram‐negative
bacterial
infections;
however,
the
cytotoxicity
and
emergence
of
drug
resistance
associated
with
polymyxins
greatly
hindered
their
clinical
potential.
Herein,
reaction‐induced
self‐assembly
(RISA)
natural
aldehydes
in
aqueous
solution
is
presented.
The
resulting
assemblies
effectively
mask
positively
charged
nature
polymyxins,
reducing
cytotoxicity.
Moreover,
representative
PMB
A
4
(composed
polymyxin
B
(PMB)
(
E
)‐2‐heptenal
))
demonstrate
enhanced
binding
to
outer
membranes
exhibit
multiple
antimicrobial
mechanisms,
including
increased
membrane
permeability,
elevated
metabolism,
suppression
quorum
sensing,
reduced
ATP
synthesis,
potential
reduction
resistance.
Remarkably,
reverse
clinically
isolated
drug‐resistant
strains
bacteria,
demonstrating
exceptional
efficacy
preventing
eradicating
biofilms.
efficiently
eradicate
biofilm
infections
vivo
alleviate
inflammatory
response.
This
RISA
strategy
offers
a
practical
applicable
approach
minimize
side
effects,
resistance,
prevent
free
polymyxins.
Nano Letters,
Год журнала:
2024,
Номер
24(43), С. 13708 - 13717
Опубликована: Окт. 17, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
possess
immense
potential
for
targeted
and
controlled
release
of
therapeutics.
However,
the
rapid
responsiveness
to
ROS
sustained
antibacterial
drugs
are
often
limited
by
challenging
microenvironment
periodontitis.
Integrating
ROS-responsive
with
photocatalytic
technologies
presents
a
strategic
approach
overcome
these
limitations.
Herein,
pillararene-embedded
covalent
organic
framework
(PCOF)
incorporating
prodrug
thioacetal
(TA)
has
been
developed
treat
This
drug-loaded
nanoplatform,
namely
TA-loaded
PCOF,
utilizes
self-amplifying
property
enhance
therapeutic
efficacy.
PCOFs
demonstrate
exceptional
photosensitivity
generation
capabilities
when
employed
as
carriers.
When
exposed
ROS,
TA
within
nanoplatform
was
activated
cleaved
into
cinnamaldehyde
(CA),
highly
potent
compound.
By
leveraging
visible
light
activate
site-specific
infection
targeting,
PCOF
effectively
alleviated
periodontitis,
thereby
advancing
field
systems.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2939 - 2956
Опубликована: Март 1, 2024
Background:
Bacterial
endophthalmitis
is
an
acute
progressive
visual
threatening
disease
and
one
of
the
most
important
causes
blindness
worldwide.
Current
treatments
are
unsatisfactory
due
to
emergence
drug-resistant
bacteria
formation
biofilm.
Purpose:
The
aim
our
research
was
construct
a
novel
nano-delivery
system
with
better
antimicrobial
antibiofilm
effects.
Methods:
This
study
developed
antibiotic
nanoparticle
delivery
(MXF@UiO-UBI-PEGTK),
which
composed
(i)
moxifloxacin
(MXF)-loaded
UiO-66
as
core,
(ii)
bacteria-targeting
peptide
ubiquicidin
(UBI
29-41
)
immobilized
on
UiO-66,
(iii)
ROS-responsive
poly
(ethylene
glycol)-thioketal
(PEG-TK)
surface
shell.
Then
properties
newly
system,
including
biocompatibility,
toxicity,
release
percentage,
thermal
stability,
ability
targeting
bacteria,
synergistic
antibacterial
effects
bacterial
biofilms
endophthalmitis,
were
evaluated.
Results:
In
vitro,
MXF@UiO-UBI-PEGTK
exhibited
significant
excellent
property
against
Staphylococcus
aureus,
Pseudomonas
aeruginosa
,
methicillin-resistant
aureus
at
high
levels
ROS.
Moreover,
demonstrated
outstanding
efficacy
in
treating
vivo.
Conclusion:
bacteria-targeted
promotes
precise
effective
drugs
has
potential
for
clinical
application
endophthalmitis.
Keywords:
nanoparticles,
biofilms,
ROS-responsive,
