Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation

Medical Oncology, Год журнала: 2025, Номер 42(2)

Опубликована: Янв. 9, 2025

Язык: Английский

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Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 4087 - 4101

Опубликована: Июнь 3, 2024

Currently, the efficacy of albumin-bound paclitaxel (PTX@Alb) is still limited due to impaired PTX@Alb accumulation in tumors partly mediated by dense collagen distribution. Meanwhile, acquired immune resistance always occurs enhanced programmed cell death-ligand 1 (PD-L1) expression after treatment, which then leads tolerance. To fill these gaps, we newly revealed that tamoxifen (TAM), a clinically widely used adjuvant therapy for breast cancer with mitochondrial metabolism blockade capacity, could also be as novel effective PD-L1 and TGF-

Язык: Английский

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Activating the cGAS-STING Pathway by Manganese-Based Nanoparticles Combined with Platinum-Based Nanoparticles for Enhanced Ovarian Cancer Immunotherapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Recent research has demonstrated that activating the cGAS-STING pathway can enhance interferon production and activation of T cells. A manganese complex, called TPA-Mn, was developed in this context. The reactive oxygen species (ROS)-sensitive nanoparticles (NPMn) loaded with TPA-Mn are developed. NPMn activates via cGAS (i.e., 1.6-fold enhancement P-STING), which turn increases secretion pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-2). This promotes dendritic cell maturation, enhances infiltration cytotoxic lymphocytes, reduces percentage immunosuppressive regulatory In addition, it is crucial to emphasize cisplatin-induced DNA damage potentially trigger pathway. NPMn, combination low-dose NPPt, a carrier Cis(IV) prodrug capable causing damage, augments significantly tumor immune microenvironment (TIME). Furthermore, combined anti-PD-1 antibody, NPPt+NPMn shows synergistic efficacy both ovarian cancer peritoneal metastases recurrence models. It not only effectively eliminates tumors but also induces strong memory response, providing promising strategy for clinical management cancer. work offers design manganese-based immunotherapy.

Язык: Английский

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Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO₂@Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Despite the promise of sonodynamic therapy (SDT)-mediated immunotherapy, anticancer efficacy current sonosensitizers is greatly limited by immunosuppressive tumor microenvironment (TME) and their inability to selectively respond it. Herein, oxygen vacancy-rich MnO2@hydroxyapatite (Ca10(PO4)6(OH)2) core-shell nanospheres (denoted as Ov-MO@CPO) an advanced TME-responsive sonosensitizer for immunotherapy demonstrated. The Ov-MO@CPO maintains its structural integrity under neutral conditions but dissolves pH-sensitive hydroxyapatite shell acidic TME release active MnO2 core, which reinvigorates H2O2 consumption hypoxia alleviation due catalase-like activity. Furthermore, introduced vacancies optimize electronic structure Ov-MO@CPO, with states near Fermi level higher d-band center. It results in accelerated electron-hole pair separation lower catalytic energy barriers boost ultrasound (US)-initiated ROS production. These multimodal synergistic effects effectively reverse microenvironment, inhibiting growth metastasis 4T1 tumor-bearing mice. No evident toxic are observed normal mouse tissues. Additionally, when combined immune checkpoint inhibitor, Ov-MO@CPO-mediated SDT further improves effectiveness immunotherapy. This work affords a new avenue developing TME-dependent SDT-mediated

Язык: Английский

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Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 9, 2024

Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO 2 ) that was core coated with MnO shell followed by glucose oxidase (GOx) doping nanoplatform @MnO @GOx, HMG) to trigger ferroptosis adjuvant effects glutathione depletion and reactive oxygen species production. This cascade potentiation further sensitized radiotherapy enhancing DNA damage in 4T1 breast tumor cells. The combination of HMG nanoparticles effectively activated the damaged Mn 2+ -mediated cGAS-STING pathway vitro vivo. process had significant inhibitory on progression initiating an anticancer systemic response prevent distant recurrence achieve long-lasting suppression both primary tumors. Furthermore, as-prepared “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, demonstrated favorable contrast enhancement capabilities under GSH microenvironment. result highlighted potential as theranostic achieving molecular guided sensitization induced synergistic immunotherapy.

Язык: Английский

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Is an immune-oriented use of radiation therapy possible? An increasingly open question under the spotlight of immunotherapy

ONCOLOGIE, Год журнала: 2024, Номер 26(3), С. 487 - 491

Опубликована: Март 7, 2024

Abstract Historically, radiation therapy has been devoted to the achievement of local control both in early and advanced disease, palliation symptoms (i.e. pain), treatment cancer complications bone fractures, bleeding) advanced/metastatic cancer. Recently, discovery role as a trigger activate immune system led an increased interest among insiders regarding interaction between host reactions. The systemic effects are widely acknowledged be immunosuppressive immunostimulant, albeit there exists considerable uncertainty doses/fraction that can induce them. main aim this brief paper is describe anti-tumor responses following on basis selected doses/fraction.

Язык: Английский

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A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity

Biomaterials, Год журнала: 2025, Номер 317, С. 123094 - 123094

Опубликована: Янв. 7, 2025

Язык: Английский

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Bibliometric analysis of metformin as an immunomodulator (2013–2024)

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 8, 2025

Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited. This study extracted 640 relevant articles from Web of Science (WOS) Core Collection and conducted visual using Microsoft Excel, VOSviewer, CiteSpace. The findings showed that research immunomodulatory function metformin grown steadily since 2017, with China United States being leading contributors. These studies have mostly been published in journals such International Journal Molecular Sciences, Cancers, Frontiers Immunology, Scientific Reports. Keyword co-occurrence analysis highlighted metformin's role immunomodulator, particularly context tumor immune microenvironment, immunosuppressive checkpoints, derivatives. Recent application aging, autoimmune diseases, COVID-19, tuberculosis. Additionally, its regulating inflammation gut microbiota is also investigated. Overall, effects were investigated anti-tumor, antiviral, anti-aging, disease research. highlights scope use these fields, while significantly enhancing clinical value a repurposed drug.

Язык: Английский

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Bifunctional cascaded single-atom nanozymes for enhanced photodynamic immunotherapy through dual-depressing PD-L1 and regulating hypoxia

Biomaterials, Год журнала: 2025, Номер 317, С. 123106 - 123106

Опубликована: Янв. 11, 2025

Язык: Английский

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Ginsenoside RG3 Synergizes With STING Agonist to Reverse Cisplatin Resistance in Gastric Cancer

Food Science & Nutrition, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 1, 2025

ABSTRACT This study investigates the synergistic inhibitory effects of combining stimulator interferon genes (STING) agonist cyclic diadenylate monophosphate (c‐di‐AMP) and ginsenoside RG3 on cisplatin (DDP)‐resistant gastric cancer (GC) cells. The objective is to identify novel therapeutic targets offers insights for clinical management DDP resistance. Various techniques were employed, including western blot, MTT assay, colony formation scratch transwell tubule flow cytometry, Hoechst 33342 fluorescence staining, in vivo experiments, investigate potential mechanisms combined application STING reversing resistance cancer. combination markedly suppressed key malignant behaviors, proliferation, migration, invasion, angiogenesis SGC‐7901/DDP Additionally, this treatment inhibited epithelial‐mesenchymal transition (EMT) process stem cell‐like characteristics cells, while downregulating expression resistance‐related proteins. effectively suppresses growth proliferation Ginsenoside RG3, well‐documented its multifaceted properties, antioxidant, anti‐aging, anti‐cancer effects, widely used managing chemotherapy‐related side effects. Furthermore, enhances anti‐tumor immunity by regulating signal transduction. comprehensively evaluated efficacy through vitro demonstrating significant inhibition progression reversal drug These findings offer a robust theoretical foundation applications highlight new future research.

Язык: Английский

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