Chemical Engineering Journal, Год журнала: 2024, Номер 501, С. 157483 - 157483
Опубликована: Ноя. 7, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(23)
Опубликована: Март 4, 2024
Abstract Dendritic cell (DC) maturation is a crucial process for antigen presentation and the initiation of T cell‐mediated immune responses. Toll‐like receptors play pivotal roles in stimulating DC promoting presentation. Here, novel message RNA (mRNA) cancer vaccine reported that boosts antitumor efficacy by codelivering an mRNA encoding tumor TLR7/8 agonist (R848) to using supramolecular lipid nanoparticles (SMLNP) as delivery platform, which new ionizable (N2‐3L) remarkably enhances translation efficiency β‐cyclodextrin (β‐CD)‐modified (Lip‐CD) encapsulates R848. The incorporation R848 adjuvant into through noncovalent host–guest complexation significantly promotes after vaccination, thus resulting superior vivo. Moreover, further boosted synergized with checkpoint blockade potentiating anticancer capability cytotoxic lymphocytes infiltrated sites. This work indicates SMLNP shows brilliant potential next‐generation system development vaccines high efficacy.
Язык: Английский
Процитировано
18
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 3876 - 3900
Опубликована: Июнь 22, 2024
Despite the promising prospects of nanoparticles in oral drug delivery, process administration involves a complex transportation pathway that includes cellular uptake, intracellular trafficking, and exocytosis by intestinal epithelial cells, which are necessary steps for to enter bloodstream exert therapeutic effects. Current researchers have identified several crucial factors regulate interaction between including surface properties such as ligand modification, charge, hydrophilicity/hydrophobicity, protein corona formation, well holistic like particle size, shape, rigidity. Understanding these is essential enhancing transepithelial transport efficiency designing effective delivery systems. Therefore, this review provides comprehensive overview influence nanoparticles, elucidating underlying principles governing their impact on transport. The also outlines chosen parameters be considered subsequent design
Язык: Английский
Процитировано
18
Bioactive Materials, Год журнала: 2024, Номер 37, С. 51 - 71
Опубликована: Март 15, 2024
Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors. The pathological changes associated with IVDD include the excessive accumulation of reactive oxygen species (ROS), cellular pyroptosis, extracellular matrix (ECM) degradation. There are currently no approved specific molecular therapies for IVDD. In this study, we developed a multifunctional microenvironment-responsive metal-phenolic network release platform, termed TMP@Alg-PBA/PVA, which could treat (IL-1β)-induced (TA-Mn-PVP, TMP) released from platform targeted mitochondria to efficiently scavenge ROS reduce ECM Pyroptosis was suppressed through inhibition IL-17/ERK signaling pathway. These findings demonstrate versatility platform. And in rat model IVDD, TMP@Alg-PBA/PVA exhibited excellent therapeutic effects reducing progression disease. therefore, presents clinical potential treatment
Язык: Английский
Процитировано
16
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Exploration, Год журнала: 2024, Номер 4(5)
Опубликована: Март 5, 2024
Abstract Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and associated with gastrointestinal or systemic adverse effects. New delivery needed for the of IBD. Bacteria promising biocarriers, which can produce drugs in situ sense gut real time. Herein, we focus on recent studies engineered bacteria used IBD introduce application diagnosis. On this basis, current dilemmas future developments bacterial systems discussed.
Язык: Английский
Процитировано
14
Dentistry Journal, Год журнала: 2025, Номер 13(2), С. 79 - 79
Опубликована: Фев. 13, 2025
Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring potential of mRNA-based therapies preventing and treating oral Objectives: This narrative review aims to evaluate current status development its preclinical health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, cancer. Methods: The synthesizes findings from studies, including research conducted animal models vitro, assess modulate immune responses promote tissue regeneration cavity. Clinical trials were only mentioned context broader areas implementation such oncology immunotherapy. Results: studies highlight capacity vaccines enhance body's response facilitate repair processes. Despite these results, challenges persist delivering effectively within complex environment. These include stability, delivery mechanisms, modulation responses. Conclusions: While offer promise revolutionizing health care, they face notable limitations concerning safety, efficacy, clinical feasibility. Overcoming obstacles through further is essential unlock full translational ensure safe effective integration into practice.
Язык: Английский
Процитировано
1
Nano Today, Год журнала: 2024, Номер 56, С. 102286 - 102286
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
7
Chemical Society Reviews, Год журнала: 2024, Номер 53(19), С. 9582 - 9608
Опубликована: Янв. 1, 2024
Targeted protein degradation (TPD) has emerged as a revolutionary paradigm in drug discovery and development, offering promising avenue to tackle challenging therapeutic targets. Unlike traditional approaches that focus on inhibiting function, TPD aims eliminate proteins of interest (POIs) using modular chimeric structures. This is achieved through the utilization proteolysis-targeting chimeras (PROTACs), which redirect POIs E3 ubiquitin ligases, rendering them for by cellular ubiquitin-proteasome system (UPS). Additionally, other technologies such lysosome-targeting (LYTACs) autophagy-based degraders facilitate transportation endo-lysosomal or autophagy-lysosomal pathways degradation, respectively. Despite significant growth preclinical research, many fail progress beyond this stage development. Various factors contribute limited success agents, including hurdle inadequate delivery target site. Integrating into platforms could surmount challenges
Язык: Английский
Процитировано
5
Advanced Functional Materials, Год журнала: 2024, Номер 34(46)
Опубликована: Авг. 20, 2024
Abstract Mineral supplementation is crucial for human nutrition to facilitate appropriate growth, disease prevention, and improved reproductive health. The conventional forms of mineral involve an ionic form elements mixed with biomolecules; however, suffer from unfavorable reactions under acidic environment stomach, ROS generation, poor absorption in the small intestine. To address this, nanominerals (NMs) six essential are synthesized packed pH‐responsive microcapsule. Each NMs coated biomolecules that known rapidly absorb through intestinal epithelium. Microcapsules found intact at pH (pH: 2.0–6.5); selectively release ≥7.0. vitro study demonstrates mixture microcapsules biocompatible exhibits excellent scavenging ability physiological pH. Oral administration NMs‐loaded rats shows enhanced levels minerals, vitamin B12, hemoglobin, total antioxidant activity blood. liver, kidneys, spleen show expression Cu/Zn‐SOD Mn‐SOD enzymes due high bioavailability ZnO, Cu 2 O, MnO Thus, hold promise effectively stealth encapsulated nutrient materials stomach precisely deliver them
Язык: Английский
Процитировано
5
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0