Small, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug platform termed as NDs
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
7
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
The specific fluorescent detection of α-methyltryptamine (AMT) presents a great challenge because similar amine groups and benzene rings exist in variety amines. Here, we show the precise modulation electron-withdrawing strength π-conjugate bridge aldehyde-containing Schiff base-based probes for ultratrace AMT discrimination. It is found that different −C6H4, −C6H2N2, −C6H2Br2 as 2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF)-based can classify identify organic amines with nucleophilicities. Notably, probe bridge, denoted BrFS–TCF, which has highest electrophilicity recognition site, shows superior nM-level limit (LOD) an instant response time (<0.1 s) toward AMT. Especially, it excellent selectivity facing secondary amines, tertiary aromatic even primary present strategy would provide new pathway chemical substances structures properties especially fighting against illegal drugs.
Язык: Английский
Процитировано
0
Science Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Ultrasonics, Год журнала: 2025, Номер 151, С. 107611 - 107611
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2024, Номер 96(23), С. 9544 - 9550
Опубликована: Май 29, 2024
Nanobubbles play an important role in diverse fields, including engineering, medicine, and agriculture. Understanding the characteristics of individual nanobubbles is essential for comprehending fluid dynamics behaviors advancing nanoscale science across various fields. Here, we report a strategy based on nanopore sensors characterizing single-digit nanobubbles. We investigated sizes diffusion coefficients at different voltages. Additionally, finite element simulation molecular were introduced to account counterion concentration variation around nanopore. In particular, differences stability surface charge density under solution environments have been studied by ion-stabilized model DLVO theory. straightforward method mitigate nanobubble generation bulk reducing current noise sensing was suggested. The results hold significant implications enhancing understanding characterizations, especially nanofluid field.
Язык: Английский
Процитировано
3
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The convergence of nanotechnology and cancer therapeutics has opened new frontiers in the development advanced drug delivery systems. Among various nanocarriers, nanobubbles offer significant potential due to their unique properties, such as high payload capacity, responsiveness external stimuli like ultrasound, enhanced permeability retention (EPR) effects. Functionalizing these with chitosan, a naturally derived biopolymer known for its biocompatibility, biodegradability, ability enhance cellular uptake, further improves therapeutic efficacy. This review provides comprehensive analysis synthesis, functionalization, application chitosan-functionalized therapy. We discuss mechanism action, including targeted delivery, ultrasound-mediated release, immune modulation, alongside recent advancements challenges clinical translation. also explores future directions this rapidly evolving field, aiming insights into next-generation therapeutics.
Язык: Английский
Процитировано
3
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Human parathyroid hormone (1-34) (PTH) exhibits osteoanabolic and osteocatabolic effects, with shorter plasma exposure times favoring bone formation. Subcutaneous injection (SCI) is the conventional delivery route for PTH but faces low efficiency due to limited passive diffusion obstruction of vascular endothelial barrier, leading prolonged drug reduced effects. In this work, a microcurrent system (MDS) based on multimicrochannel microneedle arrays (MMAs) proposed, achieving high safety transdermal delivery. The internal microchannels MMAs are fabricated using high-precision 3D printing technology, providing concentrated safe electric field that not only accelerates movement also reversibly increases permeability by regulating actin cytoskeleton interendothelial junctions through Ca
Язык: Английский
Процитировано
2
Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 1 - 19
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
1