Small, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug platform termed as NDs
Язык: Английский
Fundamental Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(37), С. 49069 - 49082
Опубликована: Сен. 5, 2024
Transdermal drug delivery systems are highly appealing as a convenient manner applicable to wide variety of drugs. While most relies on only passive diffusion and suffers low transdermal efficiencies. Ultrasound motivation promotes penetration but still calls for improvement, because thin proportion the ultrasound energy is applied patch wasted in deeper portions biotissues. In this work, we develop enhanced delivery. The combination microsized air pockets piezoelectric soft structure enable conversion an intended into electric energy. intensified flow synergistic pressure field function simultaneously enhance efficacy related power motivation, size microscopic pockets, chemical molecules. temperature within process remains safe range, mild elevation causes color changes thermochromic patch, used indicate effective ultrasound-patch matching. A model pain release constructed, animal experiments that blood concentrations 100% higher than using even more remarkably when compared electric-field-motivated or static without external motivations.
Язык: Английский
Процитировано
0
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Процитировано
0
Small Structures, Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
The intervertebral disks (IVD) serve as shock absorbers in the spine. As largest avascular tissue human body, it has a limited capacity for regeneration. To address this issue, various innovative biomimetic materials have been explored to facilitate IVD regeneration at both microscopic and macroscopic levels. Techniques such electrostatic spinning fiber‐winding machines employed prepare materials. In review, physiological structure of is described, advanced studies on its microstructure are summarized. techniques used biomaterial development further investigated, that systematically explored. Specifically, article provides detailed description summary key features materials, including types loads they can withstand their regenerative effects. Finally, prospective outlook application presented.
Язык: Английский
Процитировано
0
Small, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Immunotherapy involving PDL1 degradation holds great potential in anti-tumor treatment. Optimal design of degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet-based novel drug platform termed as NDs
Язык: Английский
Процитировано
0