Degradable Microneedle Patch with Photothermal-Promoted Bacteria-Infected Wound Healing and Microenvironment Remodeling

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(25), С. 32017 - 32026

Опубликована: Июнь 14, 2024

Bacteria-infected wound healing is one of the most challenging issues in health management that attracting worldwide concerns. Despite great achievements with antibiotics, emergence antibiotic-resistance retarded process and also led to severe outcomes. Exploration novel antibiotics together amelioration efficacy desirable. Herein, a degradable microneedle patch (AAZH@MNs) was fabricated through incorporating near-infrared light responsive photothermal agents for sustained bacteria killing prevention biofilm formation. In addition, antibacterial could even remold microenvironment bacteria-infected wounds an effect, significantly facilitating process.

Язык: Английский

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Glycyrrhizic Acid Hydrogel Microparticles Encapsulated with MSC Exosomes for Wound Healing

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Hydrogel microparticles have been proved to be curative diabetic wounds. Current trends focus on the integration of bioactive matrix and their smart stimulus-responsive release meet complex demand regeneration in wound. In this paper, we present novel stem cell exosome-encapsulated Chinese herb glycyrrhizic acid (GA) hydrogel for wound healing. The integrated GA endows with antibacterial properties, while encapsulated exosomes impart them pro-angiogenesis ability. addition, as black phosphorus is incorporated into these hybrid microparticles, profile could controllable under near-infrared irradiation due excellent photothermal effect reversible phase transformation properties GA. Based features, demonstrated that can effectively kill bacteria, scavenge free radical, promote angiogenesis from vitro experiments. Besides, they also markedly accelerate healing process by down-regulating inflammation promoting collagen deposition bacteria-infected vivo These results indicate proposed exosome-integrated great potential clinical treatment.

Язык: Английский

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Skin Temperature‐Activated Multifunctional Thermoelectric Dressing for Bacterial Infected Wound Treatment

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Abstract Endogenous electric field (EEF) is weakened in wounds due to electrolyte loss, hindering wound repair. Reshaping and repairing EEF play important roles accelerating healing. The design of antibacterial dressings coupled with an recovery ability promote healing urgent significant. Herein, a self‐powered wearable thermoelectric dressing antibacterial, antioxidant, reshaping activities for methicillin‐resistant Staphylococcus aureus ‐infected therapy fabricated. based on device constructed polyanionic hydrogel loaded tannic acid (TA). By taking advantage the natural temperature difference between infected external environment, activated convert thermal energy into electricity, producing continuous compensating reshape damaged stimulate tissue regeneration. Combined antioxidant properties TA released from hydrogel, can accelerate vivo by topical targeted sterilization, reducing inflammation wounds. Thus, this provides promising facile therapeutic strategy without need stimuli treat

Язык: Английский

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Plant-Derived Materials for Biomedical Applications

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

With exceptional biocompatibility and biodegradability, plant-derived materials have garnered significant interest for a myriad of biomedical applications. This mini-review presents concise overview prevalent materials, encompassing polysaccharide-based polymers, protein-based extracellular vesicles, mucilage, decellularized scaffolds, whole plant-based biomass. Through different processing techniques, these can be tailored into variety forms, such as nanoparticles, nanofibers, hydrogels, to address the nuanced requirements emphasis on wound healing, tissue engineering, drug delivery, this review underscores unique advantages lower risk endotoxin virus contamination, reduced ethical concerns, scalability, eco-friendly attributes. However, challenges need development standardized isolation methods further transition from preclinical clinical applications still remain solved.

Язык: Английский

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Next‐Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel‐Based Pharmaceuticals for Inflammation Regulation

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Oral ulcers, affecting 27.9% of adults, can lead to malnutrition and dehydration, especially in individuals with diabetes, cancer, viral infections, autoimmune diseases. Existing treatments-including oral films, sprays, frosts, powders-often fail be effective due rapid dilution clearance the moist environment. This study is first investigate use Cold Atmospheric Plasma (CAP) for treating ulcers its underlying molecular mechanisms. A novel high-bioavailability, mucoadhesive therapy combining handheld three dimensions (3D) multi-microhole CAP developed a nanogel-based pharmaceutical system containing glucose oxidase (GOx) catalase (CAT), termed GCN. These results showed that both alone combined GCN significantly accelerate ulcer healing, modulate immune responses, activate Epidermal Growth Factor Receptor (EGFR) acetic acid-induced outperforming untreated controls conventional medication, Watermelon Frost (WF). Furthermore, CAP+GCN combination enhances therapeutic effects by promoting fibroblast generation. pretreatment also cell permeability nanoparticle uptake, improving tissue adhesion. findings are validated primary Human Gingival Fibroblasts (HGF) Periodontal Ligament Stem Cells (PDLSC) from healthy donors, as well an model rats, demonstrating superior biocompatibility safety.

Язык: Английский

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External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

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MoS₂ Nanozyme–Chlorella Hydrogels: Pioneering a Hepatocellular Carcinoma Integrative Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Hepatocellular carcinoma (HCC) poses a formidable challenge to global health, and surgical resection is the predominant therapeutic strategy. However, efficacy of postoperative adjuvant treatments often compromised by need preserve liver function. The authors’ meta‐analysis reveals significant correlation between impaired function decreased survival rates in HCC patients, highlighting critical for interventions protect To address this, an innovative injectable composite hydrogel system engineered, designated MC@PHDA, which encapsulates Molybdenum disulfide MoS 2 nanozymes Chlorella photosensitizers within hyaluronic acid‐dopamine/2‐aminoethyl methacrylate (HA‐DA/AMA) matrix. This offers comprehensive approach HCC, combining photodynamic photothermal therapies selectively target eradicate cancer cells; while, inducing immunogenic cell death (ICD) stimulate antitumor immune response. MC@PHDA leverages ROS‐scavenging properties mitigate oxidative injury promote hepatocyte regeneration. Thus, multifaceted design represents paradigm‐shifting strategy treatment that targets tumor concurrently promoting repair study introduces groundbreaking integrative management with potential significantly enhance patient quality life.

Язык: Английский

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Multifunctional coaxial gelatin/polylactic acid three-dimensional nanofibrous scaffolds for diabetic wounds

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141525 - 141525

Опубликована: Фев. 1, 2025

Язык: Английский

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Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113582 - 113582

Опубликована: Март 1, 2025

Язык: Английский

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Fire cupping inspired negative-pressure microneedle syringes loaded with herb berberine-based nano composite for psoriasis therapy

Biomaterials Advances, Год журнала: 2025, Номер 173, С. 214259 - 214259

Опубликована: Март 5, 2025

Язык: Английский

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