Super‐Tough, Non‐Swelling Zwitterionic Hydrogel Sensor Based on the Hofmeister Effect for Potential Motion Monitoring of Marine Animals

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 10, 2024

Hydrogel-based electronic devices in aquatic environments have sparked widespread research interest. Nevertheless, the challenge of developing hydrogel electronics underwater has not been profoundly surmounted because fragility and swelling hydrogels environments. In this work, a zwitterionic double network comprised polyvinyl alcohol (PVA), poly(sulfobetaine methacrylate) (PSBMA), sulfuric acid (H

Язык: Английский

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Deep-Learning-Based Analysis of Electronic Skin Sensing Data

Sensors, Год журнала: 2025, Номер 25(5), С. 1615 - 1615

Опубликована: Март 6, 2025

E-skin is an integrated electronic system that can mimic the perceptual ability of human skin. Traditional analysis methods struggle to handle complex e-skin data, which include time series and multiple patterns, especially when dealing with intricate signals real-time responses. Recently, deep learning techniques, such as convolutional neural network, recurrent transformer methods, provide effective solutions automatically extract data features recognize significantly improving data. Deep not only capable handling multimodal but also response personalized predictions in dynamic environments. Nevertheless, problems insufficient annotation high demand for computational resources still limit application e-skin. Optimizing algorithms, efficiency, exploring hardware-algorithm co-designing will be key future development. This review aims present techniques applied inspiration subsequent researchers. We first summarize sources characteristics models applicable their applications analysis. Additionally, we discuss use e-skin, particularly health monitoring human-machine interactions, explore current challenges development directions.

Язык: Английский

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Ultrastretchable freezing-tolerant organohydrogels for health monitoring and triboelectric nanogenerator-based gesture recognition

Nano Energy, Год журнала: 2024, Номер unknown, С. 110261 - 110261

Опубликована: Сен. 1, 2024

Язык: Английский

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Hydrogel microrobots for biomedical applications

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Май 22, 2024

Recent years have witnessed a surge in the application of microrobots within medical sector, with hydrogel standing out due to their distinctive advantages. These microrobots, characterized by exceptional biocompatibility, adjustable physico-mechanical attributes, and acute sensitivity biological environments, emerged as pivotal tools advancing applications such targeted drug delivery, wound healing enhancement, bio-imaging, precise surgical interventions. The capability navigate perform tasks complex systems significantly enhances precision, efficiency, safety therapeutic procedures. Firstly, this paper delves into material classification properties compares advantages different materials. Furthermore, it offers comprehensive review principal categories recent innovations synthesis, actuation mechanisms, biomedical hydrogel-based microrobots. Finally, manuscript identifies prevailing obstacles future directions microrobot research, aiming furnish insights that could propel advancements field.

Язык: Английский

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Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(25), С. 6091 - 6101

Опубликована: Янв. 1, 2024

Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis treatment remain a great challenge. The simultaneous inhibition tumor growth is necessary for cancer obtain ideal therapeutic outcomes. We herein report development radioactive hybrid semiconducting polymer nanoparticles (SPNH) imaging-guided tri-modal therapy cancer. Two polymers are used form SPNH with diameter around 60 nm via nano-coprecipitation they also labeled iodine-131 (131I) enhance imaging functions. formed show good radiolabeling stability excellent photodynamic photothermal effects under 808 laser irradiation produce singlet oxygen (1O2) heat. Moreover, can generate 1O2 ultrasound their sonodynamic properties. After intravenous tail vein injection, effectively accumulate in subcutaneous 4T1 tumors living mice as verified fluorescence single photon emission computed tomography (SPECT) imaging. With using an US, mediate (PDT), (PTT) (SDT) kill cells. Such leads improved efficacy inhibiting suppressing compared sole SDT combinational PDT-PTT. This study thus demonstrates applications diagnose combine different therapies effective treatment.

Язык: Английский

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Photoexcited Electro‐Driven Reactive Oxygen Species Channeling for Precise Extraction of Biomarker Information from Tumor Interstitial Fluid

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Direct electrochemical detection of miRNA biomarkers in tumor tissue interstitial fluid (TIF) holds great promise for adjuvant therapy tumors the perioperative period, yet is limited by background interference and weak signal. Herein, a wash-free separation-free biosensor based on photoexcited electro-driven reactive oxygen channeling analysis (LEOCA) developed to solve high-fidelity physiological samples. In presence miRNA, nanoacceptors (ultrasmall-size polydopamine, uPDA) are responsively assembled surface nanodonors (zirconium metal-organic framework, ZrMOF) form core-satellite aggregates. The produced lifetime-constraint singlet upon light irradiation captured catechol constrained uPDA, oxidized quinone immediately electro-reduced at transient collision process electrode, resulting cascade electron transfer amplified current. Thereby, nanosensor exhibits low limit (1.1 fM), high reproducibility (relative standard deviation 2.0%). Compared with quantitative real-time polymerase chain reaction (qRT-PCR), clinical accuracy (area under curve value) significantly increased from 0.75 0.93 distinguishing breast cancer patients healthy donors. This study demonstrates an inspiration synergy between nanodonor/nanoacceptor synchronous electrode bottleneck problem detecting unprocessed samples sample-in-answer-out manner.

Язык: Английский

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In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell exhaustion for post-operative cancer therapy

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159426 - 159426

Опубликована: Янв. 8, 2025

Язык: Английский

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Hydrogel-Based Continuum Soft Robots

Gels, Год журнала: 2025, Номер 11(4), С. 254 - 254

Опубликована: Март 27, 2025

This paper comprehensively reviews the latest advances in hydrogel-based continuum soft robots. Hydrogels exhibit exceptional flexibility and adaptability compared to traditional robots reliant on rigid structures, making them ideal as biomimetic robotic skins platforms for constructing highly accurate, real-time responsive sensory interfaces. The article systematically summarizes recent research developments across several key dimensions, including application domains, fabrication methods, actuator technologies, sensing mechanisms. From an perspective, span healthcare, manufacturing, agriculture. Regarding techniques, extensively explores crosslinking additive microfluidics, other related processes. Additionally, categorizes thoroughly discusses various actuators solute/solvent variations, pH, chemical reactions, temperature, light, magnetic fields, electric hydraulic/electro-osmotic stimuli, humidity. It also details strategies designing implementing diverse sensors, strain, pressure, humidity, conductive, magnetic, thermal, gas, optical, multimodal sensors. Finally, offers in-depth discussion of prospective applications robots, particularly emphasizing their potential medical industrial fields. Concluding remarks include a forward-looking outlook highlighting future challenges promising directions.

Язык: Английский

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The 40th anniversary of the School of Materials Science and Engineering at Southeast University

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

In recent years, one-dimensional (1D) implantable sensors have received considerable attention and rapid development in the biomedical field due to their unique structural characteristics high integration capability. These can be implanted into human body with minimal invasiveness, facilitating real-time accurate monitoring of various physiological pathological parameters. This review examines latest advancements 1D sensors, focusing on material design device integration, implantation methods, construction stable sensor–tissue interface. Furthermore, a comprehensive overview is provided regarding applications future research directions for an ultimate aim promote utilization personalized healthcare precision medicine.

Язык: Английский

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A thermally reversible injectable adhesive for intestinal tissue repair and anti-postoperative adhesion

Biomaterials Science, Год журнала: 2024, Номер 12(12), С. 3141 - 3153

Опубликована: Янв. 1, 2024

Intestine damage is an acute abdominal disease that usually requires emergency sealing. However, traditional surgical suture not only causes secondary to the injured tissue, but also results in adhesion with other tissues cavity. To this end, a thermally reversible injectable gelatin-based hydrogel adhesive (GTPC) constructed by introducing transglutaminase (TGase) and proanthocyanidins (PCs) into gelatin system. By reducing catalytic activity of TGase, density covalent hydrogen bond crosslinking can be regulated tune sol-gel transition temperature hydrogels above physiological (42 °C) without any synthetic small molecules. The GTPC exhibits good tissue adhesion, antioxidant, antibacterial properties, which effectively seal damaged intestinal regulate microenvironment site, promoting repair regeneration. Intriguingly, temperature-induced disruption reformation confer asymmetric preventing when applied vivo. Animal experiment outcomes reveal firmly, accelerate healing, efficiently prevent postoperative adhesion.

Язык: Английский

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