Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 17, 2025
Background
Heart
failure
(HF)
is
a
prevalent
cardiovascular
disease
that
currently
lacks
effective
treatment
options
due
to
its
intricate
pathogenesis.
A
recent
study
has
linked
disulfidoptosis,
novel
form
of
cell
demise,
with
the
development
range
diseases.
Nonetheless,
effect
disulfidoptosis
on
immune
microenvironment
HF
not
well
comprehended.
In
this
paper,
bioinformatics
analysis
was
performed
investigate
how
disulfidptosis-related
genes
(DRGs)
affect
HF.
Methods
The
expression
four
DRGs
initially
examined
using
bulk
RNA-Seq
and
single-cell
RNA
sequencing
data.
predictive
model
subsequently
developed.
Consensus
clustering
used
distinguish
between
two
clusters
DRGs.
these
characteristics
further
explored,
such
as
infiltrating
cells,
response
gene
sets,
HLAs
genes.
Results
All
were
dysregulated
in
samples.
based
effectively
differentiated
patients
healthy
individuals,
which
validated
experiment.
These
strongly
associated
abundance
monocytes.
Moreover,
our
identified
distinct
exhibited
differences
terms
abundance,
response,
HLA
expression.
biological
functions
also
revealed.
Conclusion
Our
discovery
underscores
pivotal
role
shaping
diversity
intricacy
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
519, С. 216109 - 216109
Опубликована: Авг. 1, 2024
Immunotherapy
is
a
promising
strategy
to
inhibit
the
progression
of
solid
tumors.
However,
current
vaccine
adjuvants
represented
by
aluminum
adjuvant
(Alum)
fail
tumor
antigens
initiate
effective
T
cell
immunity.
Despite
efforts
have
been
made
optimize
physical
characteristics
Alum,
lack
specific
immunostimulatory
functions
still
results
in
their
inability
effectively
induce
cytotoxic
immune
responses.
Encouragingly,
an
iterative
layered
double
hydroxide
(LDH)
nano‑aluminum
(NanoAlum)
re-engineered
from
clinical
AlOOH
Alum
and
Mg(OH)2
antacid
has
shown
efficacy
evoking
both
potent
humoral
cellular
Notably,
it
can
also
serve
as
microenvironmental
immunomodulator
reshape
aberrant
physicochemical
attributes
microenvironment.
Interestingly,
highly
flexible
crystal
structure
chemical
composition
offer
variety
LDH-based
candidates
(NanoMAlum)
doping
with
body
essential
nutritional
metal
ions
(M),
which
show
great
potential
amplify
immunotherapy.
In
this
review,
we
summarize
development
progress
LDH
NanoAlum
its
variants
NanoMAlum
for
cancer
By
rethinking
challenges
that
hindered
preclinical/clinical
application,
charted
research
pathway
based
on
engineered
organoids
accelerate
applications
these
NanoMAlums
review.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Modern
radiotherapy
frequently
employs
radiosensitizers
for
radiation
dose
deposition
and
triggers
an
immunomodulatory
effect
to
enhance
tumor
destruction.
However,
developing
glioma‐targeted
sensitizers
remains
challenging
due
the
blood–brain
barrier
(BBB)
multicomponent
instability.
This
study
aims
green‐synthesize
transferrin–bismuth
nanoparticles
(TBNPs)
as
biosafe
X‐ray
absorption
by
tumors
stimulate
immune
response
glioma
therapy.
The
proposed
protein‐based
strategy
provides
TBNPs
with
BBB‐crossing
ability
prevents
off‐target
toxicity.
Cellular
experiments
following
4
Gy
of
irradiation
reveal
that
increase
DNA
damage
in
cells
trigger
immunomodulation,
thereby
inducing
immunogenic
cell
death.
Furthermore,
effectively
inhibit
growth
through
synergistic
immunotherapy
orthotopic
mouse
model.
findings
highlight
promising
effective
immunomodulation.
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Ferroptosis
represents
a
promising
therapeutic
approach
for
breast
cancer
treatment.
However,
cells
can
develop
resistance
through
the
SLC7A11-GSH-GPX4
axis,
wherein
increased
SLC7A11
expression
enhances
cystine
uptake,
replenishes
GSH,
and
reactivates
GPX4.
Notably,
with
high
become
vulnerable
to
disulfidptosis
under
glucose-deprived
conditions.
We
aimed
dual-mode
strategy
that
simultaneously
induces
ferroptosis
by
targeting
both
lipid
peroxidation
glucose
metabolism
in
cells.
Fe-Cu-SS
metal-organic
frameworks
(MOFs)
loaded
BAY876
(FCSP@876
MOFs)
were
synthesized
enhance
trigger
The
MOFs
characterized
using
transmission
electron
microscopy
(TEM),
Fourier-transform
infrared
(FTIR)
spectroscopy,
X-ray
photoelectron
spectroscopy
(XPS),
UV-Vis
spectroscopy.
In
vitro
experiments
demonstrated
FCSP@876
reactive
oxygen
species
(ROS)
levels
while
depleting
NADPH.
Western
blotting
actin
filament
staining
confirmed
underlying
mechanisms.
vivo
xenograft
BALB/c
mice
assessed
synergistic
effects
of
induction.
During
induction,
exhibited
an
adaptive
upregulation
expression.
effectively
counteracted
this
mechanism
inducing
restricting
uptake
BAY876,
leading
NADPH
depletion
subsequent
disulfidptosis.
Both
enhanced
efficacy
compared
single-mode
treatments.
This
study
successfully
developed
novel
combines
MOFs,
offering
overcoming
therapy.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Small
cell
lung
cancer
(SCLC)
is
an
extremely
aggressive
and
highly
malignant
type
of
that
frequently
develops
resistance
recurrence
following
initial
treatment.
Paclitaxel
(PTX)
a
second‐line
therapeutic
option
for
SCLC
patients
with
to
first‐line
However,
its
clinical
application
limited
due
suboptimal
efficacy
the
risk
hypersensitivity
reactions.
To
address
these
challenges,
novel
strategy
employing
cationic
liposome‐based
biomimetic
drug
co‐delivery
system,
siPFKFB4/PRL
PTX
@RBCM‐cRGD,
which
simultaneously
delivers
paclitaxel
PFKFB4‐targeting
small
interfering
RNA
(siRNA)
cells
tissues
proposed.
These
findings
demonstrate
this
system
can
induce
ferroptosis
in
cells,
thereby
enhancing
their
sensitivity
paclitaxel.
Moreover,
It
promotes
infiltration
immune
secretion
cytokines
within
microenvironment,
effectively
activating
anti‐tumor
immunity.
When
combined
anti‐PD‐L1
antibodies,
it
further
potentiates
responses.
results
suggest
codelivery
not
only
induces
enhance
but
also
reprograms
potentiating
effects
immunotherapy
providing
promising
new
SCLC.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 11, 2024
Abstract
Modulating
macrophages
presents
a
promising
avenue
in
tumor
immunotherapy.
However,
cells
have
evolved
mechanisms
to
evade
macrophage
activation
and
phagocytosis.
Herein,
we
introduced
bispecific
antibody-based
nanoengager
facilitate
the
recognition
phagocytosis
of
by
macrophages.
Specifically,
genetically
engineered
two
single
chain
variable
fragments
(scFv)
onto
cell
membrane:
anti-CD40
scFv
for
engaging
with
anti-Claudin18.2
(CLDN18.2)
interacting
cells.
These
nanoengagers
were
further
constructed
coating
scFv-anchored
membrane
into
PLGA
nanoparticle
core.
Our
developed
significantly
boosted
immune
responses,
including
increased
macrophages,
enhanced
antigen
presentation,
elevated
cytotoxic
T
lymphocyte
activity.
combined
benefits
resulted
enhancing
antitumor
efficacy
against
highly
aggressive
“cold”
pancreatic
cancer.
Overall,
this
study
offers
versatile
design
immunotherapy,
achieved
through
engineering
incorporate
antibody-anchored
membrane.
Triple-negative
breast
cancer
(TNBC)
responds
poorly
to
immunotherapy
due
insufficient
immunogenicity
and
highly
immunosuppressive
tumor
microenvironment
(TME).
Herein,
an
intelligent
calcium/cobalt-based
nanomodulator
(Ca,Co)CO
Abstract
Pyroptosis
possesses
potent
antitumor
immune
activity,
making
pyroptosis
inducer
development
a
promising
direction
for
tumor
immunotherapy.
Persistent
luminescence
nanoparticles
(PLNPs)
are
highly
sensitive
optical
probes
extensively
employed
in
diagnosis
and
therapy.
However,
based
on
PLNPs
has
not
been
reported
yet.
Herein,
polyethylene
glycol–poly
lactic
acid‐co‐glycolic
acid
(PEG–PLGA:
PP)
modified
biodegradable
CaS:Eu
2+
(CSE@PP)
synthesized
as
immunotherapy
the
first
time.
The
CSE@PP
biowindow
persistent
(PersL)
pH‐responsive
degradation
properties,
allowing
it
to
remain
stable
under
neutral
pH
but
degrade
when
exposed
weak
(pH
<
6.5).
During
within
tumor,
constantly
releases
H
2
S
Ca
while
its
PersL
gradually
fades
away.
Thus,
signal
can
self‐monitor
release.
Furthermore,
released
result
mitochondrial
dysfunction
inactivation
of
reactive
oxygen
species
scavenging
enzymes,
synergistic
facilitating
intracellular
oxidative
stress,
which
induces
caspase‐1/GSDM‐D
dependent
subsequent
responses.
In
word,
is
confirmed
that
release
pyroptosis‐mediated
Immunotherapy.
This
work
will
facilitate
biomedical
applications
inspire
pyroptosis‐induced
