Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

и другие.

ACS Materials Au, Год журнала: 2024, Номер 5(1), С. 115 - 140

Опубликована: Ноя. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Язык: Английский

Bioinspired Adhesives with Debonding-on-Demand Capability DOI
Athanasios Skandalis, Mathieu A. Ayer, Christoph Weder

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 420 - 427

Опубликована: Март 18, 2025

Adhesives with debonding-on-demand (DoD) capability can simplify and improve manufacturing processes, extend the life cycle of products, facilitate recycling, thus attracting fast-growing interest for use in different sectors. A general design approach DoD adhesives is based on supramolecular polymers, which be disassembled by an external stimulus, allowing modification physical properties these materials. However, adhesive strength generally limited to a few megapascals, their synthesis often quite involved. Here, we report that problems overcome family were inspired structure function natural resin shellac. These are linear oligomers bisphenol diglycidyl ether secondary diamines have, despite widespread cross-linked epoxy thermosets, remained unexplored far. We show if molecular weight limited, highly soluble melt-processable produced. Adhesion tests performed lap joints made stainless steel substrates reveal shear 3.5-16 MPa, upper limit this range exceeds bond shellac blueprint many previous adhesives. demonstrate debonding upon heating above glass transition temperature readily possible broken easily rebond without any loss strength.

Язык: Английский

Процитировано

0
Local delivery of MoS2/FeS2 heterojunction by biomolecular microneedles for multimodal therapy of infected wounds DOI

Wenjie You,

Zichao Cai,

Feng Xiao

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155722 - 155722

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

3
Stretchable and body conformable electronics for emerging wearable therapies DOI Creative Commons

Benzhao Huang,

Qian Wang, Wei Li

и другие.

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

Abstract Wearable therapy represents a research frontier where material science, electrical engineering, and medical disciplines intersect, offering significant potential for remote portable healthcare. Unlike conventional approaches that rely on rigid materials, the ability to stretch is crucial therapeutic devices achieve enhanced mechanical adaptability. Moreover, conformable integration of these into body pivotal in establishing reliable interfaces long‐term treatment. These emerging provide an attractive platform developing new protocols do not disrupt daily activities. This review comprehensively overviews recent progress stretchable body‐conformable electronics wearable applications. The discussion begins with design fabrication through structural designs innovation. mechanisms adopted by are then systematically explored. Furthermore, article delineates characteristics devices, such as biocompatibility, secure skin attachment, effective moisture management. poised inspire innovative device treatment future technology.

Язык: Английский

Процитировано

2
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

и другие.

ACS Materials Au, Год журнала: 2024, Номер 5(1), С. 115 - 140

Опубликована: Ноя. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Язык: Английский

Процитировано

0