Abstract
Low‐temperature
second
near‐infrared
region
(NIR‐II)
photothermal
therapy
(PTT)
has
shown
significant
potential
in
minimizing
damage
to
normal
tissues
and
reducing
inflammation.
However,
it
still
faces
challenge
of
insufficient
immune
response.
Thus,
a
multifunctional
phototheranostic
nanoparticle
(BDPB/Pt/Fe@P[5])
is
developed
by
co‐loading
BDPB,
CDHPt,
Fe
2
⁺
with
pH‐sensitive
lipid
DSPE‐PEOz2K.
The
carboxylatopillar[5]arene
(CP[5])
used
construct
this
exhibits
strong
host–guest
recognition
pyridine
salts,
alleviating
aggregation
caused
quench
(ACQ)
effect
enhancing
the
NIR‐II
emission
donor–acceptor–donor
(D–A–D)‐type
organic
small
molecule
(BDPB).
CP[5]
provides
suitable
vehicles
for
encapsulating
platinum
(IV)
prodrugs
(CDHPt)
ions
via
metal
coordination
controllable
reactive
oxygen
species
(ROS)
release.
Under
low‐intensity
laser
irradiation
an
acidic
tumor
microenvironment,
nanoparticles
degrade,
releasing
CDHPt
platinum‐based
chemodynamic
(CDT).
facilitates
direct
production
superoxide
anions
(O₂·⁻)
from
O₂
partially
converts
into
highly
cytotoxic
hydroxyl
radicals,
thereby
promoting
Fenton
reaction
process.
therapeutic
efficacy
further
synergized
immunogenic
cell
death
(ICD)
effect.
Abstract
Bacterial
therapy
is
recognized
as
a
cost‐effective
treatment
for
several
diseases.
However,
its
development
hindered
by
limited
functionality,
weak
inherent
therapeutic
effects,
and
vulnerability
to
harsh
microenvironmental
conditions,
leading
suboptimal
activity.
Enhancing
bacterial
activity
outcomes
emerges
pivotal
challenge.
Nanozymes
have
garnered
significant
attention
due
their
enzyme‐mimic
activities
high
stability.
They
enable
bacteria
mimic
the
functions
of
gene‐edited
expressing
same
functional
enzymes,
thereby
improving
efficacy.
This
review
delineates
mechanisms
nanozymes,
followed
summary
strategies
preparing
bacteria/nanozyme
composites.
Additionally,
synergistic
effects
such
composites
in
biomedical
applications
gastrointestinal
diseases
tumors
are
highlighted.
Finally,
challenges
discussed
propose
potential
solutions.
study
aims
provide
valuable
insights
offer
theoretical
guidance
advancement
nanomaterial‐assisted
therapy.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Abstract
Arsenic
agents
have
shown
great
potential
in
fighting
leukemia,
but
are
poorly
known
treating
solid
tumors,
mainly
ascribing
to
the
rapid
clearance
and
low
targeting
ability.
It
is
reported
that
morphology
modulation
can
enhance
interaction
between
nanoparticles
cell
membrane.
Herein,
a
dismountable
protein
corona‐modified
virus‐like
manganese‐arsenic
nanomedicine
(vMnAs@HR)
rationally
proposed
for
realizing
safe
targeted
delivery
synergistic
arsenotherapy.
The
nanoparticle
(vMnAs)
constructed
followed
by
modification
of
temporary
R848‐loaded
HDL
(HR)
corona.
Upon
intravenous
injection,
HR
corona
stable
actively
tumor
tissue
taking
advantage
its
receptor
SR‐BI.
Intriguingly,
upon
accumulated
tumor,
be
jettisoned
interacted
with
macrophages
proinflammatory
phenotype
modulation.
re‐exposed
vMnAs
efficiently
endocytosis
designed
spiky
morphology.
Moreover,
released
double‐stranded
DNA
(dsDNA)
manganese
ions
during
apoptosis
cooperatively
activate
cyclic
guanosine
monophosphate
adenosine
synthase
(cGAS)‐stimulator
interferon
genes
(STING)
signaling
pathway
DCs
systematic
immune
activation.
anticipated
this
morphology‐transformable
realize
efficient
arsenic
cGAS-STING
pathway
activation
has
attracted
considerable
attention
in
antitumor
immunotherapy,
but
clinical
outcomes
lag
behind
expectations
due
to
overlooked
negative
feedback
mechanisms.
Here,
we
determine
that
STING
promotes
tumor
stemness,
which
weakens
the
efficacy
of
STING-based
therapies,
presenting
a
double-edged
sword.
To
address
this
therapeutic
paradox,
simple
metal-phenolic
polymeric
micelle
(HMQ)
was
developed,
Mn2+
(a
agonist)
is
coordinated
with
quercetin
stemness
inhibitor)
and
hyaluronic
acid
(HA),
unlock
full
potential
pathway.
This
unique
coordination
structure
integrates
active
targeting
rapid
pH-responsive
drug
release.
Importantly,
released
drugs
remained
their
original
form,
avoiding
changes
bioactivity.
HMQ
effectively
mitigates
stemness-promoting
effects
activation,
thus
significantly
amplifying
potency
cGAS-STING-based
therapies.
intelligent
facile
establishes
new
generation
agonists
promising
translatability
provides
flexible
platform
for
win–win
strategy.
The
diagnosis
and
treatment
of
non-small
cell
lung
cancer
in
clinical
settings
face
serious
challenges,
particularly
due
to
the
lack
integration
between
two
processes,
which
limit
real-time
adjustments
plans
based
on
patient's
condition
drive-up
costs.
Here,
we
present
a
multifunctional
pH-sensitive
core-shell
nanoparticle
containing
quercetin
(QCT),
termed
AHA@MnP/QCT
NPs,
designed
for
simultaneous
cancer.
Mechanistic
studies
indicated
that
QCT
Mn2+
exhibited
excellent
peroxidase-like
(POD-like)
activity,
catalysing
conversion
endogenous
hydrogen
peroxide
into
highly
toxic
hydroxyl
radicals
through
Fenton-like
reaction,
depleting
glutathione
(GSH),
promoting
reactive
oxygen
species
(ROS)
generation
mitochondria
endoplasmic
reticulum,
inducing
ferroptosis.
Additionally,
could
activate
cGAS-STING
signalling
pathway
promote
maturation
dendritic
cells
infiltration
activated
T
cells,
thus
tumor
immunogenic
death
(ICD).
Furthermore,
it
effective
T2-weighted
MRI
enhancement
imaging,
making
them
valuable
diagnosis.
In
vitro
vivo
experiments
demonstrated
NPs
enabled
non-invasive
imaging
treatment,
presented
one-stone-for-two-birds
strategy
combining
with
broad
potential
application
therapy.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
The
immunomodulatory
effect
of
the
interferon
gene‐stimulating
factor
(STING)
pathway
makes
it
an
important
target
for
tumor
immunotherapy,
which,
however,
suffers
from
easy
degradation
and
deteriorated
stimulatory
capacity
current
STING
agonists
in
solid
microenvironment.
Herein,
a
nanocomposite
medicine，
MLAP，
is
constructed
by
intercalating
agonist
ADU‐S100
into
Mn‐doped
layered
double
hydroxide,
which
capable
modulating
immune
microenvironment
tumors
to
enhance
activation.
Importantly,
intercalation
interlayer
structure
enhances
intracellular
permeability
agonists,
meanwhile,
activation
amplified
sensitizing
Mn
2+
.
In
addition,
moderate
alkalinity
MLAP
neutralizes
acidity
catalyzes
decomposition
hydrogen
peroxide
produce
oxygen,
rectifying
acidic
hypoxia
immunosuppressive
thus
strengthening
efficacy
agonists.
This
work
provides
excellent
carrier
not
only
improves
bioavailability
but
also
remodels
boosted
immunotherapy.
