Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Sepsis
presents
a
significant
medical
challenge
due
to
its
intense
inflammatory
response
infection,
often
resulting
in
high
mortality
rates.
A
promising
therapeutic
strategy
targets
the
cholinergic
anti-inflammatory
pathway
(CAIP),
which
regulates
immune
responses.
This
study
investigates
ingestion
of
piezoelectric
particles
that
adhere
stomach
lining,
specifically
targeting
TRPV1
receptors.
In
mouse
model
sepsis,
these
particles,
when
activated
by
low-intensity
pulsed
ultrasound,
generate
mild
electrical
pulses.
These
pulses
stimulate
vagal
afferent
fibers,
transmitting
signals
brain
and
modulating
neural-immune
network
via
CAIP.
Consequently,
this
leads
reduction
systemic
inflammation,
mitigating
weight
loss,
alleviating
multiple
tissue
injuries,
preventing
death
cells
spleen.
approach
addresses
critical
need
for
noninvasive
sepsis
therapies,
potentially
improving
patient
outcomes.
Utilizing
portable
ultrasound
equipment
with
minimal
thermal
effects,
technique
offers
safe
convenient
treatment
option,
even
home
use.
Язык: Английский
Force-Electric Biomaterials and Devices for Regenerative Medicine
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123288 - 123288
Опубликована: Март 1, 2025
Язык: Английский
Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Abstract
With
the
integration
of
bioelectronics
and
materials
science,
implantable
self‐powered
systems
for
electrical
stimulation
medical
devices
have
emerged
as
an
innovative
therapeutic
approach,
garnering
significant
attention
in
research.
These
achieve
self‐powering
through
integrated
energy
conversion
modules,
such
triboelectric
nanogenerators
(TENGs)
piezoelectric
(PENGs),
significantly
enhancing
portability
long‐term
efficacy
equipment.
This
review
delves
into
design
strategies
clinical
applications
systems,
encompassing
optimization
harvesting
selection
fabrication
adaptable
electrode
materials,
innovations
systematic
strategies,
extensive
utilization
biological
therapies,
including
treatment
neurological
disorders,
tissue
regeneration
engineering,
drug
delivery,
tumor
therapy.
Through
a
comprehensive
analysis
latest
research
progress,
technical
challenges,
future
directions
these
areas,
this
paper
aims
to
provide
valuable
insights
inspiration
further
systems.
Язык: Английский
Emerging Piezoelectric Metamaterials for Biomedical Applications
Опубликована: Ноя. 21, 2024
Emerging
piezoelectric
metamaterials
hold
immense
promise
for
biomedical
applications
by
merging
the
intrinsic
electrical
properties
of
piezoelectricity
with
precise
architecture
metamaterials.
This
review
provides
a
comprehensive
overview
various
materials-
such
as
molecular
crystals,
ceramics,
and
polymers-known
their
exceptional
performance
biocompatibility.
We
explore
advanced
engineering
approaches,
including
design,
supramolecular
packing,
3D
assembly,
which
enable
customization
targeted
applications.
Particular
attention
is
given
to
pivotal
role
metamaterial
structuring
in
development
0D
spheres,
1D
fibers
tubes,
2D
films,
scaffolds.
Key
applications,
tissue
engineering,
drug
delivery,
wound
healing,
biosensing,
are
discussed
through
illustrative
examples.
Finally,
article
addresses
critical
challenges
future
directions,
aiming
drive
further
innovations
biomaterials
next-generation
healthcare
technologies.
Язык: Английский
The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(42), С. 56730 - 56743
Опубликована: Окт. 12, 2024
Electrical
stimulation
has
been
used
clinically
as
an
adjunct
therapy
to
accelerate
the
healing
of
bone
defects,
and
its
mechanism
requires
further
investigations.
The
complexity
physiological
microenvironment
makes
it
challenging
study
effect
electrical
signal
on
cells
alone.
Therefore,
artificial
system
mimicking
cell
in
vitro
was
developed
address
this
issue.
In
work,
a
novel
constructed
based
polypyrrole
nanowires
(ppyNWs)
with
high
aspect
ratio.
Synthesized
ppyNWs
formed
conductive
network
composited
hydrogel
which
contained
modified
gelatin
methacrylate,
providing
culture
matrix
for
marrow
mesenchymal
stem
cells.
dual-network
had
improved
mechanical,
electrical,
hydrophilic
properties.
It
able
imitate
three-dimensional
structure
allowed
adjustable
stimulations
following
system.
This
integrated
plates,
platinum
electrodes,
copper
wires,
external
power
sources
construct
optimum
voltage
determined
be
2
V,
exhibited
remarkable
biocompatibility.
Moreover,
significant
promotion
spreading,
osteogenic
makers,
bone-related
gene
expression
RNA-seq
analysis
revealed
that
osteogenesis
correlated
Notch,
BMP/Smad,
calcium
pathways.
proven
biomimetic
could
regulate
procedure,
provided
information
about
how
regulates
differentiations.
Язык: Английский
Nanomaterial‐Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications
Advanced Materials Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Abstract
Transient
receptor
potential
vanilloid
subtype
1
(TRPV1)
is
a
nonselective
cation
channel
involved
in
various
physiological
processes
such
as
pain
perception,
thermoregulation,
and
inflammatory
responses.
Nanomaterials
have
emerged
precise
tools
to
modulate
TRPV1
activity,
offering
high
spatiotemporal
resolution
specificity.
These
nanomaterials
act
transducers,
responding
internal
or
external
stimuli
pH,
light,
electric,
magnetic
fields
deliver
modulatory
agents
like
agonists,
antagonists,
heat,
reactive
species,
mechanical
forces
channels.
This
strategy
enables
non‐invasive
targeted
therapeutic
interventions
for
diseases
associated
with
dysfunction.
In
this
review,
recent
advances
are
highlighted
nanomaterial‐mediated
modulation
its
biomedical
applications.
The
structure
activation
mechanisms,
the
integration
of
effective
modulation,
required
material
properties
covered.
Moreover,
applications
discussed,
including
neurostimulation,
neurological
disorder
therapies,
cancer
metabolic
disease
treatments,
cardiovascular
interventions.
Future
research
directions
challenges
field
also
proposed.
Язык: Английский