Nanomaterial‐Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications DOI

Peng Pei,

Yafei Du,

Jiong‐Wei Wang

и другие.

Advanced Materials Technologies, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Abstract Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cation channel involved in various physiological processes such as pain perception, thermoregulation, and inflammatory responses. Nanomaterials have emerged precise tools to modulate TRPV1 activity, offering high spatiotemporal resolution specificity. These nanomaterials act transducers, responding internal or external stimuli pH, light, electric, magnetic fields deliver modulatory agents like agonists, antagonists, heat, reactive species, mechanical forces channels. This strategy enables non‐invasive targeted therapeutic interventions for diseases associated with dysfunction. In this review, recent advances are highlighted nanomaterial‐mediated modulation its biomedical applications. The structure activation mechanisms, the integration of effective modulation, required material properties covered. Moreover, applications discussed, including neurostimulation, neurological disorder therapies, cancer metabolic disease treatments, cardiovascular interventions. Future research directions challenges field also proposed.

Язык: Английский

Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy DOI Creative Commons

Cam‐Hoa Mac,

Giang Le Thi Nguyen,

Duy Tân Nguyên

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Sepsis presents a significant medical challenge due to its intense inflammatory response infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates ingestion of piezoelectric particles that adhere stomach lining, specifically targeting TRPV1 receptors. In mouse model sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals brain and modulating neural-immune network via CAIP. Consequently, this leads reduction systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries, preventing death cells spleen. approach addresses critical need for noninvasive sepsis therapies, potentially improving patient outcomes. Utilizing portable ultrasound equipment with minimal thermal effects, technique offers safe convenient treatment option, even home use.

Язык: Английский

Процитировано

0

Force-Electric Biomaterials and Devices for Regenerative Medicine DOI

Shuncheng Yao,

Xi Cui, Yong Zhang

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123288 - 123288

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices DOI Creative Commons
Xi Cui, Li Wu, Yong Zhang

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract With the integration of bioelectronics and materials science, implantable self‐powered systems for electrical stimulation medical devices have emerged as an innovative therapeutic approach, garnering significant attention in research. These achieve self‐powering through integrated energy conversion modules, such triboelectric nanogenerators (TENGs) piezoelectric (PENGs), significantly enhancing portability long‐term efficacy equipment. This review delves into design strategies clinical applications systems, encompassing optimization harvesting selection fabrication adaptable electrode materials, innovations systematic strategies, extensive utilization biological therapies, including treatment neurological disorders, tissue regeneration engineering, drug delivery, tumor therapy. Through a comprehensive analysis latest research progress, technical challenges, future directions these areas, this paper aims to provide valuable insights inspiration further systems.

Язык: Английский

Процитировано

3

Emerging Piezoelectric Metamaterials for Biomedical Applications DOI Creative Commons

Zishuo Yan,

Huy Quang Tran, Dongxin Ma

и другие.

Опубликована: Ноя. 21, 2024

Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.

Язык: Английский

Процитировано

3

The Biomimetic Electrical Stimulation System Inducing Osteogenic Differentiations of BMSCs DOI
Zengzilu Xia, H X Zhang, Qing Li

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(42), С. 56730 - 56743

Опубликована: Окт. 12, 2024

Electrical stimulation has been used clinically as an adjunct therapy to accelerate the healing of bone defects, and its mechanism requires further investigations. The complexity physiological microenvironment makes it challenging study effect electrical signal on cells alone. Therefore, artificial system mimicking cell in vitro was developed address this issue. In work, a novel constructed based polypyrrole nanowires (ppyNWs) with high aspect ratio. Synthesized ppyNWs formed conductive network composited hydrogel which contained modified gelatin methacrylate, providing culture matrix for marrow mesenchymal stem cells. dual-network had improved mechanical, electrical, hydrophilic properties. It able imitate three-dimensional structure allowed adjustable stimulations following system. This integrated plates, platinum electrodes, copper wires, external power sources construct optimum voltage determined be 2 V, exhibited remarkable biocompatibility. Moreover, significant promotion spreading, osteogenic makers, bone-related gene expression RNA-seq analysis revealed that osteogenesis correlated Notch, BMP/Smad, calcium pathways. proven biomimetic could regulate procedure, provided information about how regulates differentiations.

Язык: Английский

Процитировано

2

Nanomaterial‐Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications DOI

Peng Pei,

Yafei Du,

Jiong‐Wei Wang

и другие.

Advanced Materials Technologies, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Abstract Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cation channel involved in various physiological processes such as pain perception, thermoregulation, and inflammatory responses. Nanomaterials have emerged precise tools to modulate TRPV1 activity, offering high spatiotemporal resolution specificity. These nanomaterials act transducers, responding internal or external stimuli pH, light, electric, magnetic fields deliver modulatory agents like agonists, antagonists, heat, reactive species, mechanical forces channels. This strategy enables non‐invasive targeted therapeutic interventions for diseases associated with dysfunction. In this review, recent advances are highlighted nanomaterial‐mediated modulation its biomedical applications. The structure activation mechanisms, the integration of effective modulation, required material properties covered. Moreover, applications discussed, including neurostimulation, neurological disorder therapies, cancer metabolic disease treatments, cardiovascular interventions. Future research directions challenges field also proposed.

Язык: Английский

Процитировано

0