Ligand Inter‐Relation Analysis Via Graph Theory Predicts Macrophage Response DOI Open Access
Nayeon Kang, Jangsun Hwang, Daun Jeong

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Abstract Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic structure extracellular matrix can predict cell‐material interactions but not yet demonstrated. In this study, graph theory‐based mathematical modeling RGD ligand inter‐relation is demonstrated by differentially cutting off RGD‐to‐RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) tunable aspect ratio. The are less effectively cut MNBs a lower ratio, which decreases shortest path while increasing number instances thereof, thereby augmenting nano inter‐relation. This facilitates integrin recruitment macrophages thus actin fiber assembly vinculin expression, mediates pro‐regenerative polarization, involving myosin II, polymerization, rho‐associated protein kinase. Unidirectional pre‐aligning or reversibly lifting highly elongated both increase inter‐relation, promotes host macrophage adhesion switches their polarization from pro‐inflammatory phenotype. latter approach produces nano‐spaces through penetrate establish links thereunder. Using theory, study presents example mathematically functionality extracellular‐matrix‐mimetic help elucidate dynamics occurring between cells materials via versatile geometrical nano‐engineering.

Язык: Английский

Automated Magnetic Microrobot Control: From Mathematical Modeling to Machine Learning DOI Creative Commons

Yamei Li,

Yingxin Huo, Xiangyu Chu

и другие.

Mathematics, Год журнала: 2024, Номер 12(14), С. 2180 - 2180

Опубликована: Июль 11, 2024

Microscale robotics has emerged as a transformative field, offering unparalleled opportunities for innovation and advancement in various fields. Owing to the distinctive benefits of wireless operation heightened level safety, magnetic actuation widely adopted technique field microrobotics. However, factors such Brownian motion, fluid dynamic flows, nonlinear forces introduce uncertainties motion micro/nanoscale robots, making it challenging achieve precise navigational control complex environments. This paper presents an extensive review encompassing trajectory from theoretical foundations generation modeling fields well field-actuation methods microrobots. We traditional learning-based approaches robotic systems at micro/nanoscale, then these are compared. Unlike conventional navigation based on mathematical models, can directly learn signals data without relying models. endows micro/nanorobots with high adaptability environments whose models difficult/impossible obtain. hope that this provide insights guidance researchers interested automated microrobot control.

Язык: Английский

Процитировано

4

A double-loop robust position and speed control of an electromagnetic actuator against nonlinear model uncertainties DOI
Han-Sol Lee, Yeongoh Ko, Juhoon Back

и другие.

Control Engineering Practice, Год журнала: 2025, Номер 160, С. 106318 - 106318

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

0

Untethered subcentimeter flying robots DOI Creative Commons
Fanping Sui, Wei Yue, Kamyar Behrouzi

и другие.

Science Advances, Год журнала: 2025, Номер 11(13)

Опубликована: Март 28, 2025

The miniaturization of insect-scale flying robots with untethered flights is extremely challenging as the tradeoff between mass and power becomes problematic. Here, a subcentimeter rotating-wing robot 21 mg in weight 9.4 mm wingspan driven by single-axis alternating magnetic field has accomplished navigable flights. This artificial lightest smallest to realize controllable aerial travels including hovering, collision recovery, route adjustments. Experimentally, it achieved high aerodynamic efficacy measured lift-to-drag ratio 0.7 lift–to–flying 7.2 × 10 −2 N/W at Reynolds number ~2500. wireless driving mechanism, system operation principle, flight characteristics can be further optimized for advancement scale robots.

Язык: Английский

Процитировано

0

Regulating the Azo‐Functionalization of Covalent Organic Frameworks for Photo‐Modulated Adsorption and Sensing of Aniline DOI
Xiaoqin Shen, Bing Yan

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Abstract Photoresponsive materials have garnered considerable attention, particularly azo‐functionalized covalent organic frameworks (COFs), due to their unique ability undergo cis/trans isomerization under UV/visible light irradiation, making them highly promising in the field of adsorption. In this work, innovative post‐synthetic modification (PSM) approach is developed introduce azobenzene groups, resulting construction three COFs with varying degrees azo‐functionalization (ThTFB‐nN = N, n 1, 2, 3). It found that ThTFB‐nN N exhibits reversible alternating irradiation 365 and 450 nm light, degree azo content within framework, as well trans ‐ cis isomerization, can significantly influence material's properties. Notably, ‐ThTFB‐3N demonstrates highest adsorption capacity for aniline at 303.3 mg·g −1 , representing a nearly tenfold enhancement compared (30.7 ). Additionally, ThTFB‐3N shows excellent fluorescence detection capability aniline, achieving limit 22 ppb. To investigate underlying mechanisms detection, density functional theory (DFT) calculations are conducted. conclusion, work introduces novel PSM strategy incorporating photoresponsive units, leading multifunctional material substantial potential detection.

Язык: Английский

Процитировано

0

Teleoperated Magnetic Endoscopy: A Case Study and Perspective DOI Creative Commons
Alexandre Mesot, Michelle Mattille, Quentin Boehler

и другие.

Advanced Intelligent Systems, Год журнала: 2024, Номер unknown

Опубликована: Авг. 18, 2024

Teleoperated robotic surgery is a rapidly growing field that promises to overcome geographical barriers and share expertise over long distances for variety of minimally invasive procedures. A particularly promising technology teleoperation magnetic navigation. In contrast conventional surgical robots, navigation system generates external fields safely dexterously steer soft devices within the human body, enabling versatile, economical, accessible telesurgery platform This perspective highlights recent research efforts in platforms their translation clinical settings context endoscopic discussion supported by case study performed at Multi‐Scale Medical Robotics Center Hong Kong, where an vivo gastroscopy porcine model tandem with two operators, alternating between clinician controlling procedure from operating room Kong remote expert operator console Zurich. The achievements challenges this highlight capabilities future potential telesurgery.

Язык: Английский

Процитировано

2

Nanozyme‐Shelled Microcapsules for Targeting Biofilm Infections in Confined Spaces DOI Creative Commons
Hong‐Huy Tran,

Nadasinee Jaruchotiratanasakul,

Zhenting Xiang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Bacterial infections in irregular and branched confinements pose significant therapeutic challenges. Despite their high antimicrobial efficacy, enzyme‐mimicking nanoparticles (nanozymes) face difficulties achieving localized catalysis at distant infection sites within confined spaces. Incorporating nanozymes into microrobots enables the delivery of catalytic agents to hard‐to‐reach areas, but poor nanoparticle dispersibility distribution during fabrication hinder performance. To address these challenges, a nanozyme‐shelled microrobotic platform is introduced using magnetic microcapsules with collective adaptive mobility for automated navigation complex confinements. Using double emulsions produced from microfluidics as templates, iron oxide silica are assembled 100‐µm microcapsules, which self‐organize multi‐unit, millimeter‐size assemblies under rotating fields. These exhibit peroxidase‐like activity, efficiently catalyzing hydrogen peroxide generate reactive oxygen species (ROS). Notably, microcapsule display remarkable arched confinements, reaching targeted apical regions tooth canal accuracy. Furthermore, perform rapid situ effectively kill biofilms on contact via ROS generation, enabling antibiofilm action. This study demonstrates facile method integrating onto versatile current needs microenvironments.

Язык: Английский

Процитировано

1

The Design of Endovascugular Robots for Cardiac Interventions: A Survey DOI
Natalia M. Alekseeva,

Alexander G. Viller,

Alexey M. Romanov

и другие.

Journal of Field Robotics, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

ABSTRACT The paper presents a survey of modern robots for percutaneous coronary interventions. It covers papers published before October 2024. robotic systems introduced in these are compared by their design, tool manipulation principles, surgical tools compatibility, and human–machine interfaces, including types feedback. provides an overview all main design approaches ever implemented intervention robotics critically analyzes pros cons. 62 endovascular (11 commercial 51 academic) 23 tools, making it the most representative to date best our knowledge. All solutions have been at least as prototypes, while some them tested vivo even reached clinical practice. In discussion section, we analyze known field experience with use CorPath GRX (one popular currently used several hospitals around world), discuss reasons insufficient spread surgery propose vision changing this trend. This is intended primarily engineers designing new medical systems. However, will also be interest surgeons help better understand trade‐offs both products already market promising that available future.

Язык: Английский

Процитировано

1

Magnetic Torque‐Driven All‐Terrain Microrobots DOI
Qiong Wang, Zhuhua Zhang,

WU Yu-hua

и другие.

Small, Год журнала: 2024, Номер 20(48)

Опубликована: Сен. 10, 2024

Abstract All‐terrain microrobots possess significant potential in modern medical applications due to their superior maneuverability complex terrains and confined spaces. However, conventional often struggle with adaptability operational difficulties variable environments. This study introduces a magnetic torque‐driven all‐terrain multiped microrobot (MTMR) address these challenges. By coupling the structure's multiple symmetries different uniform fields, such as rotating oscillating MTMR demonstrates various locomotion modes, including rolling, tumbling, walking, jumping, combinations. Experimental results indicate that robot can navigate diverse terrains, flat surfaces, steep slopes (up 75°), gaps over twice its body height. Additionally, performs well spaces, capable of passing through slits (0.1 length) low tunnels (0.25 length). The shows for clinical like minimally invasive hemostasis internal bleeding thrombus removal from blood vessels accurate cargo manipulation capability. Moreover, carry temperature sensors monitor environmental changes real time while simultaneously manipulating objects, displaying in‐situ sensing parallel task implementation. technology notable versatility, providing solid foundation practical interventional medicine.

Язык: Английский

Процитировано

0

Ligand Inter‐Relation Analysis Via Graph Theory Predicts Macrophage Response DOI Open Access
Nayeon Kang, Jangsun Hwang, Daun Jeong

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Abstract Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic structure extracellular matrix can predict cell‐material interactions but not yet demonstrated. In this study, graph theory‐based mathematical modeling RGD ligand inter‐relation is demonstrated by differentially cutting off RGD‐to‐RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) tunable aspect ratio. The are less effectively cut MNBs a lower ratio, which decreases shortest path while increasing number instances thereof, thereby augmenting nano inter‐relation. This facilitates integrin recruitment macrophages thus actin fiber assembly vinculin expression, mediates pro‐regenerative polarization, involving myosin II, polymerization, rho‐associated protein kinase. Unidirectional pre‐aligning or reversibly lifting highly elongated both increase inter‐relation, promotes host macrophage adhesion switches their polarization from pro‐inflammatory phenotype. latter approach produces nano‐spaces through penetrate establish links thereunder. Using theory, study presents example mathematically functionality extracellular‐matrix‐mimetic help elucidate dynamics occurring between cells materials via versatile geometrical nano‐engineering.

Язык: Английский

Процитировано

0