Self-assembling chemodrug fiber-hydrogel for transarterial chemoembolization and radiotherapy-enhanced antitumor immunity
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 1 - 16
Опубликована: Фев. 3, 2025
Язык: Английский
Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Март 6, 2024
Percutaneous
thermotherapy,
a
minimally
invasive
operational
procedure,
is
employed
in
the
ablation
of
deep
tumor
lesions
by
means
target-delivering
heat.
Conventional
thermal
methods,
such
as
radiofrequency
or
microwave
ablation,
to
certain
extent,
are
subjected
extended
time
well
biosafety
risks
unwanted
overheating.
Given
its
effectiveness
and
safety,
percutaneous
thermotherapy
gains
fresh
perspective,
thanks
magnetic
hyperthermia.
In
this
respect,
an
injectable-
magnetic-hydrogel-construct-based
agent
likely
be
candidate
for
aforementioned
clinical
translation.
Adopting
simple
environment-friendly
strategy,
colloidal
hydrogel
injection
introduced
binary
system
comprising
super-paramagnetic
Fe
Язык: Английский
H2O2‐Generating Advanced Nanomaterials for Cancer Treatment
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Tumor
cells
exploit
abnormal
redox
homeostasis
and
the
pro‐tumorigenic
effect
of
reactive
oxygen
species
(ROS)
to
enhance
their
survival
progression.
However,
excessively
high
levels
ROS
can
exceed
oxidative
stress
threshold
tumor
cells,
inducing
cell
death.
This
occur
by
selectively
elevating
concentration
H
2
O
in
through
both
endogenous
exogenous
mechanisms.
The
generated
serves
as
a
precursor
for
toxic
ROS,
such
•
OH
1
,
via
chemodynamic
photodynamic
therapy,
respectively,
leading
apoptosis,
necrosis,
ferroptosis.
Strategies
boost
include
direct
delivery
amplifying
generation
inhibiting
antioxidant
enzymes,
leveraging
glucose
oxidase,
employing
photocatalytic
therapy
(PCT),
utilizing
metal
peroxides.
Among
them,
peroxides
have
displayed
remarkable
performance
due
excellent
potential
elevate
within
while
simultaneously
normalizing
acidic
hypoxic
conditions
microenvironment
(TME).
Moreover,
these
nanostructures
sensitivity
complementary
treatments,
like
chemotherapy.
review
summarizes
advanced
perspectives
design,
synthesis,
comparative
analysis
‐generating
nanoplatforms,
emphasizing
capacity
treat
various
cancers.
Язык: Английский
Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
517, С. 215969 - 215969
Опубликована: Июнь 10, 2024
Язык: Английский
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma
Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Precise Regulation of Reactive Oxygen Species in Tumor Microenvironment for Alleviating Inhibitory Immunogenic Cell Death
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Авг. 7, 2024
High
level
of
reactive
oxygen
species
(ROS)
within
the
tumor
microenvironment
(TME)
not
only
damage
cells
but
also
diminish
efficacy
immunogenic
cell
death
(ICD)
and
activity
tumor-infiltrating
T
lymphocytes,
thereby
limiting
effectiveness
immunotherapy.
Therefore,
precise
modulation
ROS
is
crucial
to
effectively
eliminate
activate
ICD-induced
Here,
an
intelligent
yolk
shell
nanoplatform
(SPCCM)
that
features
calcium
carbonate
shells
capable
decomposing
under
acidic
TME
conditions,
releasing
natural
antioxidant
proanthocyanidins
(PAs)
photosensitizer
Ce6
designed.
PAs
scavenge
tumors,
extending
survival
time
while
Ce6,
as
ICD
inducer,
generates
high
concentrations
upon
laser
irradiation,
thus
reaching
toxic
threshold
inducing
apoptosis.
The
resulting
apoptotic
serve
tumor-associated
antigens,
promoting
dendritic
(DCs)
maturation,
activating
ICD.
By
neutralizing
in
TME,
sustainably
reduce
level,
enhancing
DCs
activation
restoring
antitumor
immune
suppressed
by
(resulting
eightfold
increase
activation).
This
study
demonstrates
effective
synergistic
effects
between
photodynamic
therapy
immunotherapy
precisely
modulating
level.
Язык: Английский
Biomineralization-inspired functional biomaterials: From principles to practice
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 158624 - 158624
Опубликована: Дек. 1, 2024
Язык: Английский
Non-invasive fast assessment of hepatic injury through computed tomography imaging with renal-clearable Bi-DTPA dimeglumine
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Enhanced
computed
tomography
(CT)
imaging
with
iodinated
probes
is
widely
utilized
for
the
diagnosis
and
evaluation
of
various
liver
diseases.
However,
these
iodine-based
face
intractable
limitations
including
allergic
reactions
contraindications.
Herein,
we
propose
utilization
renal-clearable
iodine-free
bismuth
chelate
(Bi-DTPA
dimeglumine)
non-invasive
fast
assessment
hepatic
ischemia–reperfusion
injury
(HIRI)
via
CT
first
time.
Bi-DTPA
dimeglumine
offers
several
advantages
such
as
simple
synthesis,
no
purification
requirement,
a
yield
approaching
100%,
large-scale
production
capability
(laboratory
synthesis
>
100
g),
excellent
biocompatibility
superior
performance.
In
normal
rat
model,
administration
resulted
in
significant
63.79%
increase
value
within
very
short
time
period
(30
s).
Furthermore,
HIRI
enabled
rapid
differentiation
between
healthy
injured
areas
based
on
notable
disparity
values
early
15
min
post-reperfusion,
which
showed
strong
correlation
histopathological
analysis
results.
Additionally,
can
be
almost
eliminated
from
body
kidneys
24
h.
As
an
inherently
advantageous
alternative
to
probes,
exhibits
promising
prospects
application
disease
diagnosis.
Язык: Английский
The progress and prospect of calcium peroxide nanoparticles in cancer therapy
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
101, С. 106114 - 106114
Опубликована: Авг. 31, 2024
Язык: Английский
Three‐Pronged Induction of Tumor Calcification Synergistic Calcium Immunotherapy Enables Diagnosis and Cure of Cancer
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 6, 2024
Abstract
Tumor
calcification
is
considered
to
have
the
superiority
of
integrating
tumor
diagnosis
and
treatment,
it
also
has
been
found
be
a
predictor
favorable
prognosis.
However,
selecting
suitable
nanocarriers
therapeutic
drugs
maximize
efficiency
are
key
factors
for
improving
calcification‐medicated
theranostics.
This
study
performs
multi‐channel
nanoinitiator
(CalNI,
i.e.,
BP‐Cur‐Ca@P
KLAK
)
by
loading
curcumin
(Cur)
depositing
Ca
2+
on
black
phosphorus
(BP)
combined
carrying
mitochondria‐targeting
cytotoxic
peptide
boost
triple‐induced
calcification.
CalNI
preferentially
accumulates
inside
mitochondria
induces
multilevel
promotion
three
effects
(i)
degradation
BP
into
PO
4
3−
provides
source
required
calcification;
(ii)
burst
calcium
ions
can
directly
induce
cellular
overload;
(iii)
Cur
inhibit
efflux
thus
further
aggravate
intracellular
stress.
Moreover,
exhibited
enhanced
mitochondrial
synergistic
toxic
effects.
Notably,
potential
function
regulation
macrophage
polarization
could
completely
reverse
immunosuppressive
microenvironment,
activate
initiation
T
cell‐mediated
immune
response.
Therefore,
this
three‐pronged
showed
huge
promise
an
alternative
conventional
oncology
therapy,
which
presents
more
satisfactory
than
any
kind
single
induction
mode.
Язык: Английский